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Research Group



Prof. Dr. Martin Grininger

Cluster of Excellence Macromolecular Complexes
Goethe University Frankfurt, Riedberg Campus
BMLS Building, Room 2.636
Max-von-Laue-Str. 15
60438 Frankfurt am Main

Tel  +49 (0)69 798-42705
Lab +49 (0)69 798-42704


Martin Grininger

Lichtenberg Professor of the Volkswagen Foundation &
Junior Group Leader

Curriculum Vitae

2001-2002Diploma in Chemistry, Technical University Graz, Austria

2002-2006PhD, Ludwig Maximilians University Munich, Germany

2006-2011Group Leader of project group “Biological Chemistry”, Max-Planck-Institute of Biochemistry, Martinsried
near Munich, Germany

2010-2011Guest Professor, University Vienna, Faculty of
Chemistry, Wien, Austria

since 2012Lichtenberg-Professor, Cluster of Excellence
“Macromolecular Complexes”, Goethe University Frankfurt



Martin Grininger, Group Leader
Ines Gößner, Lab Manager
Jan Gajewski, PhD Student
Karthik Paithankar, Postdoctoral Fellow
Manuel Fischer, PhD Student
Mathias Enderle, PhD Student
Nina Socorro Cortina, Postdoctoral Fellow



Perspectives on the evolution, assembly and conformational dynamics of fatty acid synthase type I (FAS I) systems. Grininger, M; Curr Opin Struct Biol, 2014 Jan PubMed

Directed manipulation of a flavoprotein photocycle. Staudt, H; Hoesl, MG; Dreuw, A; Serdjukow, S; Oesterhelt, D; Budisa, N; Wachtveitl, J; Grininger, M; Angew Chem Int Ed Engl, 2013 Aug PubMed

Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex. Ciccarelli, L; Connell, SR; Enderle, M; Mills, DJ; Vonck, J; Grininger, M; Structure, 2013 Jul PubMed

The flavoprotein dodecin as a redox probe for electron transfer through DNA. Yu, Y; Heidel, B; Parapugna, TL; Wenderhold-Reeb, S; Song, B; Schönherr, H; Grininger, M; Nöll, G; Angew Chem Int Ed Engl, 2013 Apr PubMed

Ultrafast excited-state deactivation of flavins bound to dodecin. Staudt, H; Oesterhelt, D; Grininger, M; Wachtveitl, J; J Biol Chem, 2012 May PubMed

Mechanism of substrate shuttling by the acyl-carrier protein within the fatty acid mega-synthase. Anselmi, C; Grininger, M; Gipson, P; Faraldo-Gómez, JD; J Am Chem Soc, 2010 Sep PubMed

Structural and biochemical characterization of a halophilic archaeal alkaline phosphatase. Wende, A; Johansson, P; Vollrath, R; Dyall-Smith, M; Oesterhelt, D; Grininger, M; J Mol Biol, 2010 Jul PubMed

Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy. Gipson, P; Mills, DJ; Wouts, R; Grininger, M; Vonck, J; Kühlbrandt, W; Proc Natl Acad Sci U S A, 2010 May PubMed

Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase. Johansson, P; Mulinacci, B; Koestler, C; Vollrath, R; Oesterhelt, D; Grininger, M; Structure, 2009 Aug PubMed

Blue-light-triggered photorelease of active chemicals captured by the flavoprotein dodecin. Nöll, G; Trawöger, S; von Sanden-Flohe, M; Dick, B; Grininger, M; Chembiochem, 2009 Mar PubMed

Dodecin is the key player in flavin homeostasis of archaea. Grininger, M; Staudt, H; Johansson, P; Wachtveitl, J; Oesterhelt, D; J Biol Chem, 2009 May PubMed

Electrochemical switching of the flavoprotein dodecin at gold surfaces modified by flavin-DNA hybrid linkers. Grininger, M; Nöll, G; Trawöger, S; Sinner, EK; Oesterhelt, D; Biointerphases, 2008 Sep PubMed

Inhibition of the fungal fatty acid synthase type I multienzyme complex. Johansson, P; Wiltschi, B; Kumari, P; Kessler, B; Vonrhein, C; Vonck, J; Oesterhelt, D; Grininger, M; Proc Natl Acad Sci U S A, 2008 Sep PubMed

Dodecin sequesters FAD in closed conformation from the aqueous solution. Grininger, M; Seiler, F; Zeth, K; Oesterhelt, D; J Mol Biol, 2006 Dec PubMed

Dodecins: a family of lumichrome binding proteins. Grininger, M; Zeth, K; Oesterhelt, D; J Mol Biol, 2006 Mar PubMed

Parameters affecting the X-ray dose absorbed by macromolecular crystals. Murray, JW; Rudiño-Piñera, E; Owen, RL; Grininger, M; Ravelli, RB; Garman, EF; J Synchrotron Radiat, 2005 May PubMed

Expression, crystallization and crystallographic analysis of DegS, a stress sensor of the bacterial periplasm. Grininger, M; Ravelli, RB; Heider, U; Zeth, K; Acta Crystallogr D Biol Crystallogr, 2004 Aug PubMed

This colleague is a member of the following groups:
  • Protein Reaction Control