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Publications

Three-dimensional visualization of the molecular architecture of cell-cell junctions in situ by cryo-electron tomography of vitreous sections. Al-Amoudi, A; Frangakis, AS; Methods Mol Biol, 2013 PubMed

3D Ultrastructural organization of whole Chlamydomonas reinhardtii cells studied by nanoscale soft x-ray tomography. Hummel, E; Guttmann, P; Werner, S; Tarek, B; Schneider, G; Kunz, M; Frangakis, AS; Westermann, B; PLoS One, 2012 PubMed

Heritable yeast prions have a highly organized three-dimensional architecture with interfiber structures. Saibil, HR; Seybert, A; Habermann, A; Winkler, J; Eltsov, M; Perkovic, M; Castaño-Diez, D; Scheffer, MP; Haselmann, U; Chlanda, P; Lindquist, S; Tyedmers, J; Frangakis, AS; Proc Natl Acad Sci U S A, 2012 Sep PubMed

Room temperature L1₀ phase transformation in binary CoPt nanostructures prepared by focused-electron-beam-induced deposition. Porrati, F; Begun, E; Winhold, M; Schwalb, ChH; Sachser, R; Frangakis, AS; Huth, M; Nanotechnology, 2012 May PubMed

Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30-nm chromatin structure. Nishino, Y; Eltsov, M; Joti, Y; Ito, K; Takata, H; Takahashi, Y; Hihara, S; Frangakis, AS; Imamoto, N; Ishikawa, T; Maeshima, K; EMBO J, 2012 Apr PubMed

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Hergenreider, E; Heydt, S; Tréguer, K; Boettger, T; Horrevoets, AJ; Zeiher, AM; Scheffer, MP; Frangakis, AS; Yin, X; Mayr, M; Braun, T; Urbich, C; Boon, RA; Dimmeler, S; Nat Cell Biol, 2012 Mar PubMed

Nucleosomes stacked with aligned dyad axes are found in native compact chromatin in vitro. Scheffer, MP; Eltsov, M; Bednar, J; Frangakis, AS; J Struct Biol, 2012 May PubMed

Binary Pt-Si nanostructures prepared by focused electron-beam-induced deposition. Winhold, M; Schwalb, CH; Porrati, F; Sachser, R; Frangakis, AS; Kämpken, B; Terfort, A; Auner, N; Huth, M; ACS Nano, 2011 Dec PubMed

Evidence for short-range helical order in the 30-nm chromatin fibers of erythrocyte nuclei. Scheffer, MP; Eltsov, M; Frangakis, AS; Proc Natl Acad Sci U S A, 2011 Oct PubMed

The three-dimensional molecular structure of the desmosomal plaque. Al-Amoudi, A; Castaño-Diez, D; Devos, DP; Russell, RB; Johnson, GT; Frangakis, AS; Proc Natl Acad Sci U S A, 2011 Apr PubMed

Classification of electron sub-tomograms with neural networks and its application to template-matching. Yu, Z; Frangakis, AS; J Struct Biol, 2011 Jun PubMed

Structure of reconstituted bacterial membrane efflux pump by cryo-electron tomography. Trépout, S; Taveau, JC; Benabdelhak, H; Granier, T; Ducruix, A; Frangakis, AS; Lambert, O; Biochim Biophys Acta, 2010 Oct PubMed

Visualization of macromolecular structures. O'Donoghue, SI; Goodsell, DS; Frangakis, AS; Jossinet, F; Laskowski, RA; Nilges, M; Saibil, HR; Schafferhans, A; Wade, RC; Westhof, E; Olson, AJ; Nat Methods, 2010 Mar PubMed

Alignator: a GPU powered software package for robust fiducial-less alignment of cryo tilt-series. Castaño-Díez, D; Scheffer, M; Al-Amoudi, A; Frangakis, AS; J Struct Biol, 2010 Apr PubMed

Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing. Winkler, J; Seybert, A; König, L; Pruggnaller, S; Haselmann, U; Sourjik, V; Weiss, M; Frangakis, AS; Mogk, A; Bukau, B; EMBO J, 2010 Mar PubMed

Proteome organization in a genome-reduced bacterium. Kühner, S; van Noort, V; Betts, MJ; Leo-Macias, A; Batisse, C; Rode, M; Yamada, T; Maier, T; Bader, S; Beltran-Alvarez, P; Castaño-Diez, D; Chen, WH; Devos, D; Güell, M; Norambuena, T; Racke, I; Rybin, V; Schmidt, A; Yus, E; Aebersold, R; Herrmann, R; Böttcher, B; Frangakis, AS; Russell, RB; Serrano, L; Bork, P; Gavin, AC; Science, 2009 Nov PubMed

Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10. Janes, PW; Wimmer-Kleikamp, SH; Frangakis, AS; Treble, K; Griesshaber, B; Sabet, O; Grabenbauer, M; Ting, AY; Saftig, P; Bastiaens, PI; Lackmann, M; PLoS Biol, 2009 Oct PubMed

Analysis of cryo-electron microscopy images does not support the existence of 30-nm chromatin fibers in mitotic chromosomes in situ. Eltsov, M; Maclellan, KM; Maeshima, K; Frangakis, AS; Dubochet, J; Proc Natl Acad Sci U S A, 2008 Dec PubMed

Performance evaluation of image processing algorithms on the GPU. Castaño-Díez, D; Moser, D; Schoenegger, A; Pruggnaller, S; Frangakis, AS; J Struct Biol, 2008 Oct PubMed

A visualization and segmentation toolbox for electron microscopy. Pruggnaller, S; Mayr, M; Frangakis, AS; J Struct Biol, 2008 Oct PubMed

Structural studies on desmosomes. Al-Amoudi, A; Frangakis, AS; Biochem Soc Trans, 2008 Apr PubMed

Reprint of "Fiducial-less alignment of cryo-sections" [J. Struct. Biol. 159 (2007) 413-423]. Castaño-Díez, D; Al-Amoudi, A; Glynn, AM; Seybert, A; Frangakis, AS; J Struct Biol, 2008 Mar PubMed

The molecular architecture of cadherins in native epidermal desmosomes. Al-Amoudi, A; Díez, DC; Betts, MJ; Frangakis, AS; Nature, 2007 Dec PubMed

Classification of cryo-electron sub-tomograms using constrained correlation. Förster, F; Pruggnaller, S; Seybert, A; Frangakis, AS; J Struct Biol, 2008 Mar PubMed

Fiducial-less alignment of cryo-sections. Castaño-Díez, D; Al-Amoudi, A; Glynn, AM; Seybert, A; Frangakis, AS; J Struct Biol, 2007 Sep PubMed

Plastic-embedded protein crystals. Ravelli, RB; Haselmann-Weiss, U; McGeehan, JE; McCarthy, AA; Marquez, JA; Antony, C; Frangakis, AS; Stranzl, G; J Synchrotron Radiat, 2007 Jan PubMed

Visualization of cell microtubules in their native state. Bouchet-Marquis, C; Zuber, B; Glynn, AM; Eltsov, M; Grabenbauer, M; Goldie, KN; Thomas, D; Frangakis, AS; Dubochet, J; Chrétien, D; Biol Cell, 2007 Jan PubMed

Implementation and performance evaluation of reconstruction algorithms on graphics processors. Castaño Díez, D; Mueller, H; Frangakis, AS; J Struct Biol, 2007 Jan PubMed

Multiple large filament bundles observed in Caulobacter crescentus by electron cryotomography. Briegel, A; Dias, DP; Li, Z; Jensen, RB; Frangakis, AS; Jensen, GJ; Mol Microbiol, 2006 Oct PubMed

Structural analysis of Mycoplasma pneumoniae by cryo-electron tomography. Seybert, A; Herrmann, R; Frangakis, AS; J Struct Biol, 2006 Nov PubMed

Tilt-series and electron microscope alignment for the correction of the non-perpendicularity of beam and tilt-axis. Díez, DC; Seybert, A; Frangakis, AS; J Struct Biol, 2006 May PubMed

Cryo-electron tomography reveals the cytoskeletal structure of Spiroplasma melliferum. Kürner, J; Frangakis, AS; Baumeister, W; Science, 2005 Jan PubMed

Computational exploration of structural information from cryo-electron tomograms. Frangakis, AS; Förster, F; Curr Opin Struct Biol, 2004 Jun PubMed

Macromolecular architecture in eukaryotic cells visualized by cryoelectron tomography. Medalia, O; Weber, I; Frangakis, AS; Nicastro, D; Gerisch, G; Baumeister, W; Science, 2002 Nov PubMed

Identification of macromolecular complexes in cryoelectron tomograms of phantom cells. Frangakis, AS; Böhm, J; Förster, F; Nickell, S; Nicastro, D; Typke, D; Hegerl, R; Baumeister, W; Proc Natl Acad Sci U S A, 2002 Oct PubMed

Segmentation of two- and three-dimensional data from electron microscopy using eigenvector analysis. Frangakis, AS; Hegerl, R; J Struct Biol, PubMed

Noise reduction in electron tomographic reconstructions using nonlinear anisotropic diffusion. Frangakis, AS; Hegerl, R; J Struct Biol, 2001 Sep PubMed

FhuA-mediated phage genome transfer into liposomes: a cryo-electron tomography study. Böhm, J; Lambert, O; Frangakis, AS; Letellier, L; Baumeister, W; Rigaud, JL; Curr Biol, 2001 Aug PubMed

Wavelet transform filtering and nonlinear anisotropic diffusion assessed for signal reconstruction performance on multidimensional biomedical data. Frangakis, AS; Stoschek, A; Hegerl, R; IEEE Trans Biomed Eng, 2001 Feb PubMed

Toward detecting and identifying macromolecules in a cellular context: template matching applied to electron tomograms. Bohm, J; Frangakis, AS; Hegerl, R; Nickell, S; Typke, D; Baumeister, W; Proc Natl Acad Sci U S A, 2000 Dec PubMed

Cryo-electron tomography of neurospora mitochondria. Nicastro, D; Frangakis, AS; Typke, D; Baumeister, W; J Struct Biol, 2000 Feb PubMed