Research Groups

 

Publications of Harald Schwalbe (Results: 382)

 

Biophysical Investigation of RNA•DNA:DNA triple helix and RNA:DNA heteroduplex formation by the lncRNAs MEG3 and Fendrr.
Chembiochem : a European journal of chemical biology
Krause NM, Kaur Bains J, Blechar J, Richter C, Bessi I, Grote P, Leisegang M, Brandes RP, Schwalbe H PubMed
Mar 2024 Volume: Issue: Pages: e202400049

Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocyclization.
Chemical communications (Cambridge, England)
Lala B, Chaudhuri R, Prasanth T, Burkhart I, Schwalbe H, Dash J PubMed
Mar 2024 Volume: Issue: Pages:

Shine-Dalgarno Accessibility Governs Ribosome Binding to the Adenine Riboswitch.
ACS chemical biology
Blechar J, de Jesus V, Fürtig B, Hengesbach M, Schwalbe H PubMed
Mar 2024 Volume: 19 Issue: 3 Pages: 607-618

NMR H,F-based screening of the four stem-looped structure 5_SL1-SL4 located in the 5'-untranslated region of SARS-CoV 2 RNA.
RSC medicinal chemistry
Hymon D, Martins J, Richter C, Sreeramulu S, Wacker A, Ferner J, Patwardhan NN, Hargrove AE, Schwalbe H PubMed
Jan 2024 Volume: 15 Issue: 1 Pages: 165-177

Targeting the Main Protease (M, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies.
ACS chemical biology
Altincekic N, Jores N, Löhr F, Richter C, Ehrhardt C, Blommers MJJ, Berg H, Öztürk S, Gande SL, Linhard V, Orts J, Abi Saad MJ, Bütikofer M, Kaderli J, Karlsson BG, Brath U, Hedenström M, Gröbner G, Sauer UH, Perrakis A, Langer J, Banci L, Cantini F, Fragai M, Grifagni D, Barthel T, Wollenhaupt J, Weiss MS, Robertson A, Bax A, Sreeramulu S, Schwalbe H PubMed
Feb 2024 Volume: 19 Issue: 2 Pages: 563-574

Characterization of the zinc finger μ-protein HVO_0758 from : biological roles, zinc binding, and NMR solution structure.
Frontiers in microbiology
Üresin D, Pyper DJ, Borst A, Hadjeras L, Gelhausen R, Backofen R, Sharma C, Schwalbe H, Soppa J PubMed
2023 Volume: 14 Issue: Pages: 1280972

RNA G-quadruplex folding is a multi-pathway process driven by conformational entropy.
Nucleic acids research
Ugrina M, Burkhart I, Müller D, Schwalbe H, Schwierz N PubMed
Jan 2024 Volume: 52 Issue: 1 Pages: 87-100

PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia.
Leukemia
Alshamleh I, Kurrle N, Makowka P, Bhayadia R, Kumar R, Süsser S, Seibert M, Ludig D, Wolf S, Koschade SE, Stoschek K, Kreitz J, Fuhrmann DC, Toenges R, Notaro M, Comoglio F, Schuringa JJ, Berg T, Brüne B, Krause DS, Klusmann JH, Oellerich T, Schnütgen F, Schwalbe H, Serve H PubMed
Dec 2023 Volume: 37 Issue: 12 Pages: 2367-2382

High-resolution structure of stem-loop 4 from the 5'-UTR of SARS-CoV-2 solved by solution state NMR.
Nucleic acids research
Vögele J, Hymon D, Martins J, Ferner J, Jonker HRA, Hargrove AE, Weigand JE, Wacker A, Schwalbe H, Wöhnert J, Duchardt-Ferner E PubMed
Nov 2023 Volume: 51 Issue: 20 Pages: 11318-11331

Targeting EPHA2 with Kinase Inhibitors in Colorectal Cancer.
ChemMedChem
Tröster A, Jores N, Mineev KS, Sreeramulu S, DiPrima M, Tosato G, Schwalbe H PubMed
Dec 2023 Volume: 18 Issue: 23 Pages: e202300420

Integrated NMR/Molecular Dynamics Determination of the Ensemble Conformation of a Thermodynamically Stable CUUG RNA Tetraloop.
Journal of the American Chemical Society
Oxenfarth A, Kümmerer F, Bottaro S, Schnieders R, Pinter G, Jonker HRA, Fürtig B, Richter C, Blackledge M, Lindorff-Larsen K, Schwalbe H PubMed
Aug 2023 Volume: 145 Issue: 30 Pages: 16557-16572

Cell-free transcription-translation system: a dual read-out assay to characterize riboswitch function.
Nucleic acids research
Bains JK, Qureshi NS, Ceylan B, Wacker A, Schwalbe H PubMed
Aug 2023 Volume: 51 Issue: 15 Pages: e82

Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA triplex element.
Nucleic acids research
Ali T, Rogala S, Krause NM, Bains JK, Melissari MT, Währisch S, Schwalbe H, Herrmann BG, Grote P PubMed
Jul 2023 Volume: 51 Issue: 12 Pages: 6227-6237

Chemiluminescence Biosensor for the Determination of Cardiac Troponin I (cTnI).
Biosensors
Tannenberg R, Paul M, Röder B, Gande SL, Sreeramulu S, Saxena K, Richter C, Schwalbe H, Swart C, Weller MG PubMed
Apr 2023 Volume: 13 Issue: 4 Pages:

NMR resonance assignment of a fibroblast growth factor 8 splicing isoform b.
Biomolecular NMR assignments
Hargittay B, Mineev KS, Richter C, Sreeramulu S, Jonker HRA, Saxena K, Schwalbe H PubMed
Jun 2023 Volume: 17 Issue: 1 Pages: 135-142

Identifying and Overcoming Artifacts in H-Based Saturation Transfer NOE NMR Experiments.
Journal of the American Chemical Society
Grün JT, Kim J, Jayanthi S, Lupulescu A, Kupče ER, Schwalbe H, Frydman L PubMed
Mar 2023 Volume: 145 Issue: 11 Pages: 6289-6298

Crystal structure of the CoV-Y domain of SARS-CoV-2 nonstructural protein 3.
Scientific reports
Li Y, Pustovalova Y, Shi W, Gorbatyuk O, Sreeramulu S, Schwalbe H, Hoch JC, Hao B PubMed
Feb 2023 Volume: 13 Issue: 1 Pages: 2890

Optimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor.
Chemistry (Weinheim an der Bergstrasse, Germany)
Tröster A, DiPrima M, Jores N, Kudlinzki D, Sreeramulu S, Gande SL, Linhard V, Ludig D, Schug A, Saxena K, Reinecke M, Heinzlmeir S, Leisegang MS, Wollenhaupt J, Lennartz F, Weiss MS, Kuster B, Tosato G, Schwalbe H PubMed
Apr 2023 Volume: 29 Issue: 23 Pages: e202203967

The COVID19-NMR Consortium: A Public Report on the Impact of this New Global Collaboration.
Angewandte Chemie (International ed. in English)
Duchardt-Ferner E, Ferner J, Fürtig B, Hengesbach M, Richter C, Schlundt A, Sreeramulu S, Wacker A, Weigand JE, Wirmer-Bartoschek J, Schwalbe H PubMed
Mar 2023 Volume: 62 Issue: 14 Pages: e202217171

Modulation of Aβ42 Aggregation Kinetics and Pathway by Low-Molecular-Weight Inhibitors.
Chembiochem : a European journal of chemical biology
Hutchison MT, Bellomo G, Cherepanov A, Stirnal E, Fürtig B, Richter C, Linhard V, Gurewitsch E, Lelli M, Morgner N, Schrader T, Schwalbe H PubMed
Apr 2023 Volume: 24 Issue: 7 Pages: e202200760

Site-Specific Labeling of RNAs with Modified and F-Labeled Nucleotides by Chemo-Enzymatic Synthesis.
Chemistry (Weinheim an der Bergstrasse, Germany)
Sudakov A, Knezic B, Hengesbach M, Fürtig B, Stirnal E, Schwalbe H PubMed
May 2023 Volume: 29 Issue: 25 Pages: e202203368

The MECP2-TRD domain interacts with the DNMT3A-ADD domain at the H3-tail binding site.
Protein science : a publication of the Protein Society
Kunert S, Linhard V, Weirich S, Choudalakis M, Osswald F, Krämer L, Köhler AR, Bröhm A, Wollenhaupt J, Schwalbe H, Jeltsch A PubMed
Jan 2023 Volume: 32 Issue: 1 Pages: e4542

HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex.
Nature communications
Leisegang MS, Bains JK, Seredinski S, Oo JA, Krause NM, Kuo CC, Günther S, Sentürk Cetin N, Warwick T, Cao C, Boos F, Izquierdo Ponce J, Haydar S, Bednarz R, Valasarajan C, Fuhrmann DC, Preussner J, Looso M, Pullamsetti SS, Schulz MH, Jonker HRA, Richter C, Rezende F, Gilsbach R, Pflüger-Müller B, Wittig I, Grummt I, Ribarska T, Costa IG, Schwalbe H, Brandes RP PubMed
Nov 2022 Volume: 13 Issue: 1 Pages: 6563

Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators.
ACS chemical biology
Heering J, Jores N, Kilu W, Schallmayer E, Peelen E, Muehler A, Kohlhof H, Vitt D, Linhard V, Gande SL, Chaikuad A, Sreeramulu S, Schwalbe H, Merk D PubMed
Nov 2022 Volume: 17 Issue: 11 Pages: 3159-3168

A universal model of RNA.DNA:DNA triplex formation accurately predicts genome-wide RNA-DNA interactions.
Briefings in bioinformatics
Warwick T, Seredinski S, Krause NM, Bains JK, Althaus L, Oo JA, Bonetti A, Dueck A, Engelhardt S, Schwalbe H, Leisegang MS, Schulz MH, Brandes RP PubMed
Nov 2022 Volume: 23 Issue: 6 Pages:

Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug Development.
Angewandte Chemie (International ed. in English)
Berg H, Wirtz Martin MA, Altincekic N, Alshamleh I, Kaur Bains J, Blechar J, Ceylan B, de Jesus V, Dhamotharan K, Fuks C, Gande SL, Hargittay B, Hohmann KF, Hutchison MT, Marianne Korn S, Krishnathas R, Kutz F, Linhard V, Matzel T, Meiser N, Niesteruk A, Pyper DJ, Schulte L, Trucks S, Azzaoui K, Blommers MJJ, Gadiya Y, Karki R, Zaliani A, Gribbon P, da Silva Almeida M, Dinis Anobom C, Bula AL, Bütikofer M, Putinhon Caruso Í, Caterina Felli I, Da Poian AT, Cardoso de Amorim G, Fourkiotis NK, Ga... PubMed
Nov 2022 Volume: 61 Issue: 46 Pages: e202205858

Dietary methionine starvation impairs acute myeloid leukemia progression.
Blood
Cunningham A, Erdem A, Alshamleh I, Geugien M, Pruis M, Pereira-Martins DA, van den Heuvel FAJ, Wierenga ATJ, Ten Berge H, Dennebos R, van den Boom V, Hogeling SM, Weinhäuser I, Knops R, de Blaauw P, Heiner-Fokkema MR, Woolthuis C, Günther UL, Rego EM, Martens JHA, Jansen JH, Schwalbe H, Huls G, Schuringa JJ PubMed
Nov 2022 Volume: 140 Issue: 19 Pages: 2037-2052

Synthesis of a Peptidoyl RNA Hairpin via a Combination of Solid-Phase and Template-Directed Chain Assembly.
Chembiochem : a European journal of chemical biology
Bremer J, Richter C, Schwalbe H, Richert C PubMed
Sep 2022 Volume: 23 Issue: 18 Pages: e202200352

Binding Adaptation of GS-441524 Diversifies Macro Domains and Downregulates SARS-CoV-2 de-MARylation Capacity.
Journal of molecular biology
Tsika AC, Gallo A, Fourkiotis NK, Argyriou AI, Sreeramulu S, Löhr F, Rogov VV, Richter C, Linhard V, Gande SL, Altincekic N, Krishnathas R, Elamri I, Schwalbe H, Wollenhaupt J, Weiss MS, Spyroulias GA PubMed
Aug 2022 Volume: 434 Issue: 16 Pages: 167720

The cotranscriptional folding landscape for two cyclic di-nucleotide-sensing riboswitches with highly homologous aptamer domains acting either as ON- or OFF-switches.
Nucleic acids research
Landgraf T, Völklein AE, Fürtig B, Schwalbe H PubMed
Jul 2022 Volume: 50 Issue: 12 Pages: 6639-6655

Randomizing of Oligopeptide Conformations by Nearest Neighbor Interactions between Amino Acid Residues.
Biomolecules
Schweitzer-Stenner R, Milorey B, Schwalbe H PubMed
May 2022 Volume: 12 Issue: 5 Pages:

Corrigendum: Folding dynamics of polymorphic G-quadruplex structures.
Biopolymers
Grün JT, Schwalbe H PubMed
May 2022 Volume: 113 Issue: 5 Pages: e23517

Oxidation of the Mycobacterium tuberculosis key virulence factor protein tyrosine phosphatase A (MptpA) reduces its phosphatase activity.
FEBS letters
Niesteruk A, Sreeramulu S, Jonker HRA, Richter C, Schwalbe H PubMed
Jun 2022 Volume: 596 Issue: 12 Pages: 1503-1515

H, C and N chemical shift assignment of the stem-loops 5b + c from the 5'-UTR of SARS-CoV-2.
Biomolecular NMR assignments
Mertinkus KR, Grün JT, Altincekic N, Bains JK, Ceylan B, Ferner JP, Frydman L, Fürtig B, Hengesbach M, Hohmann KF, Hymon D, Kim J, Knezic B, Novakovic M, Oxenfarth A, Peter SA, Qureshi NS, Richter C, Scherf T, Schlundt A, Schnieders R, Schwalbe H, Stirnal E, Sudakov A, Vögele J, Wacker A, Weigand JE, Wirmer-Bartoschek J, Martin MAW, Wöhnert J PubMed
Apr 2022 Volume: 16 Issue: 1 Pages: 17-25

Structural analysis of temperature-dependent alternative splicing of HsfA2 pre-mRNA from tomato plants.
RNA biology
Broft P, Rosenkranz R, Schleiff E, Hengesbach M, Schwalbe H PubMed
2022 Volume: 19 Issue: 1 Pages: 266-278

Mapping the Conformational Landscape of the Neutral Network of RNA Sequences That Connect Two Functional Distinctly Different Ribozymes.
Chembiochem : a European journal of chemical biology
Knezic B, Keyhani-Goldau S, Schwalbe H PubMed
Apr 2022 Volume: 23 Issue: 7 Pages: e202200022

The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments Among Labile and Non-Labile Hs of SARS-CoV-2-derived RNAs.
Chemphyschem : a European journal of chemical physics and physical chemistry
Kim J, Novakovic M, Jayanthi S, Lupulescu A, Kupče Ē, Grün JT, Mertinkus K, Oxenfarth A, Schwalbe H, Frydman L PubMed
Feb 2022 Volume: 23 Issue: 4 Pages: e202100704

The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Xanthines.
ACS pharmacology & translational science
Faudone G, Kilu W, Ni X, Chaikuad A, Sreeramulu S, Heitel P, Schwalbe H, Knapp S, Schubert-Zsilavecz M, Heering J, Merk D PubMed
Dec 2021 Volume: 4 Issue: 6 Pages: 1794-1807

Short-chain aurachin D derivatives are selective inhibitors of E. coli cytochrome bd-I and bd-II oxidases.
Scientific reports
Radloff M, Elamri I, Grund TN, Witte LF, Hohmann KF, Nakagaki S, Goojani HG, Nasiri H, Hideto Miyoshi , Bald D, Xie H, Sakamoto J, Schwalbe H, Safarian S PubMed
Dec 2021 Volume: 11 Issue: 1 Pages: 23852

Metabolic Rewiring Is Essential for AML Cell Survival to Overcome Autophagy Inhibition by Loss of ATG3.
Cancers
Baker F, Polat IH, Abou-El-Ardat K, Alshamleh I, Thoelken M, Hymon D, Gubas A, Koschade SE, Vischedyk JB, Kaulich M, Schwalbe H, Shaid S, Brandts CH PubMed
Dec 2021 Volume: 13 Issue: 23 Pages:

Mechanistic and structural diversity between cytochrome isoforms of .
Proceedings of the National Academy of Sciences of the United States of America
Grund TN, Radloff M, Wu D, Goojani HG, Witte LF, Jösting W, Buschmann S, Müller H, Elamri I, Welsch S, Schwalbe H, Michel H, Bald D, Safarian S PubMed
Dec 2021 Volume: 118 Issue: 50 Pages:

iNEXT-Discovery and Instruct-ERIC: Integrating High-End Services for Translational Research in Structural Biology.
Journal of visualized experiments : JoVE
Wienk H, Banci L, Daenke S, Pereiro E, Schwalbe H, Stuart DI, Weiss MS, Perrakis A PubMed
Nov 2021 Volume: Issue: 177 Pages:

Characterization of Structure and Dynamics of the Guanidine-II Riboswitch from Escherichia coli by NMR Spectroscopy and Small-Angle X-ray Scattering (SAXS).
Chembiochem : a European journal of chemical biology
Schamber T, Binas O, Schlundt A, Wacker A, Schwalbe H PubMed
Feb 2022 Volume: 23 Issue: 3 Pages: e202100564

Solid-Phase-Supported Chemoenzymatic Synthesis of a Light-Activatable tRNA Derivative.
Angewandte Chemie (International ed. in English)
Blümler A, Schwalbe H, Heckel A PubMed
Jan 2022 Volume: 61 Issue: 1 Pages: e202111613

Folding dynamics of polymorphic G-quadruplex structures.
Biopolymers
Grün JT, Schwalbe H PubMed
Jan 2022 Volume: 113 Issue: 1 Pages: e23477

Repeating Aspartic Acid Residues Prefer Turn-like Conformations in the Unfolded State: Implications for Early Protein Folding.
The journal of physical chemistry. B
Milorey B, Schwalbe H, O'Neill N, Schweitzer-Stenner R PubMed
Oct 2021 Volume: 125 Issue: 41 Pages: 11392-11407

Oxidative Folding of Proteins: The "Smoking Gun" of Glutathione.
International journal of molecular sciences
Bocedi A, Cattani G, Gambardella G, Schulte L, Schwalbe H, Ricci G PubMed
Sep 2021 Volume: 22 Issue: 18 Pages:

H, C and N assignment of stem-loop SL1 from the 5'-UTR of SARS-CoV-2.
Biomolecular NMR assignments
Richter C, Hohmann KF, Toews S, Mathieu D, Altincekic N, Bains JK, Binas O, Ceylan B, Duchardt-Ferner E, Ferner J, Fürtig B, Grün JT, Hengesbach M, Hymon D, Jonker HRA, Knezic B, Korn SM, Landgraf T, Löhr F, Peter SA, Pyper DJ, Qureshi NS, Schlundt A, Schnieders R, Stirnal E, Sudakov A, Vögele J, Weigand JE, Wirmer-Bartoschek J, Witt K, Wöhnert J, Schwalbe H, Wacker A PubMed
Oct 2021 Volume: 15 Issue: 2 Pages: 467-474

Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation.
Nature communications
de Jesus V, Qureshi NS, Warhaut S, Bains JK, Dietz MS, Heilemann M, Schwalbe H, Fürtig B PubMed
Aug 2021 Volume: 12 Issue: 1 Pages: 4723

Wavelength-Selective Uncaging of Two Different Photoresponsive Groups on One Effector Molecule for Light-Controlled Activation and Deactivation.
Journal of the American Chemical Society
Elamri I, Abdellaoui C, Bains JK, Hohmann KF, Gande SL, Stirnal E, Wachtveitl J, Schwalbe H PubMed
Jul 2021 Volume: 143 Issue: 28 Pages: 10596-10603

Magnetization Transfer to Enhance NOE Cross-Peaks among Labile Protons: Applications to Imino-Imino Sequential Walks in SARS-CoV-2-Derived RNAs.
Angewandte Chemie (Weinheim an der Bergstrasse, Germany)
Novakovic M, Kupče Ē, Scherf T, Oxenfarth A, Schnieders R, Grün JT, Wirmer-Bartoschek J, Richter C, Schwalbe H, Frydman L PubMed
May 2021 Volume: 133 Issue: 21 Pages: 11991-11998

NMR structure of the Vibrio vulnificus ribosomal protein S1 domains D3 and D4 provides insights into molecular recognition of single-stranded RNAs.
Nucleic acids research
Qureshi NS, Matzel T, Cetiner EC, Schnieders R, Jonker HRA, Schwalbe H, Fürtig B PubMed
Jul 2021 Volume: 49 Issue: 13 Pages: 7753-7764

Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS-CoV-2 Genome.
Angewandte Chemie (International ed. in English)
Sreeramulu S, Richter C, Berg H, Wirtz Martin MA, Ceylan B, Matzel T, Adam J, Altincekic N, Azzaoui K, Bains JK, Blommers MJJ, Ferner J, Fürtig B, Göbel M, Grün JT, Hengesbach M, Hohmann KF, Hymon D, Knezic B, Martins JN, Mertinkus KR, Niesteruk A, Peter SA, Pyper DJ, Qureshi NS, Scheffer U, Schlundt A, Schnieders R, Stirnal E, Sudakov A, Tröster A, Vögele J, Wacker A, Weigand JE, Wirmer-Bartoschek J, Wöhnert J, Schwalbe H PubMed
Aug 2021 Volume: 60 Issue: 35 Pages: 19191-19200

Correction to 'Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy'.
Nucleic acids research
Wacker A, Weigand JE, Akabayov SR, Altincekic N, Bains JK, Banijamali E, Binas O, Castillo-Martinez J, Cetiner E, Ceylan B, Chiu LY, Davila-Calderon J, Dhamotharan K, Duchardt-Ferner E, Ferner J, Frydman L, Fürtig B, Gallego J, Grün JT, Hacker C, Haddad C, Hähnke M, Hengesbach M, Hiller F, Hohmann KF, Hymon D, de Jesus V, Jonker H, Keller H, Knezic B, Landgraf T, Löhr F, Luo L, Mertinkus KR, Muhs C, Novakovic M, Oxenfarth A, Palomino-Schätzlein M, Petzold K, Peter SA, Pyper DJ, Qureshi NS, ... PubMed
Jul 2021 Volume: 49 Issue: 12 Pages: 7204-7205

Insights from Binding on Quadruplex Selective Carbazole Ligands.
Chemistry (Weinheim an der Bergstrasse, Germany)
Müller D, Saha P, Panda D, Dash J, Schwalbe H PubMed
Sep 2021 Volume: 27 Issue: 50 Pages: 12726-12736

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery.
Journal of visualized experiments : JoVE
Ahmad MUD, Fish A, Molenaar J, Sreeramulu S, Richter C, Altincekic N, Schwalbe H, Wienk H, Perrakis A PubMed
May 2021 Volume: Issue: 171 Pages:

Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications.
Frontiers in molecular biosciences
Altincekic N, Korn SM, Qureshi NS, Dujardin M, Ninot-Pedrosa M, Abele R, Abi Saad MJ, Alfano C, Almeida FCL, Alshamleh I, de Amorim GC, Anderson TK, Anobom CD, Anorma C, Bains JK, Bax A, Blackledge M, Blechar J, Böckmann A, Brigandat L, Bula A, Bütikofer M, Camacho-Zarco AR, Carlomagno T, Caruso IP, Ceylan B, Chaikuad A, Chu F, Cole L, Crosby MG, de Jesus V, Dhamotharan K, Felli IC, Ferner J, Fleischmann Y, Fogeron ML, Fourkiotis NK, Fuks C, Fürtig B, Gallo A, Gande SL, Gerez JA, Ghosh D, Gom... PubMed
2021 Volume: 8 Issue: Pages: 653148

Real-time nuclear magnetic resonance spectroscopy in the study of biomolecular kinetics and dynamics.
Magnetic resonance (Gottingen, Germany)
Pintér G, Hohmann KF, Grün JT, Wirmer-Bartoschek J, Glaubitz C, Fürtig B, Schwalbe H PubMed
2021 Volume: 2 Issue: 1 Pages: 291-320

H, C, N and P chemical shift assignment for stem-loop 4 from the 5'-UTR of SARS-CoV-2.
Biomolecular NMR assignments
Vögele J, Ferner JP, Altincekic N, Bains JK, Ceylan B, Fürtig B, Grün JT, Hengesbach M, Hohmann KF, Hymon D, Knezic B, Löhr F, Peter SA, Pyper D, Qureshi NS, Richter C, Schlundt A, Schwalbe H, Stirnal E, Sudakov A, Wacker A, Weigand JE, Wirmer-Bartoschek J, Wöhnert J, Duchardt-Ferner E PubMed
Oct 2021 Volume: 15 Issue: 2 Pages: 335-340

Unraveling the Kinetics of Spare-Tire DNA G-Quadruplex Folding.
Journal of the American Chemical Society
Grün JT, Blümler A, Burkhart I, Wirmer-Bartoschek J, Heckel A, Schwalbe H PubMed
Apr 2021 Volume: 143 Issue: 16 Pages: 6185-6193

3D Heteronuclear Magnetization Transfers for the Establishment of Secondary Structures in SARS-CoV-2-Derived RNAs.
Journal of the American Chemical Society
Kim J, Novakovic M, Jayanthi S, Lupulescu A, Kupce E, Grün JT, Mertinkus K, Oxenfarth A, Richter C, Schnieders R, Wirmer-Bartoschek J, Schwalbe H, Frydman L PubMed
Apr 2021 Volume: 143 Issue: 13 Pages: 4942-4948

H, C, and N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein).
Biomolecular NMR assignments
Wang Y, Kirkpatrick J, Zur Lage S, Korn SM, Neißner K, Schwalbe H, Schlundt A, Carlomagno T PubMed
Oct 2021 Volume: 15 Issue: 2 Pages: 287-295

Backbone chemical shift spectral assignments of SARS coronavirus-2 non-structural protein nsp9.
Biomolecular NMR assignments
F Dudás E, Puglisi R, Korn SM, Alfano C, Bellone ML, Piaz FD, Kelly G, Monaca E, Schlundt A, Schwalbe H, Pastore A PubMed
Oct 2021 Volume: 15 Issue: 2 Pages: 235-241

Magnetization Transfer to Enhance NOE Cross-Peaks among Labile Protons: Applications to Imino-Imino Sequential Walks in SARS-CoV-2-Derived RNAs.
Angewandte Chemie (International ed. in English)
Novakovic M, Kupče Ē, Scherf T, Oxenfarth A, Schnieders R, Grün JT, Wirmer-Bartoschek J, Richter C, Schwalbe H, Frydman L PubMed
May 2021 Volume: 60 Issue: 21 Pages: 11884-11891

High complexity of Glutamine synthetase regulation in Methanosarcina mazei: Small protein 26 interacts and enhances glutamine synthetase activity.
The FEBS journal
Gutt M, Jordan B, Weidenbach K, Gudzuhn M, Kiessling C, Cassidy L, Helbig A, Tholey A, Pyper DJ, Kubatova N, Schwalbe H, Schmitz RA PubMed
Sep 2021 Volume: 288 Issue: 18 Pages: 5350-5373

The Folding Landscapes of Human Telomeric RNA and DNA G-Quadruplexes are Markedly Different.
Angewandte Chemie (International ed. in English)
Müller D, Bessi I, Richter C, Schwalbe H PubMed
May 2021 Volume: 60 Issue: 19 Pages: 10895-10901

Synthesis and in Vitro Evaluation of Novel 5-Nitroindole Derivatives as c-Myc G-Quadruplex Binders with Anticancer Activity.
ChemMedChem
Nimbarte VD, Wirmer-Bartoschek J, Gande SL, Alshamleh I, Seibert M, Nasiri HR, Schnütgen F, Serve H, Schwalbe H PubMed
May 2021 Volume: 16 Issue: 10 Pages: 1667-1679

H, C and N chemical shift assignment of the stem-loop 5a from the 5'-UTR of SARS-CoV-2.
Biomolecular NMR assignments
Schnieders R, Peter SA, Banijamali E, Riad M, Altincekic N, Bains JK, Ceylan B, Fürtig B, Grün JT, Hengesbach M, Hohmann KF, Hymon D, Knezic B, Oxenfarth A, Petzold K, Qureshi NS, Richter C, Schlagnitweit J, Schlundt A, Schwalbe H, Stirnal E, Sudakov A, Vögele J, Wacker A, Weigand JE, Wirmer-Bartoschek J, Wöhnert J PubMed
Apr 2021 Volume: 15 Issue: 1 Pages: 203-211

H, C and N backbone chemical shift assignments of SARS-CoV-2 nsp3a.
Biomolecular NMR assignments
Salvi N, Bessa LM, Guseva S, Camacho-Zarco A, Maurin D, Perez LM, Malki A, Hengesbach M, Korn SM, Schlundt A, Schwalbe H, Blackledge M PubMed
Apr 2021 Volume: 15 Issue: 1 Pages: 173-176

Parallel reaction pathways accelerate folding of a guanine quadruplex.
Nucleic acids research
Harkness RW, Hennecker C, Grün JT, Blümler A, Heckel A, Schwalbe H, Mittermaier AK PubMed
Feb 2021 Volume: 49 Issue: 3 Pages: 1247-1262

Short peptides as predictors for the structure of polyarginine sequences in disordered proteins.
Biophysical journal
Milorey B, Schweitzer-Stenner R, Andrews B, Schwalbe H, Urbanc B PubMed
Feb 2021 Volume: 120 Issue: 4 Pages: 662-676

H,C and N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: "The SUD-M and SUD-C domains".
Biomolecular NMR assignments
Gallo A, Tsika AC, Fourkiotis NK, Cantini F, Banci L, Sreeramulu S, Schwalbe H, Spyroulias GA PubMed
Apr 2021 Volume: 15 Issue: 1 Pages: 165-171

Functional implications of MIR domains in protein -mannosylation.
eLife
Chiapparino A, Grbavac A, Jonker HR, Hackmann Y, Mortensen S, Zatorska E, Schott A, Stier G, Saxena K, Wild K, Schwalbe H, Strahl S, Sinning I PubMed
Dec 2020 Volume: 9 Issue: Pages:

Solution structure of the voltage-gated Tim23 channel in complex with a mitochondrial presequence peptide.
Cell research
Zhou S, Ruan M, Li Y, Yang J, Bai S, Richter C, Schwalbe H, Xie C, Shen B, Wang J PubMed
Jul 2021 Volume: 31 Issue: 7 Pages: 821-824

H, C, and N backbone chemical shift assignments of the C-terminal dimerization domain of SARS-CoV-2 nucleocapsid protein.
Biomolecular NMR assignments
Korn SM, Lambertz R, Fürtig B, Hengesbach M, Löhr F, Richter C, Schwalbe H, Weigand JE, Wöhnert J, Schlundt A PubMed
Apr 2021 Volume: 15 Issue: 1 Pages: 129-135

Metabolic Plasticity Is an Essential Requirement of Acquired Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia.
Cancers
Mostazo MGC, Kurrle N, Casado M, Fuhrmann D, Alshamleh I, Häupl B, Martín-Sanz P, Brüne B, Serve H, Schwalbe H, Schnütgen F, Marin S, Cascante M PubMed
Nov 2020 Volume: 12 Issue: 11 Pages:

H,C and N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: "the N-terminal domain-SUD-N".
Biomolecular NMR assignments
Gallo A, Tsika AC, Fourkiotis NK, Cantini F, Banci L, Sreeramulu S, Schwalbe H, Spyroulias GA PubMed
Apr 2021 Volume: 15 Issue: 1 Pages: 85-89

Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy.
Nucleic acids research
Wacker A, Weigand JE, Akabayov SR, Altincekic N, Bains JK, Banijamali E, Binas O, Castillo-Martinez J, Cetiner E, Ceylan B, Chiu LY, Davila-Calderon J, Dhamotharan K, Duchardt-Ferner E, Ferner J, Frydman L, Fürtig B, Gallego J, Grün JT, Hacker C, Haddad C, Hähnke M, Hengesbach M, Hiller F, Hohmann KF, Hymon D, de Jesus V, Jonker H, Keller H, Knezic B, Landgraf T, Löhr F, Luo L, Mertinkus KR, Muhs C, Novakovic M, Oxenfarth A, Palomino-Schätzlein M, Petzold K, Peter SA, Pyper DJ, Qureshi NS, ... PubMed
Dec 2020 Volume: 48 Issue: 22 Pages: 12415-12435

The Pyrazolo[3,4-]pyrimidine-Based Kinase Inhibitor NVP-BHG712: Effects of Regioisomers on Tumor Growth, Perfusion, and Hypoxia in EphB4-Positive A375 Melanoma Xenografts.
Molecules (Basel, Switzerland)
Neuber C, Tröster A, Löser R, Belter B, Schwalbe H, Pietzsch J PubMed
Nov 2020 Volume: 25 Issue: 21 Pages:

Cysteine oxidation and disulfide formation in the ribosomal exit tunnel.
Nature communications
Schulte L, Mao J, Reitz J, Sreeramulu S, Kudlinzki D, Hodirnau VV, Meier-Credo J, Saxena K, Buhr F, Langer JD, Blackledge M, Frangakis AS, Glaubitz C, Schwalbe H PubMed
Nov 2020 Volume: 11 Issue: 1 Pages: 5569

Non-Invasive Measurement of Drug and 2-HG Signals Using F and H MR Spectroscopy in Brain Tumors Treated with the Mutant IDH1 Inhibitor BAY1436032.
Cancers
Wenger KJ, Richter C, Burger MC, Urban H, Kaulfuss S, Harter PN, Sreeramulu S, Schwalbe H, Steinbach JP, Hattingen E, Bähr O, Pilatus U PubMed
Oct 2020 Volume: 12 Issue: 11 Pages:

Site-specific dynamic nuclear polarization in a Gd(III)-labeled protein.
Physical chemistry chemical physics : PCCP
Heiliger J, Matzel T, Çetiner EC, Schwalbe H, Kuenze G, Corzilius B PubMed
Nov 2020 Volume: 22 Issue: 44 Pages: 25455-25466

Structural rearrangement of amyloid-β upon inhibitor binding suppresses formation of Alzheimer's disease related oligomers.
eLife
Lieblein T, Zangl R, Martin J, Hoffmann J, Hutchison MJ, Stark T, Stirnal E, Schrader T, Schwalbe H, Morgner N PubMed
Oct 2020 Volume: 9 Issue: Pages:

Sensitivity enhancement of homonuclear multidimensional NMR correlations for labile sites in proteins, polysaccharides, and nucleic acids.
Nature communications
Novakovic M, Kupče Ē, Oxenfarth A, Battistel MD, Freedberg DI, Schwalbe H, Frydman L PubMed
Oct 2020 Volume: 11 Issue: 1 Pages: 5317

In-Cell NMR Spectroscopy of Functional Riboswitch Aptamers in Eukaryotic Cells.
Angewandte Chemie (International ed. in English)
Broft P, Dzatko S, Krafcikova M, Wacker A, Hänsel-Hertsch R, Dötsch V, Trantirek L, Schwalbe H PubMed
Jan 2021 Volume: 60 Issue: 2 Pages: 865-872

NMR Spectroscopy of Large Functional RNAs: From Sample Preparation to Low-Gamma Detection.
Current protocols in nucleic acid chemistry
Schnieders R, Knezic B, Zetzsche H, Sudakov A, Matzel T, Richter C, Hengesbach M, Schwalbe H, Fürtig B PubMed
Sep 2020 Volume: 82 Issue: 1 Pages: e116

Biological functions, genetic and biochemical characterization, and NMR structure determination of the small zinc finger protein HVO_2753 from Haloferax volcanii.
The FEBS journal
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Mar 2021 Volume: 288 Issue: 6 Pages: 2042-2062

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Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)
Schlundt A, Wirtz MA, Knezic B, Hengesbach M, Fürtig B, Weigand JE, Wöhnert J, Ferner J, Saxena K, Wacker A, Richter C, Sreeramulu S, Wirmer-Bartoschek J, Schwalbe H, PubMed
2020 Volume: 26 Issue: 4 Pages: 440-441

F NMR-Based Fragment Screening for 14 Different Biologically Active RNAs and 10 DNA and Protein Counter-Screens.
Chembiochem : a European journal of chemical biology
Binas O, de Jesus V, Landgraf T, Völklein AE, Martins J, Hymon D, Kaur Bains J, Berg H, Biedenbänder T, Fürtig B, Lakshmi Gande S, Niesteruk A, Oxenfarth A, Shahin Qureshi N, Schamber T, Schnieders R, Tröster A, Wacker A, Wirmer-Bartoschek J, Wirtz Martin MA, Stirnal E, Azzaoui K, Richter C, Sreeramulu S, José Blommers MJ, Schwalbe H PubMed
Jan 2021 Volume: 22 Issue: 2 Pages: 423-433

Quantitative modeling of the function of kinetically driven transcriptional riboswitches.
Journal of theoretical biology
Parra-Rojas C, Fürtig B, Schwalbe H, Hernandez-Vargas EA PubMed
Dec 2020 Volume: 506 Issue: Pages: 110406

H, C, and N backbone chemical shift assignments of the nucleic acid-binding domain of SARS-CoV-2 non-structural protein 3e.
Biomolecular NMR assignments
Korn SM, Dhamotharan K, Fürtig B, Hengesbach M, Löhr F, Qureshi NS, Richter C, Saxena K, Schwalbe H, Tants JN, Weigand JE, Wöhnert J, Schlundt A PubMed
Oct 2020 Volume: 14 Issue: 2 Pages: 329-333

NMR Spectroscopic Characterization of the C-Mannose Conformation in a Thrombospondin Repeat Using a Selective Labeling Approach.
Angewandte Chemie (International ed. in English)
Jonker HRA, Saxena K, Shcherbakova A, Tiemann B, Bakker H, Schwalbe H PubMed
Nov 2020 Volume: 59 Issue: 46 Pages: 20659-20665

Refolding of Cold-Denatured Barstar Induced by Radio-Frequency Heating: A New Method to Study Protein Folding by Real-Time NMR Spectroscopy.
Angewandte Chemie (International ed. in English)
Pintér G, Schwalbe H PubMed
Dec 2020 Volume: 59 Issue: 49 Pages: 22086-22091

Anti-tyrosinase, anti-cholinesterase and cytotoxic activities of extracts and phytochemicals from the Tunisian Citharexylum spinosum L.: Molecular docking and SAR analysis.
Bioorganic chemistry
Saidi I, Nimbarte VD, Schwalbe H, Waffo-Téguo P, Harrath AH, Mansour L, Alwasel S, Ben Jannet H PubMed
Sep 2020 Volume: 102 Issue: Pages: 104093

Light Dynamics of the Retinal-Disease-Relevant G90D Bovine Rhodopsin Mutant.
Angewandte Chemie (International ed. in English)
Kubatova N, Mao J, Eckert CE, Saxena K, Gande SL, Wachtveitl J, Glaubitz C, Schwalbe H PubMed
Sep 2020 Volume: 59 Issue: 36 Pages: 15656-15664

NMR quality control of fragment libraries for screening.
Journal of biomolecular NMR
Sreeramulu S, Richter C, Kuehn T, Azzaoui K, Blommers MJJ, Del Conte R, Fragai M, Trieloff N, Schmieder P, Nazaré M, Specker E, Ivanov V, Oschkinat H, Banci L, Schwalbe H PubMed
Nov 2020 Volume: 74 Issue: 10-11 Pages: 555-563

Genetic Code Expansion Facilitates Position-Selective Modification of Nucleic Acids and Proteins.
ChemPlusChem
Müller D, Trucks S, Schwalbe H, Hengesbach M PubMed
Jun 2020 Volume: 85 Issue: 6 Pages: 1233-1243

Structural basis for the recognition of transiently structured AU-rich elements by Roquin.
Nucleic acids research
Binas O, Tants JN, Peter SA, Janowski R, Davydova E, Braun J, Niessing D, Schwalbe H, Weigand JE, Schlundt A PubMed
Jul 2020 Volume: 48 Issue: 13 Pages: 7385-7403

The conformational landscape of transcription intermediates involved in the regulation of the ZMP-sensing riboswitch from Thermosinus carboxydivorans.
Nucleic acids research
Binas O, Schamber T, Schwalbe H PubMed
Jul 2020 Volume: 48 Issue: 12 Pages: 6970-6979

Site-Specific Detection of Arginine Methylation in Highly Repetitive Protein Motifs of Low Sequence Complexity by NMR.
Journal of the American Chemical Society
Altincekic N, Löhr F, Meier-Credo J, Langer JD, Hengesbach M, Richter C, Schwalbe H PubMed
Apr 2020 Volume: 142 Issue: 16 Pages: 7647-7654

formation of transcriptional modulators using non-canonical DNA i-motifs.
Chemical science
Saha P, Panda D, Müller D, Maity A, Schwalbe H, Dash J PubMed
Feb 2020 Volume: 11 Issue: 8 Pages: 2058-2067

Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate-Based Inhibitors of Cytochrome bo Ubiquinol Oxidase from Escherichia coli.
ChemMedChem
Elamri I, Radloff M, Hohmann KF, Nimbarte VD, Nasiri HR, Bolte M, Safarian S, Michel H, Schwalbe H PubMed
Jul 2020 Volume: 15 Issue: 14 Pages: 1262-1271

Refolding through a Linear Transition State Enables Fast Temperature Adaptation of a Translational Riboswitch.
Biochemistry
Fürtig B, Oberhauser EM, Zetzsche H, Klötzner DP, Heckel A, Schwalbe H PubMed
Mar 2020 Volume: 59 Issue: 10 Pages: 1081-1086

A 300-fold enhancement of imino nucleic acid resonances by hyperpolarized water provides a new window for probing RNA refolding by 1D and 2D NMR.
Proceedings of the National Academy of Sciences of the United States of America
Novakovic M, Olsen GL, Pintér G, Hymon D, Fürtig B, Schwalbe H, Frydman L PubMed
Feb 2020 Volume: 117 Issue: 5 Pages: 2449-2455

Structure Validation of G-Rich RNAs in Noncoding Regions of the Human Genome.
Chembiochem : a European journal of chemical biology
Binas O, Bessi I, Schwalbe H PubMed
Jun 2020 Volume: 21 Issue: 11 Pages: 1656-1663

Conformational Dynamics of Strand Register Shifts in DNA G-Quadruplexes.
Journal of the American Chemical Society
Grün JT, Hennecker C, Klötzner DP, Harkness RW, Bessi I, Heckel A, Mittermaier AK, Schwalbe H PubMed
Jan 2020 Volume: 142 Issue: 1 Pages: 264-273

Real-Time NMR Spectroscopy for Studying Metabolism.
Angewandte Chemie (International ed. in English)
Alshamleh I, Krause N, Richter C, Kurrle N, Serve H, Günther UL, Schwalbe H PubMed
Feb 2020 Volume: 59 Issue: 6 Pages: 2304-2308

Rapid Biophysical Characterization and NMR Spectroscopy Structural Analysis of Small Proteins from Bacteria and Archaea.
Chembiochem : a European journal of chemical biology
Kubatova N, Pyper DJ, Jonker HRA, Saxena K, Remmel L, Richter C, Brantl S, Evguenieva-Hackenberg E, Hess WR, Klug G, Marchfelder A, Soppa J, Streit W, Mayzel M, Orekhov VY, Fuxreiter M, Schmitz RA, Schwalbe H PubMed
Apr 2020 Volume: 21 Issue: 8 Pages: 1178-1187

Genetic Code Expansion Facilitates Position-Selective Labeling of RNA for Biophysical Studies.
Chemistry (Weinheim an der Bergstrasse, Germany)
Hegelein A, Müller D, Größl S, Göbel M, Hengesbach M, Schwalbe H PubMed
Feb 2020 Volume: 26 Issue: 8 Pages: 1800-1810

G-Quadruplex-Specific Cell-Permeable Guanosine-Anthracene Conjugate Inhibits Telomere Elongation and Induces Apoptosis by Repressing the Gene.
Bioconjugate chemistry
Saha P, Kumar YP, Das T, Müller D, Bessi I, Schwalbe H, Dash J PubMed
Dec 2019 Volume: 30 Issue: 12 Pages: 3038-3045

Identification of Eph receptor signaling as a regulator of autophagy and a therapeutic target in colorectal carcinoma.
Molecular oncology
DiPrima M, Wang D, Tröster A, Maric D, Terrades-Garcia N, Ha T, Kwak H, Sanchez-Martin D, Kudlinzki D, Schwalbe H, Tosato G PubMed
Nov 2019 Volume: 13 Issue: 11 Pages: 2441-2459

Modular, triple-resonance, transmission line DNP MAS probe for 500 MHz/330 GHz.
Journal of magnetic resonance (San Diego, Calif. : 1997)
Reese M, George C, Yang C, Jawla S, Grün JT, Schwalbe H, Redfield C, Temkin RJ, Griffin RG PubMed
Oct 2019 Volume: 307 Issue: Pages: 106573

More than Proton Detection-New Avenues for NMR Spectroscopy of RNA.
Chemistry (Weinheim an der Bergstrasse, Germany)
Schnieders R, Keyhani S, Schwalbe H, Fürtig B PubMed
Jan 2020 Volume: 26 Issue: 1 Pages: 102-113

(±)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus P1210 Isolated from the Halophyte sp.
The Journal of organic chemistry
Shi YN, Pusch S, Shi YM, Richter C, Maciá-Vicente JG, Schwalbe H, Kaiser M, Opatz T, Bode HB PubMed
Sep 2019 Volume: 84 Issue: 17 Pages: 11203-11209

Metabolic Plasticity of Acute Myeloid Leukemia.
Cells
Kreitz J, Schönfeld C, Seibert M, Stolp V, Alshamleh I, Oellerich T, Steffen B, Schwalbe H, Schnütgen F, Kurrle N, Serve H PubMed
Jul 2019 Volume: 8 Issue: 8 Pages:

Molecular tuning of farnesoid X receptor partial agonism.
Nature communications
Merk D, Sreeramulu S, Kudlinzki D, Saxena K, Linhard V, Gande SL, Hiller F, Lamers C, Nilsson E, Aagaard A, Wissler L, Dekker N, Bamberg K, Schubert-Zsilavecz M, Schwalbe H PubMed
Jul 2019 Volume: 10 Issue: 1 Pages: 2915

Solution Structure and Dynamics of the Small Protein HVO_2922 from Haloferax volcanii.
Chembiochem : a European journal of chemical biology
Kubatova N, Jonker HRA, Saxena K, Richter C, Vogel V, Schreiber S, Marchfelder A, Schwalbe H PubMed
Jan 2020 Volume: 21 Issue: 1-2 Pages: 149-156

Novel C-detected NMR Experiments for the Precise Detection of RNA Structure.
Angewandte Chemie (International ed. in English)
Schnieders R, Wolter AC, Richter C, Wöhnert J, Schwalbe H, Fürtig B PubMed
Jul 2019 Volume: 58 Issue: 27 Pages: 9140-9144

"CodonWizard" - An intuitive software tool with graphical user interface for customizable codon optimization in protein expression efforts.
Protein expression and purification
Rehbein P, Berz J, Kreisel P, Schwalbe H PubMed
Aug 2019 Volume: 160 Issue: Pages: 84-93

Identification of primary and secondary metabolites and transcriptome profile of soybean tissues during different stages of hypoxia.
Data in brief
Coutinho ID, Henning LMM, Döpp SA, Nepomuceno A, Moraes LAC, Marcolino-Gomes J, Richter C, Schwalbe H, Colnago LA PubMed
Dec 2018 Volume: 21 Issue: Pages: 1089-1100

Combined smFRET and NMR analysis of riboswitch structural dynamics.
Methods (San Diego, Calif.)
Bains JK, Blechar J, de Jesus V, Meiser N, Zetzsche H, Fürtig B, Schwalbe H, Hengesbach M PubMed
Jan 2019 Volume: 153 Issue: Pages: 22-34

A New Photocaged Puromycin for an Efficient Labeling of Newly Translated Proteins in Living Neurons.
Chembiochem : a European journal of chemical biology
Elamri I, Heumüller M, Herzig LM, Stirnal E, Wachtveitl J, Schuman EM, Schwalbe H PubMed
Dec 2018 Volume: 19 Issue: 23 Pages: 2458-2464

Optimal Destabilization of DNA Double Strands by Single-Nucleobase Caging.
Chemistry (Weinheim an der Bergstrasse, Germany)
Seyfried P, Heinz M, Pintér G, Klötzner DP, Becker Y, Bolte M, Jonker HRA, Stelzl LS, Hummer G, Schwalbe H, Heckel A PubMed
Nov 2018 Volume: 24 Issue: 66 Pages: 17568-17576

Conformational switch in the ribosomal protein S1 guides unfolding of structured RNAs for translation initiation.
Nucleic acids research
Qureshi NS, Bains JK, Sreeramulu S, Schwalbe H, Fürtig B PubMed
Nov 2018 Volume: 46 Issue: 20 Pages: 10917-10929

Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria.
PloS one
Muthukumar Y, Münkemer J, Mathieu D, Richter C, Schwalbe H, Steinmetz H, Kessler W, Reichelt J, Beutling U, Frank R, Büssow K, van den Heuvel J, Brönstrup M, Taylor RE, Laschat S, Sasse F PubMed
2018 Volume: 13 Issue: 7 Pages: e0201605

On the Implication of Water on Fragment-to-Ligand Growth in Kinase Binding Thermodynamics.
ChemMedChem
Wienen-Schmidt B, Wulsdorf T, Jonker HRA, Saxena K, Kudlinzki D, Linhard V, Sreeramulu S, Heine A, Schwalbe H, Klebe G PubMed
Sep 2018 Volume: 13 Issue: 18 Pages: 1988-1996

Chemo-Enzymatic Synthesis of Position-Specifically Modified RNA for Biophysical Studies including Light Control and NMR Spectroscopy.
Angewandte Chemie (International ed. in English)
Keyhani S, Goldau T, Blümler A, Heckel A, Schwalbe H PubMed
Sep 2018 Volume: 57 Issue: 37 Pages: 12017-12021

NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
ChemMedChem
Tröster A, Heinzlmeir S, Berger BT, Gande SL, Saxena K, Sreeramulu S, Linhard V, Nasiri AH, Bolte M, Müller S, Kuster B, Médard G, Kudlinzki D, Schwalbe H PubMed
Aug 2018 Volume: 13 Issue: 16 Pages: 1629-1633

Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds.
ACS chemical biology
Raab M, Sanhaji M, Pietsch L, Béquignon I, Herbrand AK, Süß E, Gande SL, Caspar B, Kudlinzki D, Saxena K, Sreeramulu S, Schwalbe H, Strebhardt K, Biondi RM PubMed
Aug 2018 Volume: 13 Issue: 8 Pages: 1921-1931

Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug-Kinase Binding.
Journal of medicinal chemistry
Wienen-Schmidt B, Jonker HRA, Wulsdorf T, Gerber HD, Saxena K, Kudlinzki D, Sreeramulu S, Parigi G, Luchinat C, Heine A, Schwalbe H, Klebe G PubMed
Jul 2018 Volume: 61 Issue: 14 Pages: 5922-5933

The domain architecture of PtkA, the first tyrosine kinase from , differs from the conventional kinase architecture.
The Journal of biological chemistry
Niesteruk A, Jonker HRA, Richter C, Linhard V, Sreeramulu S, Schwalbe H PubMed
Jul 2018 Volume: 293 Issue: 30 Pages: 11823-11836

Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes.
Nature communications
Garcia-Lopez A, Tessaro F, Jonker HRA, Wacker A, Richter C, Comte A, Berntenis N, Schmucki R, Hatje K, Petermann O, Chiriano G, Perozzo R, Sciarra D, Konieczny P, Faustino I, Fournet G, Orozco M, Artero R, Metzger F, Ebeling M, Goekjian P, Joseph B, Schwalbe H, Scapozza L PubMed
May 2018 Volume: 9 Issue: 1 Pages: 2032

iNEXT: a European facility network to stimulate translational structural biology.
FEBS letters
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Jun 2018 Volume: 592 Issue: 12 Pages: 1909-1917

Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex.
Nucleic acids research
Dutta D, Debnath M, Müller D, Paul R, Das T, Bessi I, Schwalbe H, Dash J PubMed
Jun 2018 Volume: 46 Issue: 11 Pages: 5355-5365

Improved high-yield expression, purification and refolding of recombinant mammalian prion proteins under aerosol-free elevated biological safety conditions.
Protein expression and purification
Rehbein P, Schwalbe H PubMed
Oct 2018 Volume: 150 Issue: Pages: 53-60

Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor.
Chemistry (Weinheim an der Bergstrasse, Germany)
Kappert F, Sreeramulu S, Jonker HRA, Richter C, Rogov VV, Proschak E, Hargittay B, Saxena K, Schwalbe H PubMed
Jun 2018 Volume: 24 Issue: 31 Pages: 7861-7865

Life times of metastable states guide regulatory signaling in transcriptional riboswitches.
Nature communications
Helmling C, Klötzner DP, Sochor F, Mooney RA, Wacker A, Landick R, Fürtig B, Heckel A, Schwalbe H PubMed
Mar 2018 Volume: 9 Issue: 1 Pages: 944

Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A.
FEBS letters
Niesteruk A, Hutchison M, Sreeramulu S, Jonker HRA, Richter C, Abele R, Bock C, Schwalbe H PubMed
Apr 2018 Volume: 592 Issue: 7 Pages: 1233-1245

Georatusin, a Specific Antiparasitic Polyketide-Peptide Hybrid from the Fungus Geomyces auratus.
Organic letters
Shi YM, Richter C, Challinor VL, Grün P, Girela Del Rio A, Kaiser M, Schüffler A, Piepenbring M, Schwalbe H, Bode HB PubMed
Mar 2018 Volume: 20 Issue: 6 Pages: 1563-1567

Human Telomeric G-Quadruplex Selective Fluoro-Isoquinolines Induce Apoptosis in Cancer Cells.
Bioconjugate chemistry
Maiti S, Saha P, Das T, Bessi I, Schwalbe H, Dash J PubMed
Apr 2018 Volume: 29 Issue: 4 Pages: 1141-1154

The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nature chemical biology
Joedicke L, Mao J, Kuenze G, Reinhart C, Kalavacherla T, Jonker HRA, Richter C, Schwalbe H, Meiler J, Preu J, Michel H, Glaubitz C PubMed
Mar 2018 Volume: 14 Issue: 3 Pages: 284-290

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Chemistry (Weinheim an der Bergstrasse, Germany)
Toal SE, Kubatova N, Richter C, Linhard V, Schwalbe H, Schweitzer-Stenner R PubMed
Dec 2017 Volume: 23 Issue: 71 Pages: 18084-18087

Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding.
Chembiochem : a European journal of chemical biology
Lehner F, Kudlinzki D, Richter C, Müller-Werkmeister HM, Eberl KB, Bredenbeck J, Schwalbe H, Silvers R PubMed
Dec 2017 Volume: 18 Issue: 23 Pages: 2340-2350

Evaluation of N-detected H-N correlation experiments on increasingly large RNAs.
Journal of biomolecular NMR
Schnieders R, Richter C, Warhaut S, de Jesus V, Keyhani S, Duchardt-Ferner E, Keller H, Wöhnert J, Kuhn LT, Breeze AL, Bermel W, Schwalbe H, Fürtig B PubMed
Sep 2017 Volume: 69 Issue: 1 Pages: 31-44

Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence.
Chembiochem : a European journal of chemical biology
Lannes L, Young P, Richter C, Morgner N, Schwalbe H PubMed
Oct 2017 Volume: 18 Issue: 20 Pages: 2033-2044

Editorial: New 1.2 GHz NMR Spectrometers- New Horizons?
Angewandte Chemie (International ed. in English)
Schwalbe H PubMed
Aug 2017 Volume: 56 Issue: 35 Pages: 10252-10253

Mistakes in translation: Reflections on mechanism.
PloS one
Liu Y, Sharp JS, Do DH, Kahn RA, Schwalbe H, Buhr F, Prestegard JH PubMed
2017 Volume: 12 Issue: 6 Pages: e0180566

Correction for Doller et al., "Tandem Phosphorylation of Serines 221 and 318 by Protein Kinase Cδ Coordinates mRNA Binding and Nucleocytoplasmic Shuttling of HuR".
Molecular and cellular biology
Doller A, Schlepckow K, Schwalbe H, Pfeilschifter J, Eberhardt W PubMed
Jul 2017 Volume: 37 Issue: 13 Pages:

Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem
Heinzlmeir S, Lohse J, Treiber T, Kudlinzki D, Linhard V, Gande SL, Sreeramulu S, Saxena K, Liu X, Wilhelm M, Schwalbe H, Kuster B, Médard G PubMed
Jun 2017 Volume: 12 Issue: 12 Pages: 999-1011

Unprecedented Carbon Signal Enhancement in Liquid-State NMR Spectroscopy.
Angewandte Chemie (International ed. in English)
Pintér G, Schwalbe H PubMed
Jul 2017 Volume: 56 Issue: 29 Pages: 8332-8334

Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation.
eLife
Steinert H, Sochor F, Wacker A, Buck J, Helmling C, Hiller F, Keyhani S, Noeske J, Grimm S, Rudolph MM, Keller H, Mooney RA, Landick R, Suess B, Fürtig B, Wöhnert J, Schwalbe H PubMed
May 2017 Volume: 6 Issue: Pages:

Conformational dynamics and alignment properties of loop lanthanide-binding-tags (LBTs) studied in interleukin-1β.
Journal of biomolecular NMR
Barthelmes D, Barthelmes K, Schnorr K, Jonker HRA, Bodmer B, Allen KN, Imperiali B, Schwalbe H PubMed
Jul 2017 Volume: 68 Issue: 3 Pages: 187-194

Probing the Conformation-Dependent Preferential Binding of Ethanol to Cationic Glycylalanylglycine in Water/Ethanol by Vibrational and NMR Spectroscopy.
The journal of physical chemistry. B
DiGuiseppi D, Milorey B, Lewis G, Kubatova N, Farrell S, Schwalbe H, Schweitzer-Stenner R PubMed
Jun 2017 Volume: 121 Issue: 23 Pages: 5744-5758

Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding.
Angewandte Chemie (International ed. in English)
Wirmer-Bartoschek J, Bendel LE, Jonker HRA, Grün JT, Papi F, Bazzicalupi C, Messori L, Gratteri P, Schwalbe H PubMed
Jun 2017 Volume: 56 Issue: 25 Pages: 7102-7106

Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Gö66.
Angewandte Chemie (International ed. in English)
Cai X, Shi YM, Pöhlmann N, Revermann O, Bahner I, Pidot SJ, Wesche F, Lackner H, Büchel C, Kaiser M, Richter C, Schwalbe H, Stinear TP, Zeeck A, Bode HB PubMed
Apr 2017 Volume: 56 Issue: 18 Pages: 4945-4949

Ligand-modulated folding of the full-length adenine riboswitch probed by NMR and single-molecule FRET spectroscopy.
Nucleic acids research
Warhaut S, Mertinkus KR, Höllthaler P, Fürtig B, Heilemann M, Hengesbach M, Schwalbe H PubMed
May 2017 Volume: 45 Issue: 9 Pages: 5512-5522

NMR Structural Profiling of Transcriptional Intermediates Reveals Riboswitch Regulation by Metastable RNA Conformations.
Journal of the American Chemical Society
Helmling C, Wacker A, Wolfinger MT, Hofacker IL, Hengesbach M, Fürtig B, Schwalbe H PubMed
Feb 2017 Volume: 139 Issue: 7 Pages: 2647-2656

Ligand binding to 2΄-deoxyguanosine sensing riboswitch in metabolic context.
Nucleic acids research
Kim YB, Wacker A, Laer KV, Rogov VV, Suess B, Schwalbe H PubMed
May 2017 Volume: 45 Issue: 9 Pages: 5375-5386

Heteronuclear Cross-Relaxation under Solid-State Dynamic Nuclear Polarization.
Journal of the American Chemical Society
Daube D, Aladin V, Heiliger J, Wittmann JJ, Barthelmes D, Bengs C, Schwalbe H, Corzilius B PubMed
Dec 2016 Volume: 138 Issue: 51 Pages: 16572-16575

The Absence of the N-acyl-homoserine-lactone Autoinducer Synthase Genes and Increases the Copy Number of the Symbiotic Plasmid in NGR234.
Frontiers in microbiology
Grote J, Krysciak D, Petersen K, Güllert S, Schmeisser C, Förstner KU, Krishnan HB, Schwalbe H, Kubatova N, Streit WR PubMed
2016 Volume: 7 Issue: Pages: 1858

Conserved small mRNA with an unique, extended Shine-Dalgarno sequence.
RNA biology
Hahn J, Thalmann S, Migur A, von Boeselager RF, Kubatova N, Kubareva E, Schwalbe H, Evguenieva-Hackenberg E PubMed
Oct 2017 Volume: 14 Issue: 10 Pages: 1353-1363

Terphenyl Derivatives from Allantophomopsis lycopodina.
Journal of natural products
Andernach L, Sandjo LP, Liermann JC, Schlämann R, Richter C, Ferner JP, Schwalbe H, Schüffler A, Thines E, Opatz T PubMed
Oct 2016 Volume: 79 Issue: 10 Pages: 2718-2725

Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS chemical biology
Heinzlmeir S, Kudlinzki D, Sreeramulu S, Klaeger S, Gande SL, Linhard V, Wilhelm M, Qiao H, Helm D, Ruprecht B, Saxena K, Médard G, Schwalbe H, Kuster B PubMed
Dec 2016 Volume: 11 Issue: 12 Pages: 3400-3411

Expression and Purification of EPHA2 Tyrosine Kinase Domain for Crystallographic and NMR Studies.
Chembiochem : a European journal of chemical biology
Gande SL, Saxena K, Sreeramulu S, Linhard V, Kudlinzki D, Heinzlmeir S, Reichert AJ, Skerra A, Kuster B, Schwalbe H PubMed
Dec 2016 Volume: 17 Issue: 23 Pages: 2257-2263

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Nature medicine
Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella FF, Jaé N, Rossbach O, Amrhein C, Sigala F, Boon RA, Fürtig B, Manavski Y, You X, Uchida S, Keller T, Boeckel JN, Franco-Cereceda A, Maegdefessel L, Chen W, Schwalbe H, Bindereif A, Eriksson P, Hedin U, Zeiher AM, Dimmeler S PubMed
Oct 2016 Volume: 22 Issue: 10 Pages: 1140-1150

Gd(iii) and Mn(ii) complexes for dynamic nuclear polarization: small molecular chelate polarizing agents and applications with site-directed spin labeling of proteins.
Physical chemistry chemical physics : PCCP
Kaushik M, Bahrenberg T, Can TV, Caporini MA, Silvers R, Heiliger J, Smith AA, Schwalbe H, Griffin RG, Corzilius B PubMed
Oct 2016 Volume: 18 Issue: 39 Pages: 27205-27218

Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling.
Cancer cell
Herbert C, Schieborr U, Saxena K, Juraszek J, De Smet F, Alcouffe C, Bianciotto M, Saladino G, Sibrac D, Kudlinzki D, Sreeramulu S, Brown A, Rigon P, Herault JP, Lassalle G, Blundell TL, Rousseau F, Gils A, Schymkowitz J, Tompa P, Herbert JM, Carmeliet P, Gervasio FL, Schwalbe H, Bono F PubMed
Jul 2016 Volume: 30 Issue: 1 Pages: 176-178

Synthesis of Fluorescent Binaphthyl Amines That Bind c-MYC G-Quadruplex DNA and Repress c-MYC Expression.
Journal of medicinal chemistry
Chauhan A, Paul R, Debnath M, Bessi I, Mandal S, Schwalbe H, Dash J PubMed
Aug 2016 Volume: 59 Issue: 15 Pages: 7275-81

Reduced and mutant lysozyme refolding with lipid vesicles. Model study of disulfide impact on equilibria and dynamics.
Biochimica et biophysica acta
Zhu W, Silvers R, Schwalbe H, Keiderling TA PubMed
Sep 2016 Volume: 1864 Issue: 9 Pages: 1083-1092

Small molecule regulated dynamic structural changes of human G-quadruplexes.
Chemical science
Debnath M, Ghosh S, Panda D, Bessi I, Schwalbe H, Bhattacharyya K, Dash J PubMed
May 2016 Volume: 7 Issue: 5 Pages: 3279-3285

Understanding How DNA Enzymes Work.
Angewandte Chemie (International ed. in English)
Wirmer-Bartoschek J, Schwalbe H PubMed
Apr 2016 Volume: 55 Issue: 18 Pages: 5376-7

Direct ¹³C-detected NMR experiments for mapping and characterization of hydrogen bonds in RNA.
Journal of biomolecular NMR
Fürtig B, Schnieders R, Richter C, Zetzsche H, Keyhani S, Helmling C, Kovacs H, Schwalbe H PubMed
Mar 2016 Volume: 64 Issue: 3 Pages: 207-21

Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations.
Molecular cell
Buhr F, Jha S, Thommen M, Mittelstaet J, Kutz F, Schwalbe H, Rodnina MV, Komar AA PubMed
Feb 2016 Volume: 61 Issue: 3 Pages: 341-351

Corrigendum to "The cytochrome c peroxidase and cytochrome c encounter complex: The other side of the story" [FEBS Lett. 588 (2014) 1873-1878].
FEBS letters
Schilder J, Löhr F, Schwalbe H, Ubbink M PubMed
Jul 2015 Volume: 589 Issue: 16 Pages: 2169

Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.
Angewandte Chemie (International ed. in English)
Thevarpadam J, Bessi I, Binas O, Gonçalves DP, Slavov C, Jonker HR, Richter C, Wachtveitl J, Schwalbe H, Heckel A PubMed
Feb 2016 Volume: 55 Issue: 8 Pages: 2738-42

Fluorescent Dansyl-Guanosine Conjugates that Bind c-MYC Promoter G-Quadruplex and Downregulate c-MYC Expression.
Chembiochem : a European journal of chemical biology
Pavan Kumar Y, Saha P, Saha D, Bessi I, Schwalbe H, Chowdhury S, Dash J PubMed
Mar 2016 Volume: 17 Issue: 5 Pages: 388-93

Structural investigations of the p53/p73 homologs from the tunicate species Ciona intestinalis reveal the sequence requirements for the formation of a tetramerization domain.
Protein science : a publication of the Protein Society
Heering J, Jonker HR, Löhr F, Schwalbe H, Dötsch V PubMed
Feb 2016 Volume: 25 Issue: 2 Pages: 410-22

Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids.
Angewandte Chemie (International ed. in English)
Schimming O, Challinor VL, Tobias NJ, Adihou H, Grün P, Pöschel L, Richter C, Schwalbe H, Bode HB PubMed
Oct 2015 Volume: 54 Issue: 43 Pages: 12702-5

Influence of Arrestin on the Photodecay of Bovine Rhodopsin.
Angewandte Chemie (International ed. in English)
Chatterjee D, Eckert CE, Slavov C, Saxena K, Fürtig B, Sanders CR, Gurevich VV, Wachtveitl J, Schwalbe H PubMed
Nov 2015 Volume: 54 Issue: 46 Pages: 13555-60

Encoded loop-lanthanide-binding tags for long-range distance measurements in proteins by NMR and EPR spectroscopy.
Journal of biomolecular NMR
Barthelmes D, Gränz M, Barthelmes K, Allen KN, Imperiali B, Prisner T, Schwalbe H PubMed
Nov 2015 Volume: 63 Issue: 3 Pages: 275-82

A Nucleus-Imaging Probe That Selectively Stabilizes a Minor Conformation of c-MYC G-quadruplex and Down-regulates c-MYC Transcription in Human Cancer Cells.
Scientific reports
Panda D, Debnath M, Mandal S, Bessi I, Schwalbe H, Dash J PubMed
Aug 2015 Volume: 5 Issue: Pages: 13183

Optimized Plk1 PBD Inhibitors Based on Poloxin Induce Mitotic Arrest and Apoptosis in Tumor Cells.
ACS chemical biology
Scharow A, Raab M, Saxena K, Sreeramulu S, Kudlinzki D, Gande S, Dötsch C, Kurunci-Csacsko E, Klaeger S, Kuster B, Schwalbe H, Strebhardt K, Berg T PubMed
Nov 2015 Volume: 10 Issue: 11 Pages: 2570-9

High-resolution crystal structure of cAMP-dependent protein kinase from Cricetulus griseus.
Acta crystallographica. Section F, Structural biology communications
Kudlinzki D, Linhard VL, Saxena K, Sreeramulu S, Gande S, Schieborr U, Dreyer M, Schwalbe H PubMed
Aug 2015 Volume: 71 Issue: Pt 8 Pages: 1088-93

Enlightening the photoactive site of channelrhodopsin-2 by DNP-enhanced solid-state NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America
Becker-Baldus J, Bamann C, Saxena K, Gustmann H, Brown LJ, Brown RC, Reiter C, Bamberg E, Wachtveitl J, Schwalbe H, Glaubitz C PubMed
Aug 2015 Volume: 112 Issue: 32 Pages: 9896-901

Rapid NMR screening of RNA secondary structure and binding.
Journal of biomolecular NMR
Helmling C, Keyhani S, Sochor F, Fürtig B, Hengesbach M, Schwalbe H PubMed
Sep 2015 Volume: 63 Issue: 1 Pages: 67-76

Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy.
Angewandte Chemie (International ed. in English)
Ardenkjaer-Larsen JH, Boebinger GS, Comment A, Duckett S, Edison AS, Engelke F, Griesinger C, Griffin RG, Hilty C, Maeda H, Parigi G, Prisner T, Ravera E, van Bentum J, Vega S, Webb A, Luchinat C, Schwalbe H, Frydman L PubMed
Aug 2015 Volume: 54 Issue: 32 Pages: 9162-85

Gerhard Quinkert (1927-2015).
Angewandte Chemie (International ed. in English)
Göbel M, Schwalbe H PubMed
Jul 2015 Volume: 54 Issue: 30 Pages: 8597

Involvement of Long-Lived Intermediate States in the Complex Folding Pathway of the Human Telomeric G-Quadruplex.
Angewandte Chemie (International ed. in English)
Bessi I, Jonker HR, Richter C, Schwalbe H PubMed
Jul 2015 Volume: 54 Issue: 29 Pages: 8444-8

Tuning the pH Response of i-Motif DNA Oligonucleotides.
Chembiochem : a European journal of chemical biology
Lannes L, Halder S, Krishnan Y, Schwalbe H PubMed
Jul 2015 Volume: 16 Issue: 11 Pages: 1647-56

Structure and Biophysical Characterization of the S-Adenosylmethionine-dependent O-Methyltransferase PaMTH1, a Putative Enzyme Accumulating during Senescence of Podospora anserina.
The Journal of biological chemistry
Chatterjee D, Kudlinzki D, Linhard V, Saxena K, Schieborr U, Gande SL, Wurm JP, Wöhnert J, Abele R, Rogov VV, Dötsch V, Osiewacz HD, Sreeramulu S, Schwalbe H PubMed
Jun 2015 Volume: 290 Issue: 26 Pages: 16415-30

Mechanistic insights into temperature-dependent regulation of the simple cyanobacterial hsp17 RNA thermometer at base-pair resolution.
Nucleic acids research
Wagner D, Rinnenthal J, Narberhaus F, Schwalbe H PubMed
Jun 2015 Volume: 43 Issue: 11 Pages: 5572-85

Differential scanning fluorimetry for monitoring RNA stability.
Chembiochem : a European journal of chemical biology
Silvers R, Keller H, Schwalbe H, Hengesbach M PubMed
May 2015 Volume: 16 Issue: 7 Pages: 1109-14

Water-soluble Py-BIPS spiropyrans as photoswitches for biological applications.
Organic letters
Özçoban C, Halbritter T, Steinwand S, Herzig LM, Kohl-Landgraf J, Askari N, Groher F, Fürtig B, Richter C, Schwalbe H, Suess B, Wachtveitl J, Heckel A PubMed
Mar 2015 Volume: 17 Issue: 6 Pages: 1517-20

Randomizing the unfolded state of peptides (and proteins) by nearest neighbor interactions between unlike residues.
Chemistry (Weinheim an der Bergstrasse, Germany)
Toal SE, Kubatova N, Richter C, Linhard V, Schwalbe H, Schweitzer-Stenner R PubMed
Mar 2015 Volume: 21 Issue: 13 Pages: 5173-92

Multiple conformational states of riboswitches fine-tune gene regulation.
Current opinion in structural biology
Fürtig B, Nozinovic S, Reining A, Schwalbe H PubMed
Feb 2015 Volume: 30 Issue: Pages: 112-124

Design of photocaged puromycin for nascent polypeptide release and spatiotemporal monitoring of translation.
Angewandte Chemie (International ed. in English)
Buhr F, Kohl-Landgraf J, tom Dieck S, Hanus C, Chatterjee D, Hegelein A, Schuman EM, Wachtveitl J, Schwalbe H PubMed
Mar 2015 Volume: 54 Issue: 12 Pages: 3717-21

Characterization of conformational dynamics of bistable RNA by equilibrium and non-equilibrium NMR.
Current protocols in nucleic acid chemistry
Fürtig B, Reining A, Sochor F, Oberhauser EM, Heckel A, Schwalbe H PubMed
Dec 2014 Volume: 55 Issue: Pages: 11.13.1-16

A temperature-jump NMR probe setup using rf heating optimized for the analysis of temperature-induced biomacromolecular kinetic processes.
Journal of magnetic resonance (San Diego, Calif. : 1997)
Rinnenthal J, Wagner D, Marquardsen T, Krahn A, Engelke F, Schwalbe H PubMed
Feb 2015 Volume: 251 Issue: Pages: 84-93

Structural biology. Mechanistic insight from the crystal structure of mitochondrial complex I.
Science (New York, N.Y.)
Zickermann V, Wirth C, Nasiri H, Siegmund K, Schwalbe H, Hunte C, Brandt U PubMed
Jan 2015 Volume: 347 Issue: 6217 Pages: 44-9

Integrated protocol for reliable and fast quantification and documentation of electrophoresis gels.
Protein expression and purification
Rehbein P, Schwalbe H PubMed
Jun 2015 Volume: 110 Issue: Pages: 1-6

Fragment based search for small molecule inhibitors of HIV-1 Tat-TAR.
Bioorganic & medicinal chemistry letters
Zeiger M, Stark S, Kalden E, Ackermann B, Ferner J, Scheffer U, Shoja-Bazargani F, Erdel V, Schwalbe H, Göbel MW PubMed
Dec 2014 Volume: 24 Issue: 24 Pages: 5576-5580

Membrane-binding mechanism of a bacterial phospholipid N-methyltransferase.
Molecular microbiology
Danne L, Aktas M, Gleichenhagen J, Grund N, Wagner D, Schwalbe H, Hoffknecht B, Metzler-Nolte N, Narberhaus F PubMed
Jan 2015 Volume: 95 Issue: 2 Pages: 313-31

The importance of helix P1 stability for structural pre-organization and ligand binding affinity of the adenine riboswitch aptamer domain.
RNA biology
Nozinovic S, Reining A, Kim YB, Noeske J, Schlepckow K, Wöhnert J, Schwalbe H PubMed
2014 Volume: 11 Issue: 5 Pages: 655-6

Protocol for aerosol-free recombinant production and NMR analysis of prion proteins.
Journal of biomolecular NMR
Rehbein P, Saxena K, Schlepckow K, Schwalbe H PubMed
Jun 2014 Volume: 59 Issue: 2 Pages: 111-7

The cytochrome c peroxidase and cytochrome c encounter complex: the other side of the story.
FEBS letters
Schilder J, Löhr F, Schwalbe H, Ubbink M PubMed
May 2014 Volume: 588 Issue: 10 Pages: 1873-8

Noncovalent spin labeling of riboswitch RNAs to obtain long-range structural NMR restraints.
ACS chemical biology
Helmling C, Bessi I, Wacker A, Schnorr KA, Jonker HR, Richter C, Wagner D, Kreibich M, Schwalbe H PubMed
Jun 2014 Volume: 9 Issue: 6 Pages: 1330-9

Structure determination of noncanonical RNA motifs guided by ¹H NMR chemical shifts.
Nature methods
Sripakdeevong P, Cevec M, Chang AT, Erat MC, Ziegeler M, Zhao Q, Fox GE, Gao X, Kennedy SD, Kierzek R, Nikonowicz EP, Schwalbe H, Sigel RK, Turner DH, Das R PubMed
Apr 2014 Volume: 11 Issue: 4 Pages: 413-6

Mechanism of the photoinduced uncaging reaction of puromycin protected by a 6-nitroveratryloxycarbonyl group.
Journal of the American Chemical Society
Kohl-Landgraf J, Buhr F, Lefrancois D, Mewes JM, Schwalbe H, Dreuw A, Wachtveitl J PubMed
Mar 2014 Volume: 136 Issue: 9 Pages: 3430-8

Characterization of the simultaneous decay kinetics of metarhodopsin states II and III in rhodopsin by solution-state NMR spectroscopy.
Angewandte Chemie (International ed. in English)
Stehle J, Silvers R, Werner K, Chatterjee D, Gande S, Scholz F, Dutta A, Wachtveitl J, Klein-Seetharaman J, Schwalbe H PubMed
Feb 2014 Volume: 53 Issue: 8 Pages: 2078-84

Structural basis for regulation of ribosomal RNA 2'-o-methylation.
Angewandte Chemie (International ed. in English)
Hengesbach M, Schwalbe H PubMed
Feb 2014 Volume: 53 Issue: 7 Pages: 1742-4

Influence of the absolute configuration of npe-caged cytosine on DNA single base pair stability.
Angewandte Chemie (International ed. in English)
Steinert HS, Schäfer F, Jonker HR, Heckel A, Schwalbe H PubMed
Jan 2014 Volume: 53 Issue: 4 Pages: 1072-5

Design, synthesis, and biological testing of novel naphthoquinones as substrate-based inhibitors of the quinol/fumarate reductase from Wolinella succinogenes.
Journal of medicinal chemistry
Nasiri HR, Madej MG, Panisch R, Lafontaine M, Bats JW, Lancaster CR, Schwalbe H PubMed
Dec 2013 Volume: 56 Issue: 23 Pages: 9530-41

RNA refolding studied by light-coupled NMR spectroscopy.
Methods in molecular biology (Clifton, N.J.)
Schwalbe H, Fürtig B PubMed
2014 Volume: 1086 Issue: Pages: 309-19

Magnetic resonance spectroscopy in bio(in)organic chemistry and in mechanistic systems biology: a tribute to Ivano Bertini.
Chembiochem : a European journal of chemical biology
Schwalbe H, Telser J PubMed
Sep 2013 Volume: 14 Issue: 14 Pages: 1671-5

Molecular mechanism of prion protein oligomerization at atomic resolution.
Angewandte Chemie (International ed. in English)
Schlepckow K, Schwalbe H PubMed
Sep 2013 Volume: 52 Issue: 38 Pages: 10002-5

A fluorescent guanosine dinucleoside as a selective switch-on sensor for c-myc G-quadruplex DNA with potent anticancer activities.
Chemistry (Weinheim an der Bergstrasse, Germany)
Kumar YP, Bhowmik S, Das RN, Bessi I, Paladhi S, Ghosh R, Schwalbe H, Dash J PubMed
Aug 2013 Volume: 19 Issue: 35 Pages: 11502-6

Detecting intracellular cysteine redox states by in-cell NMR spectroscopy.
Chembiochem : a European journal of chemical biology
Silvers R, Schwalbe H PubMed
Sep 2013 Volume: 14 Issue: 14 Pages: 1705-7

The structure of the cytochrome p450cam-putidaredoxin complex determined by paramagnetic NMR spectroscopy and crystallography.
Journal of molecular biology
Hiruma Y, Hass MA, Kikui Y, Liu WM, Ölmez B, Skinner SP, Blok A, Kloosterman A, Koteishi H, Löhr F, Schwalbe H, Nojiri M, Ubbink M PubMed
Nov 2013 Volume: 425 Issue: 22 Pages: 4353-65

MOTOR: model assisted software for NMR structure determination.
Proteins
Schieborr U, Sreeramulu S, Elshorst B, Maurer M, Saxena K, Stehle T, Kudlinzki D, Gande SL, Schwalbe H PubMed
Nov 2013 Volume: 81 Issue: 11 Pages: 2007-22

Kinase in motion: insights into the dynamic nature of p38α by high-pressure NMR spectroscopic studies.
Chembiochem : a European journal of chemical biology
Nielsen G, Jonker HR, Vajpai N, Grzesiek S, Schwalbe H PubMed
Sep 2013 Volume: 14 Issue: 14 Pages: 1799-806

Three-state mechanism couples ligand and temperature sensing in riboswitches.
Nature
Reining A, Nozinovic S, Schlepckow K, Buhr F, Fürtig B, Schwalbe H PubMed
Jul 2013 Volume: 499 Issue: 7458 Pages: 355-9

Optimizing the kinetics and thermodynamics of DNA i-motif folding.
Chembiochem : a European journal of chemical biology
Lieblein AL, Fürtig B, Schwalbe H PubMed
Jul 2013 Volume: 14 Issue: 10 Pages: 1226-30

Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.
Cancer cell
Herbert C, Schieborr U, Saxena K, Juraszek J, De Smet F, Alcouffe C, Bianciotto M, Saladino G, Sibrac D, Kudlinzki D, Sreeramulu S, Brown A, Rigon P, Herault JP, Lassalle G, Blundell TL, Rousseau F, Gils A, Schymkowitz J, Tompa P, Herbert JM, Carmeliet P, Gervasio FL, Schwalbe H, Bono F PubMed
Apr 2013 Volume: 23 Issue: 4 Pages: 489-501

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.
Cancer cell
Bono F, De Smet F, Herbert C, De Bock K, Georgiadou M, Fons P, Tjwa M, Alcouffe C, Ny A, Bianciotto M, Jonckx B, Murakami M, Lanahan AA, Michielsen C, Sibrac D, Dol-Gleizes F, Mazzone M, Zacchigna S, Herault JP, Fischer C, Rigon P, Ruiz de Almodovar C, Claes F, Blanc I, Poesen K, Zhang J, Segura I, Gueguen G, Bordes MF, Lambrechts D, Broussy R, van de Wouwer M, Michaux C, Shimada T, Jean I, Blacher S, Noel A, Motte P, Rom E, Rakic JM, Katsuma S, Schaeffer P, Yayon A, Van Schepdael A, Schwalbe H,... PubMed
Apr 2013 Volume: 23 Issue: 4 Pages: 477-88

Small-molecule binding sites on proteins established by paramagnetic NMR spectroscopy.
Journal of the American Chemical Society
Guan JY, Keizers PH, Liu WM, Löhr F, Skinner SP, Heeneman EA, Schwalbe H, Ubbink M, Siegal G PubMed
Apr 2013 Volume: 135 Issue: 15 Pages: 5859-68

Disorder and order in unfolded and disordered peptides and proteins: a view derived from tripeptide conformational analysis. II. Tripeptides with short side chains populating asx and β-type like turn conformations.
Proteins
Rybka K, Toal SE, Verbaro DJ, Mathieu D, Schwalbe H, Schweitzer-Stenner R PubMed
Jun 2013 Volume: 81 Issue: 6 Pages: 968-83

Disorder and order in unfolded and disordered peptides and proteins: a view derived from tripeptide conformational analysis. I. Tripeptides with long and predominantly hydrophobic side chains.
Proteins
Schweitzer-Stenner R, Hagarman A, Toal S, Mathieu D, Schwalbe H PubMed
Jun 2013 Volume: 81 Issue: 6 Pages: 955-67

Characterization of the ground state dynamics of proteorhodopsin by NMR and optical spectroscopies.
Journal of biomolecular NMR
Stehle J, Scholz F, Löhr F, Reckel S, Roos C, Blum M, Braun M, Glaubitz C, Dötsch V, Wachtveitl J, Schwalbe H PubMed
Dec 2012 Volume: 54 Issue: 4 Pages: 401-13

NMR studies of HAR1 RNA secondary structures reveal conformational dynamics in the human RNA.
Chembiochem : a European journal of chemical biology
Ziegeler M, Cevec M, Richter C, Schwalbe H PubMed
Sep 2012 Volume: 13 Issue: 14 Pages: 2100-12

Protein NMR spectroscopy: Hydrogen bonds under pressure.
Nature chemistry
Nielsen G, Schwalbe H PubMed
Sep 2012 Volume: 4 Issue: 9 Pages: 693-5

The apo-structure of the low molecular weight protein-tyrosine phosphatase A (MptpA) from Mycobacterium tuberculosis allows for better target-specific drug development.
The Journal of biological chemistry
Stehle T, Sreeramulu S, Löhr F, Richter C, Saxena K, Jonker HR, Schwalbe H PubMed
Oct 2012 Volume: 287 Issue: 41 Pages: 34569-82

Atomic-level structure characterization of an ultrafast folding mini-protein denatured state.
PloS one
Rogne P, Ozdowy P, Richter C, Saxena K, Schwalbe H, Kuhn LT PubMed
2012 Volume: 7 Issue: 7 Pages: e41301

Recombinant expression and purification of human TATA binding protein using a chimeric fusion.
Protein expression and purification
Silvers R, Saxena K, Kudlinzki D, Schwalbe H PubMed
Sep 2012 Volume: 85 Issue: 1 Pages: 142-7

¹H, ¹³C and ¹⁵N assignment of D2 domain of human fibroblast growth factor receptor 4.
Biomolecular NMR assignments
Elshorst B, Saxena K, Schieborr U, Schwalbe H PubMed
Oct 2013 Volume: 7 Issue: 2 Pages: 179-82

Individual basepair stability of DNA and RNA studied by NMR-detected solvent exchange.
Biophysical journal
Steinert HS, Rinnenthal J, Schwalbe H PubMed
Jun 2012 Volume: 102 Issue: 11 Pages: 2564-74

Ionized trilysine: a model system for understanding the nonrandom structure of poly-L-lysine and lysine-containing motifs in proteins.
The journal of physical chemistry. B
Verbaro DJ, Mathieu D, Toal SE, Schwalbe H, Schweitzer-Stenner R PubMed
Jul 2012 Volume: 116 Issue: 28 Pages: 8084-94

Mechanisms for differentiation between cognate and near-cognate ligands by purine riboswitches.
RNA biology
Wacker A, Buck J, Richter C, Schwalbe H, Wöhnert J PubMed
May 2012 Volume: 9 Issue: 5 Pages: 672-80

Spectroscopic, molecular modeling, and NMR-spectroscopic investigation of the binding mode of the natural alkaloids berberine and sanguinarine to human telomeric G-quadruplex DNA.
ACS chemical biology
Bessi I, Bazzicalupi C, Richter C, Jonker HR, Saxena K, Sissi C, Chioccioli M, Bianco S, Bilia AR, Schwalbe H, Gratteri P PubMed
Jun 2012 Volume: 7 Issue: 6 Pages: 1109-19

Tracing the tail of ubiquinone in mitochondrial complex I.
Biochimica et biophysica acta
Angerer H, Nasiri HR, Niedergesäß V, Kerscher S, Schwalbe H, Brandt U PubMed
Oct 2012 Volume: 1817 Issue: 10 Pages: 1776-84

Disentangling the coil: modulation of conformational and dynamic properties by site-directed mutation in the non-native state of hen egg white lysozyme.
Biochemistry
Sziegat F, Silvers R, Hähnke M, Jensen MR, Blackledge M, Wirmer-Bartoschek J, Schwalbe H PubMed
Apr 2012 Volume: 51 Issue: 16 Pages: 3361-72

Modulation of structure and dynamics by disulfide bond formation in unfolded states.
Journal of the American Chemical Society
Silvers R, Sziegat F, Tachibana H, Segawa S, Whittaker S, Günther UL, Gabel F, Huang JR, Blackledge M, Wirmer-Bartoschek J, Schwalbe H PubMed
Apr 2012 Volume: 134 Issue: 15 Pages: 6846-54

The nature of hydrogen bonds in cytidine···H+···cytidine DNA base pairs.
Angewandte Chemie (International ed. in English)
Lieblein AL, Krämer M, Dreuw A, Fürtig B, Schwalbe H PubMed
Apr 2012 Volume: 51 Issue: 17 Pages: 4067-70

Blind testing of routine, fully automated determination of protein structures from NMR data.
Structure (London, England : 1993)
Rosato A, Aramini JM, Arrowsmith C, Bagaria A, Baker D, Cavalli A, Doreleijers JF, Eletsky A, Giachetti A, Guerry P, Gutmanas A, Güntert P, He Y, Herrmann T, Huang YJ, Jaravine V, Jonker HR, Kennedy MA, Lange OF, Liu G, Malliavin TE, Mani R, Mao B, Montelione GT, Nilges M, Rossi P, van der Schot G, Schwalbe H, Szyperski TA, Vendruscolo M, Vernon R, Vranken WF, Vries Sd, Vuister GW, Wu B, Yang Y, Bonvin AM PubMed
Feb 2012 Volume: 20 Issue: 2 Pages: 227-36

Functional dynamics of RNA ribozymes studied by NMR spectroscopy.
Methods in molecular biology (Clifton, N.J.)
Fürtig B, Buck J, Richter C, Schwalbe H PubMed
2012 Volume: 848 Issue: Pages: 185-99

Isotope labeling in mammalian cells.
Methods in molecular biology (Clifton, N.J.)
Dutta A, Saxena K, Schwalbe H, Klein-Seetharaman J PubMed
2012 Volume: 831 Issue: Pages: 55-69

Isotope labeling in insect cells.
Methods in molecular biology (Clifton, N.J.)
Saxena K, Dutta A, Klein-Seetharaman J, Schwalbe H PubMed
2012 Volume: 831 Issue: Pages: 37-54

Time-resolved NMR spectroscopic studies of DNA i-motif folding reveal kinetic partitioning.
Angewandte Chemie (International ed. in English)
Lieblein AL, Buck J, Schlepckow K, Fürtig B, Schwalbe H PubMed
Jan 2012 Volume: 51 Issue: 1 Pages: 250-3

Solution NMR structure of proteorhodopsin.
Angewandte Chemie (International ed. in English)
Reckel S, Gottstein D, Stehle J, Löhr F, Verhoefen MK, Takeda M, Silvers R, Kainosho M, Glaubitz C, Wachtveitl J, Bernhard F, Schwalbe H, Güntert P, Dötsch V PubMed
Dec 2011 Volume: 50 Issue: 50 Pages: 11942-6

NMR spectroscopic investigations of the activated p38α mitogen-activated protein kinase.
Chembiochem : a European journal of chemical biology
Nielsen G, Schwalbe H PubMed
Nov 2011 Volume: 12 Issue: 17 Pages: 2599-607

Mapping the landscape of RNA dynamics with NMR spectroscopy.
Accounts of chemical research
Rinnenthal J, Buck J, Ferner J, Wacker A, Fürtig B, Schwalbe H PubMed
Dec 2011 Volume: 44 Issue: 12 Pages: 1292-301

Influence of ground-state structure and Mg2+ binding on folding kinetics of the guanine-sensing riboswitch aptamer domain.
Nucleic acids research
Buck J, Wacker A, Warkentin E, Wöhnert J, Wirmer-Bartoschek J, Schwalbe H PubMed
Dec 2011 Volume: 39 Issue: 22 Pages: 9768-78

Modulation of the stability of the Salmonella fourU-type RNA thermometer.
Nucleic acids research
Rinnenthal J, Klinkert B, Narberhaus F, Schwalbe H PubMed
Oct 2011 Volume: 39 Issue: 18 Pages: 8258-70

Structure and dynamics of the deoxyguanosine-sensing riboswitch studied by NMR-spectroscopy.
Nucleic acids research
Wacker A, Buck J, Mathieu D, Richter C, Wöhnert J, Schwalbe H PubMed
Aug 2011 Volume: 39 Issue: 15 Pages: 6802-12

Characteristics of human lysozyme and its disease-related mutants in their unfolded states.
Angewandte Chemie (International ed. in English)
Sziegat F, Wirmer-Bartoschek J, Schwalbe H PubMed
Jun 2011 Volume: 50 Issue: 24 Pages: 5514-8

Determination of the conformation of the 2'OH group in RNA by NMR spectroscopy and DFT calculations.
Angewandte Chemie (International ed. in English)
Nozinovic S, Gupta P, Fürtig B, Richter C, Tüllmann S, Duchardt-Ferner E, Holthausen MC, Schwalbe H PubMed
May 2011 Volume: 50 Issue: 23 Pages: 5397-400

Amino acids with hydrogen-bonding side chains have an intrinsic tendency to sample various turn conformations in aqueous solution.
Chemistry (Weinheim an der Bergstrasse, Germany)
Hagarman A, Mathieu D, Toal S, Measey TJ, Schwalbe H, Schweitzer-Stenner R PubMed
Jun 2011 Volume: 17 Issue: 24 Pages: 6789-97

Investigation at residue level of the early steps during the assembly of two proteins into supramolecular objects.
Biomacromolecules
Salvatore DB, Duraffourg N, Favier A, Persson BA, Lund M, Delage MM, Silvers R, Schwalbe H, Croguennec T, Bouhallab S, Forge V PubMed
Jun 2011 Volume: 12 Issue: 6 Pages: 2200-10

NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site.
Angewandte Chemie (International ed. in English)
Jonker HR, Baumann S, Wolf A, Schoof S, Hiller F, Schulte KW, Kirschner KN, Schwalbe H, Arndt HD PubMed
Mar 2011 Volume: 50 Issue: 14 Pages: 3308-12

Double take on Piwi protein/piRNA complex structure.
Structure (London, England : 1993)
Schwalbe H PubMed
Feb 2011 Volume: 19 Issue: 2 Pages: 141-2

NMR studies of DOXP reductoisomerase and its inhibitor complex.
Chembiochem : a European journal of chemical biology
Englert NE, Richter C, Wiesner J, Hintz M, Jomaa H, Schwalbe H PubMed
Feb 2011 Volume: 12 Issue: 3 Pages: 468-76

Engineering encodable lanthanide-binding tags into loop regions of proteins.
Journal of the American Chemical Society
Barthelmes K, Reynolds AM, Peisach E, Jonker HR, DeNunzio NJ, Allen KN, Imperiali B, Schwalbe H PubMed
Feb 2011 Volume: 133 Issue: 4 Pages: 808-19

Translation on demand by a simple RNA-based thermosensor.
Nucleic acids research
Kortmann J, Sczodrok S, Rinnenthal J, Schwalbe H, Narberhaus F PubMed
Apr 2011 Volume: 39 Issue: 7 Pages: 2855-68

Optimization of transversal relaxation of nitroxides for pulsed electron-electron double resonance spectroscopy in phospholipid membranes.
The journal of physical chemistry. B
Dastvan R, Bode BE, Karuppiah MP, Marko A, Lyubenova S, Schwalbe H, Prisner TF PubMed
Oct 2010 Volume: 114 Issue: 42 Pages: 13507-16

Folding kinetics for the conformational switch between alternative RNA structures.
The journal of physical chemistry. B
Cao S, Fürtig B, Schwalbe H, Chen SJ PubMed
Oct 2010 Volume: 114 Issue: 42 Pages: 13609-15

Quantitative 2D and 3D Gamma-HCP experiments for the determination of the angles alpha and zeta in the phosphodiester backbone of oligonucleotides.
Journal of the American Chemical Society
Nozinovic S, Richter C, Rinnenthal J, Fürtig B, Duchardt-Ferner E, Weigand JE, Schwalbe H PubMed
Aug 2010 Volume: 132 Issue: 30 Pages: 10318-29

The molecular mechanism of spider-silk formation.
Angewandte Chemie (International ed. in English)
Silvers R, Buhr F, Schwalbe H PubMed
Jul 2010 Volume: 49 Issue: 32 Pages: 5410-2

Influence of heparin mimetics on assembly of the FGF.FGFR4 signaling complex.
The Journal of biological chemistry
Saxena K, Schieborr U, Anderka O, Duchardt-Ferner E, Elshorst B, Gande SL, Janzon J, Kudlinzki D, Sreeramulu S, Dreyer MK, Wendt KU, Herbert C, Duchaussoy P, Bianciotto M, Driguez PA, Lassalle G, Savi P, Mohammadi M, Bono F, Schwalbe H PubMed
Aug 2010 Volume: 285 Issue: 34 Pages: 26628-40

13C-direct detected NMR experiments for the sequential J-based resonance assignment of RNA oligonucleotides.
Journal of biomolecular NMR
Richter C, Kovacs H, Buck J, Wacker A, Fürtig B, Bermel W, Schwalbe H PubMed
Aug 2010 Volume: 47 Issue: 4 Pages: 259-69

The unfolded state of the murine prion protein and properties of single-point mutants related to human prion diseases.
Journal of molecular biology
Gerum C, Schlepckow K, Schwalbe H PubMed
Aug 2010 Volume: 401 Issue: 1 Pages: 7-12

Probing mechanism and transition state of RNA refolding.
ACS chemical biology
Fürtig B, Wenter P, Pitsch S, Schwalbe H PubMed
Aug 2010 Volume: 5 Issue: 8 Pages: 753-65

High-resolution studies of uniformly 13C,15N-labeled RNA by solid-state NMR spectroscopy.
Angewandte Chemie (International ed. in English)
Cherepanov AV, Glaubitz C, Schwalbe H PubMed
Jun 2010 Volume: 49 Issue: 28 Pages: 4747-50

Prion protein amyloid formation involves structural rearrangements in the C-terminal domain.
Chembiochem : a European journal of chemical biology
Kumar J, Sreeramulu S, Schmidt TL, Richter C, Vonck J, Heckel A, Glaubitz C, Schwalbe H PubMed
Jun 2010 Volume: 11 Issue: 9 Pages: 1208-13

Thermodynamics: the world is flat.
Nature chemical biology
Schwalbe H, Rinnenthal J PubMed
May 2010 Volume: 6 Issue: 5 Pages: 312-3

Direct observation of the temperature-induced melting process of the Salmonella fourU RNA thermometer at base-pair resolution.
Nucleic acids research
Rinnenthal J, Klinkert B, Narberhaus F, Schwalbe H PubMed
Jun 2010 Volume: 38 Issue: 11 Pages: 3834-47

Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain.
Nucleic acids research
Buck J, Noeske J, Wöhnert J, Schwalbe H PubMed
Jul 2010 Volume: 38 Issue: 12 Pages: 4143-53

Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR.
Molecular and cellular biology
Doller A, Schlepckow K, Schwalbe H, Pfeilschifter J, Eberhardt W PubMed
Mar 2010 Volume: 30 Issue: 6 Pages: 1397-410

The HN(COCA)HAHB NMR experiment for the stereospecific assignment of Hbeta-protons in non-native states of proteins.
Journal of the American Chemical Society
Hähnke MJ, Richter C, Heinicke F, Schwalbe H PubMed
Jan 2010 Volume: 132 Issue: 3 Pages: 918-9

Intrinsic propensities of amino acid residues in GxG peptides inferred from amide I' band profiles and NMR scalar coupling constants.
Journal of the American Chemical Society
Hagarman A, Measey TJ, Mathieu D, Schwalbe H, Schweitzer-Stenner R PubMed
Jan 2010 Volume: 132 Issue: 2 Pages: 540-51

High-resolution NMR structure of an RNA model system: the 14-mer cUUCGg tetraloop hairpin RNA.
Nucleic acids research
Nozinovic S, Fürtig B, Jonker HR, Richter C, Schwalbe H PubMed
Jan 2010 Volume: 38 Issue: 2 Pages: 683-94

Unfolded-state structure and dynamics influence the fibril formation of human prion protein.
Angewandte Chemie (International ed. in English)
Gerum C, Silvers R, Wirmer-Bartoschek J, Schwalbe H PubMed
2009 Volume: 48 Issue: 50 Pages: 9452-6

Evaluation of parameters critical for observing nucleic acids inside living Xenopus laevis oocytes by in-cell NMR spectroscopy.
Journal of the American Chemical Society
Hänsel R, Foldynová-Trantírková S, Löhr F, Buck J, Bongartz E, Bamberg E, Schwalbe H, Dötsch V, Trantírek L PubMed
Nov 2009 Volume: 131 Issue: 43 Pages: 15761-8

RNA phosphodiester backbone dynamics of a perdeuterated cUUCGg tetraloop RNA from phosphorus-31 NMR relaxation analysis.
Journal of biomolecular NMR
Rinnenthal J, Richter C, Nozinovic S, Fürtig B, Lopez JJ, Glaubitz C, Schwalbe H PubMed
Sep 2009 Volume: 45 Issue: 1-2 Pages: 143-55

NMR spectroscopic characterization of the adenine-dependent hairpin ribozyme.
Chembiochem : a European journal of chemical biology
Buck J, Li YL, Richter C, Vergne J, Maurel MC, Schwalbe H PubMed
Aug 2009 Volume: 10 Issue: 12 Pages: 2100-10

Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol.
Angewandte Chemie (International ed. in English)
Sreeramulu S, Gande SL, Göbel M, Schwalbe H PubMed
2009 Volume: 48 Issue: 32 Pages: 5853-5

Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.
Chembiochem : a European journal of chemical biology
Ferner J, Suhartono M, Breitung S, Jonker HR, Hennig M, Wöhnert J, Göbel M, Schwalbe H PubMed
Jun 2009 Volume: 10 Issue: 9 Pages: 1490-4

HNHC: a triple resonance experiment for correlating the H2, N1(N3) and C2 resonances in adenine nucleobases of 13C-, 15N-labeled RNA oligonucleotides.
Journal of biomolecular NMR
Rinnenthal J, Schwalbe H PubMed
Jun 2009 Volume: 44 Issue: 2 Pages: 101-5

Time-resolved NMR spectroscopy: ligand-induced refolding of riboswitches.
Methods in molecular biology (Clifton, N.J.)
Buck J, Fürtig B, Noeske J, Wöhnert J, Schwalbe H PubMed
2009 Volume: 540 Issue: Pages: 161-71

Metal-induced folding of Diels-Alderase ribozymes studied by static and time-resolved NMR spectroscopy.
Journal of the American Chemical Society
Manoharan V, Fürtig B, Jäschke A, Schwalbe H PubMed
May 2009 Volume: 131 Issue: 17 Pages: 6261-70

Mutations in gp120 contribute to the resistance of human immunodeficiency virus type 1 to membrane-anchored C-peptide maC46.
Journal of virology
Hermann FG, Egerer L, Brauer F, Gerum C, Schwalbe H, Dietrich U, von Laer D PubMed
May 2009 Volume: 83 Issue: 10 Pages: 4844-53

The correlation of cathodic peak potentials of vitamin K(3) derivatives and their calculated electron affinities. The role of hydrogen bonding and conformational changes.
Biochimica et biophysica acta
Nasiri HR, Panisch R, Madej MG, Bats JW, Lancaster CR, Schwalbe H PubMed
Jun 2009 Volume: 1787 Issue: 6 Pages: 601-8

Perspectives on NMR in drug discovery: a technique comes of age.
Nature reviews. Drug discovery
Pellecchia M, Bertini I, Cowburn D, Dalvit C, Giralt E, Jahnke W, James TL, Homans SW, Kessler H, Luchinat C, Meyer B, Oschkinat H, Peng J, Schwalbe H, Siegal G PubMed
Sep 2008 Volume: 7 Issue: 9 Pages: 738-45

Production, characterization and determination of the real catalytic properties of the putative 'succinate dehydrogenase' from Wolinella succinogenes.
Molecular microbiology
Juhnke HD, Hiltscher H, Nasiri HR, Schwalbe H, Lancaster CR PubMed
Mar 2009 Volume: 71 Issue: 5 Pages: 1088-101

Model development for the viral Kcv potassium channel.
Biophysical journal
Tayefeh S, Kloss T, Kreim M, Gebhardt M, Baumeister D, Hertel B, Richter C, Schwalbe H, Moroni A, Thiel G, Kast SM PubMed
Jan 2009 Volume: 96 Issue: 2 Pages: 485-98

The state of the art of chemical biology.
Chembiochem : a European journal of chemical biology
Altmann KH, Buchner J, Kessler H, Diederich F, Kräutler B, Lippard S, Liskamp R, Müller K, Nolan EM, Samori B, Schneider G, Schreiber SL, Schwalbe H, Toniolo C, van Boeckel CA, Waldmann H, Walsh CT PubMed
Jan 2009 Volume: 10 Issue: 1 Pages: 16-29

The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy.
The Journal of biological chemistry
Sreeramulu S, Jonker HR, Langer T, Richter C, Lancaster CR, Schwalbe H PubMed
Feb 2009 Volume: 284 Issue: 6 Pages: 3885-96

The high resolution NMR structure of parvulustat (Z-2685) from Streptomyces parvulus FH-1641: comparison with tendamistat from Streptomyces tendae 4158.
Chembiochem : a European journal of chemical biology
Rehm S, Han S, Hassani I, Sokocevic A, Jonker HR, Engels JW, Schwalbe H PubMed
Jan 2009 Volume: 10 Issue: 1 Pages: 119-27

Theoretical study of the human bradykinin-bradykinin B2 receptor complex.
Chembiochem : a European journal of chemical biology
Gieldon A, Lopez JJ, Glaubitz C, Schwalbe H PubMed
Oct 2008 Volume: 9 Issue: 15 Pages: 2487-97

Synthesis and biological properties of cylindramide derivatives: evidence for calcium-dependent cytotoxicity of tetramic acid lactams.
Chembiochem : a European journal of chemical biology
Cramer N, Helbig S, Baro A, Laschat S, Diestel R, Sasse F, Mathieu D, Richter C, Kummerlöwe G, Luy B, Schwalbe H PubMed
Oct 2008 Volume: 9 Issue: 15 Pages: 2474-86

Influence of a joining helix on the BLUF domain of the YcgF photoreceptor from Escherichia coli.
Chembiochem : a European journal of chemical biology
Schroeder C, Werner K, Otten H, Krätzig S, Schwalbe H, Essen LO PubMed
Oct 2008 Volume: 9 Issue: 15 Pages: 2463-73

Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis.
Angewandte Chemie (International ed. in English)
Nören-Müller A, Wilk W, Saxena K, Schwalbe H, Kaiser M, Waldmann H PubMed
2008 Volume: 47 Issue: 32 Pages: 5973-7

Starting structure dependence of NMR order parameters derived from MD simulations: implications for judging force-field quality.
Biophysical journal
Koller AN, Schwalbe H, Gohlke H PubMed
Jul 2008 Volume: 95 Issue: 1 Pages: L04-6

NMR-spectroscopic characterization of phosphodiester bond cleavage catalyzed by the minimal hammerhead ribozyme.
RNA biology
Fürtig B, Richter C, Schell P, Wenter P, Pitsch S, Schwalbe H PubMed
2008 Volume: 5 Issue: 1 Pages: 41-8

Conserved folding pathways of alpha-lactalbumin and lysozyme revealed by kinetic CD, fluorescence, NMR, and interrupted refolding experiments.
Journal of molecular biology
Schlepckow K, Wirmer J, Bachmann A, Kiefhaber T, Schwalbe H PubMed
May 2008 Volume: 378 Issue: 3 Pages: 686-98

NMR and MD studies of the temperature-dependent dynamics of RNA YNMG-tetraloops.
Nucleic acids research
Ferner J, Villa A, Duchardt E, Widjajakusuma E, Wöhnert J, Stock G, Schwalbe H PubMed
Apr 2008 Volume: 36 Issue: 6 Pages: 1928-40

The structure of the neuropeptide bradykinin bound to the human G-protein coupled receptor bradykinin B2 as determined by solid-state NMR spectroscopy.
Angewandte Chemie (International ed. in English)
Lopez JJ, Shukla AK, Reinhart C, Schwalbe H, Michel H, Glaubitz C PubMed
2008 Volume: 47 Issue: 9 Pages: 1668-71

Inhibition of HIV-1 by a peptide ligand of the genomic RNA packaging signal Psi.
ChemMedChem
Dietz J, Koch J, Kaur A, Raja C, Stein S, Grez M, Pustowka A, Mensch S, Ferner J, Möller L, Bannert N, Tampé R, Divita G, Mély Y, Schwalbe H, Dietrich U PubMed
May 2008 Volume: 3 Issue: 5 Pages: 749-55

Conformational dynamics of bistable RNAs studied by time-resolved NMR spectroscopy.
Journal of the American Chemical Society
Fürtig B, Wenter P, Reymond L, Richter C, Pitsch S, Schwalbe H PubMed
Dec 2007 Volume: 129 Issue: 51 Pages: 16222-9

Isotope labeling of mammalian GPCRs in HEK293 cells and characterization of the C-terminus of bovine rhodopsin by high resolution liquid NMR spectroscopy.
Journal of biomolecular NMR
Werner K, Richter C, Klein-Seetharaman J, Schwalbe H PubMed
Jan 2008 Volume: 40 Issue: 1 Pages: 49-53

Time-resolved NMR methods resolving ligand-induced RNA folding at atomic resolution.
Proceedings of the National Academy of Sciences of the United States of America
Buck J, Fürtig B, Noeske J, Wöhnert J, Schwalbe H PubMed
Oct 2007 Volume: 104 Issue: 40 Pages: 15699-704

Tripeptides from synthetic amino acids block the Tat-TAR association and slow down HIV spread in cell cultures.
Chembiochem : a European journal of chemical biology
Ludwig V, Krebs A, Stoll M, Dietrich U, Ferner J, Schwalbe H, Scheffer U, Dürner G, Göbel MW PubMed
Oct 2007 Volume: 8 Issue: 15 Pages: 1850-6

Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain.
Nucleic acids research
Noeske J, Schwalbe H, Wöhnert J PubMed
2007 Volume: 35 Issue: 15 Pages: 5262-73

Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).
Chemistry, an Asian journal
Corrêa IR, Nören-Müller A, Ambrosi HD, Jakupovic S, Saxena K, Schwalbe H, Kaiser M, Waldmann H PubMed
Sep 2007 Volume: 2 Issue: 9 Pages: 1109-26

Quantitative gamma-HCNCH: determination of the glycosidic torsion angle chi in RNA oligonucleotides from the analysis of CH dipolar cross-correlated relaxation by solution NMR spectroscopy.
Journal of biomolecular NMR
Rinnenthal J, Richter C, Ferner J, Duchardt E, Schwalbe H PubMed
Sep 2007 Volume: 39 Issue: 1 Pages: 17-29

Theoretical framework for NMR residual dipolar couplings in unfolded proteins.
Journal of biomolecular NMR
Obolensky OI, Schlepckow K, Schwalbe H, Solov'yov AV PubMed
Sep 2007 Volume: 39 Issue: 1 Pages: 1-16

Time-resolved NMR studies of RNA folding.
Biopolymers
Fürtig B, Buck J, Manoharan V, Bermel W, Jäschke A, Wenter P, Pitsch S, Schwalbe H PubMed
Volume: 86 Issue: 5-6 Pages: 360-83

Comparison of the NMR spectroscopy solution structures of pyranosyl-rNA and its nucleo-delta-peptide analogue.
Chembiochem : a European journal of chemical biology
Ilin S, Schlönvogt I, Ebert MO, Jaun B, Schwalbe H PubMed
Jan 2002 Volume: 3 Issue: 1 Pages: 93-9

Double-lanthanide-binding tags for macromolecular crystallographic structure determination.
Journal of the American Chemical Society
Silvaggi NR, Martin LJ, Schwalbe H, Imperiali B, Allen KN PubMed
Jun 2007 Volume: 129 Issue: 22 Pages: 7114-20

Double-lanthanide-binding tags: design, photophysical properties, and NMR applications.
Journal of the American Chemical Society
Martin LJ, Hähnke MJ, Nitz M, Wöhnert J, Silvaggi NR, Allen KN, Schwalbe H, Imperiali B PubMed
Jun 2007 Volume: 129 Issue: 22 Pages: 7106-13

Structure induction of the T-cell receptor zeta-chain upon lipid binding investigated by NMR spectroscopy.
Chembiochem : a European journal of chemical biology
Duchardt E, Sigalov AB, Aivazian D, Stern LJ, Schwalbe H PubMed
May 2007 Volume: 8 Issue: 7 Pages: 820-7

Combined solid state and solution NMR studies of alpha,epsilon-15N labeled bovine rhodopsin.
Journal of biomolecular NMR
Werner K, Lehner I, Dhiman HK, Richter C, Glaubitz C, Schwalbe H, Klein-Seetharaman J, Khorana HG PubMed
Apr 2007 Volume: 37 Issue: 4 Pages: 303-12

Structure and dynamics of the homologous series of alanine peptides: a joint molecular dynamics/NMR study.
Journal of the American Chemical Society
Graf J, Nguyen PH, Stock G, Schwalbe H PubMed
Feb 2007 Volume: 129 Issue: 5 Pages: 1179-89

Structures of RNA switches: insight into molecular recognition and tertiary structure.
Angewandte Chemie (International ed. in English)
Schwalbe H, Buck J, Fürtig B, Noeske J, Wöhnert J PubMed
2007 Volume: 46 Issue: 8 Pages: 1212-9

Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch.
Nucleic acids research
Noeske J, Buck J, Fürtig B, Nasiri HR, Schwalbe H, Wöhnert J PubMed
2007 Volume: 35 Issue: 2 Pages: 572-83

L11 domain rearrangement upon binding to RNA and thiostrepton studied by NMR spectroscopy.
Nucleic acids research
Jonker HR, Ilin S, Grimm SK, Wöhnert J, Schwalbe H PubMed
2007 Volume: 35 Issue: 2 Pages: 441-54

Experimental evidence for proton motive force-dependent catalysis by the diheme-containing succinate:menaquinone oxidoreductase from the Gram-positive bacterium Bacillus licheniformis.
Biochemistry
Madej MG, Nasiri HR, Hilgendorff NS, Schwalbe H, Unden G, Lancaster CR PubMed
Dec 2006 Volume: 45 Issue: 50 Pages: 15049-55

2-Hydroxy-3-(3-oxobutyl)naphthalene-1,4-dione.
Acta crystallographica. Section C, Crystal structure communications
Nasiri HR, Madej MG, Lancaster CR, Schwalbe H, Bolte M PubMed
Dec 2006 Volume: 62 Issue: Pt 12 Pages: o671-3

Evidence for transmembrane proton transfer in a dihaem-containing membrane protein complex.
The EMBO journal
Madej MG, Nasiri HR, Hilgendorff NS, Schwalbe H, Lancaster CR PubMed
Oct 2006 Volume: 25 Issue: 20 Pages: 4963-70

Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity.
Journal of medicinal chemistry
Müller D, Krick A, Kehraus S, Mehner C, Hart M, Küpper FC, Saxena K, Prinz H, Schwalbe H, Janning P, Waldmann H, König GM PubMed
Aug 2006 Volume: 49 Issue: 16 Pages: 4871-8

Phosphate-group recognition by the aptamer domain of the thiamine pyrophosphate sensing riboswitch.
Chembiochem : a European journal of chemical biology
Noeske J, Richter C, Stirnal E, Schwalbe H, Wöhnert J PubMed
Sep 2006 Volume: 7 Issue: 9 Pages: 1451-6

A tryptophan-rich hexapeptide inhibits nucleic acid destabilization chaperoned by the HIV-1 nucleocapsid protein.
Biochemistry
Raja C, Ferner J, Dietrich U, Avilov S, Ficheux D, Darlix JL, de Rocquigny H, Schwalbe H, Mély Y PubMed
Aug 2006 Volume: 45 Issue: 30 Pages: 9254-65

Motional properties of unfolded ubiquitin: a model for a random coil protein.
Journal of biomolecular NMR
Wirmer J, Peti W, Schwalbe H PubMed
Jul 2006 Volume: 35 Issue: 3 Pages: 175-86

NMR backbone assignment of the N-terminal domain of human HSP90.
Journal of biomolecular NMR
Jacobs DM, Langer T, Elshorst B, Saxena K, Fiebig KM, Vogtherr M, Schwalbe H PubMed
2006 Volume: 36 Suppl 1 Issue: Pages: 52

Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis.
Proceedings of the National Academy of Sciences of the United States of America
Nören-Müller A, Reis-Corrêa I, Prinz H, Rosenbaum C, Saxena K, Schwalbe HJ, Vestweber D, Cagna G, Schunk S, Schwarz O, Schiewe H, Waldmann H PubMed
Jul 2006 Volume: 103 Issue: 28 Pages: 10606-11

Characterization of the unfolded state of bovine alpha-lactalbumin and comparison with unfolded states of homologous proteins.
Protein science : a publication of the Protein Society
Wirmer J, Berk H, Ugolini R, Redfield C, Schwalbe H PubMed
Jun 2006 Volume: 15 Issue: 6 Pages: 1397-407

Biomolecular NMR: a chaperone to drug discovery.
Current opinion in chemical biology
Betz M, Saxena K, Schwalbe H PubMed
Jun 2006 Volume: 10 Issue: 3 Pages: 219-25

NMR analysis of a Tau phosphorylation pattern.
Journal of the American Chemical Society
Landrieu I, Lacosse L, Leroy A, Wieruszeski JM, Trivelli X, Sillen A, Sibille N, Schwalbe H, Saxena K, Langer T, Lippens G PubMed
Mar 2006 Volume: 128 Issue: 11 Pages: 3575-83

Photo-CIDNP reveals differences in compaction of non-native states of lysozyme.
Journal of the American Chemical Society
Schlörb C, Mensch S, Richter C, Schwalbe H PubMed
Feb 2006 Volume: 128 Issue: 6 Pages: 1802-3

A caged uridine for the selective preparation of an RNA fold and determination of its refolding kinetics by real-time NMR.
Chembiochem : a European journal of chemical biology
Wenter P, Fürtig B, Hainard A, Schwalbe H, Pitsch S PubMed
Mar 2006 Volume: 7 Issue: 3 Pages: 417-20

Total synthesis and NMR investigations of cylindramide.
Chemistry (Weinheim an der Bergstrasse, Germany)
Cramer N, Buchweitz M, Laschat S, Frey W, Baro A, Mathieu D, Richter C, Schwalbe H PubMed
Mar 2006 Volume: 12 Issue: 9 Pages: 2488-503

Experimental support for the "E pathway hypothesis" of coupled transmembrane e- and H+ transfer in dihemic quinol:fumarate reductase.
Proceedings of the National Academy of Sciences of the United States of America
Lancaster CR, Sauer US, Gross R, Haas AH, Graf J, Schwalbe H, Mäntele W, Simon J, Madej MG PubMed
Dec 2005 Volume: 102 Issue: 52 Pages: 18860-5

NMR characterization of kinase p38 dynamics in free and ligand-bound forms.
Angewandte Chemie (International ed. in English)
Vogtherr M, Saxena K, Hoelder S, Grimme S, Betz M, Schieborr U, Pescatore B, Robin M, Delarbre L, Langer T, Wendt KU, Schwalbe H PubMed
Jan 2006 Volume: 45 Issue: 6 Pages: 993-7

Glutamic acid-rich proteins of rod photoreceptors are natively unfolded.
The Journal of biological chemistry
Batra-Safferling R, Abarca-Heidemann K, Körschen HG, Tziatzios C, Stoldt M, Budyak I, Willbold D, Schwalbe H, Klein-Seetharaman J, Kaupp UB PubMed
Jan 2006 Volume: 281 Issue: 3 Pages: 1449-60

Backbone NMR assignment of the low-molecular-weight protein tyrosine phosphatase (MPtpA) from Mycobacterium tuberculosis.
Journal of biomolecular NMR
Saxena K, Elshorst B, Berk H, Betz M, Grimme S, Langer T, Pescatore B, Schieborr U, Vogtherr M, Schwalbe H PubMed
Oct 2005 Volume: 33 Issue: 2 Pages: 136

Heterologous expression of hen egg white lysozyme and resonance assignment of tryptophan side chains in its non-native states.
Journal of biomolecular NMR
Schlörb C, Ackermann K, Richter C, Wirmer J, Schwalbe H PubMed
Oct 2005 Volume: 33 Issue: 2 Pages: 95-104

Backbone NMR assignment of the human E2 ubiquitin conjugating enzyme UbcH5alpha (F72K,F82S) double mutant.
Journal of biomolecular NMR
Saxena K, Jacobs DM, Vogtherr M, Grimme S, Elshort B, Pescatore B, Betz M, Schieborr U, Langer T, Schwalbe H, Fiebig K PubMed
Aug 2005 Volume: 32 Issue: 4 Pages: 338

Backbone NMR assignment of the C-terminal haemopexin-like domain (HPLD) of human matrix metalloproteinase MMP-13.
Journal of biomolecular NMR
Jacobs DM, Grimme S, Elshorst B, Pescatore B, Vogtherr M, Betz M, Schieborr U, Langer T, Saxena K, Schwalbe H, Fiebig K PubMed
Aug 2005 Volume: 32 Issue: 4 Pages: 337

Residue specific ribose and nucleobase dynamics of the cUUCGg RNA tetraloop motif by MNMR 13C relaxation.
Journal of biomolecular NMR
Duchardt E, Schwalbe H PubMed
Aug 2005 Volume: 32 Issue: 4 Pages: 295-308

Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach.
Chembiochem : a European journal of chemical biology
Manger M, Scheck M, Prinz H, von Kries JP, Langer T, Saxena K, Schwalbe H, Fürstner A, Rademann J, Waldmann H PubMed
Oct 2005 Volume: 6 Issue: 10 Pages: 1749-53

Structure and dynamics of an RNA tetraloop: a joint molecular dynamics and NMR study.
Structure (London, England : 1993)
Koplin J, Mu Y, Richter C, Schwalbe H, Stock G PubMed
Sep 2005 Volume: 13 Issue: 9 Pages: 1255-67

Characterisation of disulfide-bond dynamics in non-native states of lysozyme and its disulfide deletion mutants by NMR.
Chembiochem : a European journal of chemical biology
Collins ES, Wirmer J, Hirai K, Tachibana H, Segawa S, Dobson CM, Schwalbe H PubMed
Sep 2005 Volume: 6 Issue: 9 Pages: 1619-27

1H, 13C and 15N backbone resonance assignment of the Hsp90 binding domain of human Cdc37.
Journal of biomolecular NMR
Sreeramulu S, Kumar J, Richter C, Vogtherr M, Saxena K, Langer T, Schwalbe H PubMed
Jul 2005 Volume: 32 Issue: 3 Pages: 262

Domain reorientation and induced fit upon RNA binding: solution structure and dynamics of ribosomal protein L11 from Thermotoga maritima.
Chembiochem : a European journal of chemical biology
Ilin S, Hoskins A, Ohlenschläger O, Jonker HR, Schwalbe H, Wöhnert J PubMed
Sep 2005 Volume: 6 Issue: 9 Pages: 1611-8

NMR backbone assignment of the mitogen-activated protein (MAP) kinase p38.
Journal of biomolecular NMR
Vogtherr M, Saxena K, Grimme S, Betz M, Schieborr U, Pescatore B, Langer T, Schwalbe H PubMed
Jun 2005 Volume: 32 Issue: 2 Pages: 175

Folding and activity of cAMP-dependent protein kinase mutants.
FEBS letters
Langer T, Sreeramulu S, Vogtherr M, Elshorst B, Betz M, Schieborr U, Saxena K, Schwalbe H PubMed
Aug 2005 Volume: 579 Issue: 19 Pages: 4049-54

How much NMR data is required to determine a protein-ligand complex structure?
Chembiochem : a European journal of chemical biology
Schieborr U, Vogtherr M, Elshorst B, Betz M, Grimme S, Pescatore B, Langer T, Saxena K, Schwalbe H PubMed
Oct 2005 Volume: 6 Issue: 10 Pages: 1891-8

Kinetics of photoinduced RNA refolding by real-time NMR spectroscopy.
Angewandte Chemie (International ed. in English)
Wenter P, Fürtig B, Hainard A, Schwalbe H, Pitsch S PubMed
Apr 2005 Volume: 44 Issue: 17 Pages: 2600-3

NMR spectroscopic detection of protein protons and longitudinal relaxation rates between 0.01 and 50 MHz.
Angewandte Chemie (International ed. in English)
Bertini I, Gupta YK, Luchinat C, Parigi G, Schlörb C, Schwalbe H PubMed
Apr 2005 Volume: 44 Issue: 15 Pages: 2223-5

An intermolecular base triple as the basis of ligand specificity and affinity in the guanine- and adenine-sensing riboswitch RNAs.
Proceedings of the National Academy of Sciences of the United States of America
Noeske J, Richter C, Grundl MA, Nasiri HR, Schwalbe H, Wöhnert J PubMed
Feb 2005 Volume: 102 Issue: 5 Pages: 1372-7

Enantioselective total synthesis of cylindramide.
Angewandte Chemie (International ed. in English)
Cramer N, Laschat S, Baro A, Schwalbe H, Richter C PubMed
Jan 2005 Volume: 44 Issue: 5 Pages: 820-2

Modulation of compactness and long-range interactions of unfolded lysozyme by single point mutations.
Angewandte Chemie (International ed. in English)
Wirmer J, Schlörb C, Klein-Seetharaman J, Hirano R, Ueda T, Imoto T, Schwalbe H PubMed
Nov 2004 Volume: 43 Issue: 43 Pages: 5780-5

NMR backbone assignment of a protein kinase catalytic domain by a combination of several approaches: application to the catalytic subunit of cAMP-dependent protein kinase.
Chembiochem : a European journal of chemical biology
Langer T, Vogtherr M, Elshorst B, Betz M, Schieborr U, Saxena K, Schwalbe H PubMed
Nov 2004 Volume: 5 Issue: 11 Pages: 1508-16

Molecules as modulators: systems biology challenges chemistry.
Chembiochem : a European journal of chemical biology
Schwalbe H, Wess G PubMed
Oct 2004 Volume: 5 Issue: 10 Pages: 1311-3

Retroviral vectors pseudotyped with severe acute respiratory syndrome coronavirus S protein.
Journal of virology
Giroglou T, Cinatl J, Rabenau H, Drosten C, Schwalbe H, Doerr HW, von Laer D PubMed
Sep 2004 Volume: 78 Issue: 17 Pages: 9007-15

Differential dynamics in the G protein-coupled receptor rhodopsin revealed by solution NMR.
Proceedings of the National Academy of Sciences of the United States of America
Klein-Seetharaman J, Yanamala NV, Javeed F, Reeves PJ, Getmanova EV, Loewen MC, Schwalbe H, Khorana HG PubMed
Mar 2004 Volume: 101 Issue: 10 Pages: 3409-13

Determination of the glycosidic bond angle chi in RNA from cross-correlated relaxation of CH dipolar coupling and N chemical shift anisotropy.
Journal of the American Chemical Society
Duchardt E, Richter C, Ohlenschläger O, Görlach M, Wöhnert J, Schwalbe H PubMed
Feb 2004 Volume: 126 Issue: 7 Pages: 1962-70

New NMR experiments for RNA nucleobase resonance assignment and chemical shift analysis of an RNA UUCG tetraloop.
Journal of biomolecular NMR
Fürtig B, Richter C, Bermel W, Schwalbe H PubMed
Jan 2004 Volume: 28 Issue: 1 Pages: 69-79

NMR spectroscopic determination of the solution structure of a branched nucleic acid from residual dipolar couplings by using isotopically labeled nucleotides.
Angewandte Chemie (International ed. in English)
van Buuren BN, Schleucher J, Wittmann V, Griesinger C, Schwalbe H, Wijmenga SS PubMed
Jan 2004 Volume: 43 Issue: 2 Pages: 187-92

Protein alignment by a coexpressed lanthanide-binding tag for the measurement of residual dipolar couplings.
Journal of the American Chemical Society
Wöhnert J, Franz KJ, Nitz M, Imperiali B, Schwalbe H PubMed
Nov 2003 Volume: 125 Issue: 44 Pages: 13338-9

Identification of peptide ligands for target RNA structures derived from the HIV-1 packaging signal psi by screening phage-displayed peptide libraries.
Chembiochem : a European journal of chemical biology
Pustowka A, Dietz J, Ferner J, Baumann M, Landersz M, Königs C, Schwalbe H, Dietrich U PubMed
Oct 2003 Volume: 4 Issue: 10 Pages: 1093-7

NMR spectroscopy of RNA.
Chembiochem : a European journal of chemical biology
Fürtig B, Richter C, Wöhnert J, Schwalbe H PubMed
Oct 2003 Volume: 4 Issue: 10 Pages: 936-62

1H, 13C and 15N backbone resonance assignment of the integrin alpha2 I-domain.
Journal of biomolecular NMR
Elshorst B, Jacobs DM, Schwalbe H, Langer T PubMed
Oct 2003 Volume: 27 Issue: 2 Pages: 191-2

1H, 13C and 15N backbone resonance assignment of the VASP EVH1 domain.
Journal of biomolecular NMR
Vogtherr M, Grimme S, Pescatore B, Schwalbe H PubMed
Oct 2003 Volume: 27 Issue: 2 Pages: 189-90

Triple resonance experiments for the simultaneous correlation of H6/H5 and exchangeable protons of pyrimidine nucleotides in 13C,15N-labeled RNA applicable to larger RNA molecules.
Journal of biomolecular NMR
Wöhnert J, Görlach M, Schwalbe H PubMed
May 2003 Volume: 26 Issue: 1 Pages: 79-83

Gamma-HMBC: an NMR experiment for the conformational analysis of the o-glycosidic linkage in glycopeptides.
Angewandte Chemie (International ed. in English)
Ilin S, Bosques C, Turner C, Schwalbe H PubMed
Mar 2003 Volume: 42 Issue: 12 Pages: 1394-7

NMR assignment of the full-length ribosomal protein L11 from Thermotoga maritima.
Journal of biomolecular NMR
Ilin S, Hoskins A, Schwalbe H, Wöhnert J PubMed
Feb 2003 Volume: 25 Issue: 2 Pages: 163-4

Kurt Wüthrich, the ETH Zürich, and the development of NMR spectroscopy for the investigation of structure, dynamics, and folding of proteins.
Chembiochem : a European journal of chemical biology
Schwalbe H PubMed
Mar 2003 Volume: 4 Issue: 2-3 Pages: 135-42

Dissecting G-protein-coupled receptors: structure, function, and ligand interaction.
Chembiochem : a European journal of chemical biology
Schwalbe H, Wess G PubMed
Oct 2002 Volume: 3 Issue: 10 Pages: 915-9

Angular dependence of 1J(Ni,Calphai) and 2J(Ni,Calpha(i-1)) coupling constants measured in J-modulated HSQCs.
Journal of biomolecular NMR
Wirmer J, Schwalbe H PubMed
May 2002 Volume: 23 Issue: 1 Pages: 47-55

Long-range interactions within a nonnative protein.
Science (New York, N.Y.)
Klein-Seetharaman J, Oikawa M, Grimshaw SB, Wirmer J, Duchardt E, Ueda T, Imoto T, Smith LJ, Dobson CM, Schwalbe H PubMed
Mar 2002 Volume: 295 Issue: 5560 Pages: 1719-22

Millisecond Time Resolved Photo-CIDNP NMR Reveals a Non-Native Folding Intermediate on the Ion-Induced Refolding Pathway of Bovine α-Lactalbumin.
Angewandte Chemie (International ed. in English)
Wirmer J, Kühn T, Schwalbe H PubMed
Nov 2001 Volume: 40 Issue: 22 Pages: 4248-4251

Recent Advances in High-Resolution Solid-State NMR Spectroscopy We thank the Massachusetts Institute for Technology, the Karl Winnacker Foundation, and the NIH under the NCRR program (RR00995) for financial support. We thank Elke Duchardt for helping us prepare the figures.
Angewandte Chemie (International ed. in English)
Schwalbe H, Bielecki A PubMed
Jun 2001 Volume: 40 Issue: 11 Pages: 2045-2050

Recent Advances in High-Resolution Solid-State NMR Spectroscopy.
Angewandte Chemie (International ed. in English)
Schwalbe H, Bielecki A PubMed
Jun 2001 Volume: 40 Issue: 11 Pages: 2045-2050