Research Groups


Publications of Alexander Gottschalk (Results: 48)

RIC-3 phosphorylation enables dual regulation of excitation and inhibition of C. elegans muscle
Molecular Biology of the Cell
Safdie G, Liewald JF, Kagan S, Battat E, Gottschalk A, Treinin M. PubMed

Photoswitchable diacylglycerols enable optical control of protein kinase C
Nature Chemical Biology
Frank JA, Yushchenko DA, Hodson DJ, Lipstein N, Nagpal J, Rutter GA, Rhee J-S, Gottschalk A, Brose N, Schultz C, Trauner D. PubMed

Fast cAMP modulation of neurotransmission via neuropeptide signals and vesicle loading
Current Biology
Steuer Costa W, Yu S-c, Liewald JF, Gottschalk A. PubMed

Arrhythmogenic effects of mutated L-type Ca2+-channels on an optogenetically paced muscular pump in Caenorhabditis elegans  
Scientific Reports
Christina Schüler*, Elisabeth Fischer*, Lior Shaltiel, Wagner Steuer Costa & Alexander Gottschalk PubMed 

Microbial Rhodopsin Optogenetic Tools: Application for Analyses of Synaptic Transmission and of Neuronal Network Activity in Behavior
Springer Science+Business Media New York 2015
Glock C, Nagpal J, Gottschalk A. 

AzoCholine enables optical control of alpha 7 nicotinic acetylcholine receptors in neural networks. ACS Chem Neurosci.
ACS Chem Neurosci.
Damijonaitis A, Broichhagen J, Urushima T, Hüll K, Nagpal J, Laprell L, Schönberger M, Woodmansee DH, Rafiq A, Sumser MP, Kummer W, Gottschalk A, Trauner D. PubMed

Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp. 
Nature communications
Gao S, Nagpal J, Schneider M, Kozjak-Pavlovic J, Nagel G*, Gottschalk A*. PubMed 

A photosensitive degron enables acute light-induced protein degradation in the nervous system. 
Current Biology
Hermann A, Liewald JF, Gottschalk A. PubMed

High-throughput all-optical analysis of synaptic transmission and synaptic vesicle recycling in Caenorhabditis elegans. 
Sebastian Wabnig, Jana Fiona Liewald, Szi-chieh Yu, Alexander Gottschalk PubMed 

Synthetic retinal analogs modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools. 
Nature communications
AzimiHashemi N, Erbguth K, Vogt A, Riemensperger T, Rauch E, Woodmansee D, Nagpal J, Brauner M, Sheves M, Fiala A, Kattner L, Trauner D, Hegemann P, Gottschalk A, Liewald J PubMed

A consistent muscle activation strategy underlies crawling and swimming in Caenorhabditis elegans. 
Journal of the Royal Society, Interface
Butler VJ, Branicky R, Yemini E, Liewald JF, Gottschalk A, Kerr RA, Chklovskii DB, Schafer WR PubMed 

Optogenetische Analyse der Funktion neuronaler Netzwerke und der synaptischen Transmission in Caenorhabditis elegans. 
Gottschalk A PubMed 

Photoactivated adenylyl cyclases as optogenetic modulators of neuronal activity. 
Methods in molecular biology (Clifton, N.J.)
Costa WS, Liewald J, Gottschalk A PubMed 

Caenorhabditis elegans nicotinic acetylcholine receptors are required for nociception. 
Molecular and cellular neurosciences
Cohen E, Chatzigeorgiou M, Husson SJ, Steuer-Costa W, Gottschalk A, Schafer WR, Treinin M PubMed 

Sensory neuron fates are distinguished by a transcriptional switch that regulates dendrite branch stabilization. 
Smith CJ, O'Brien T, Chatzigeorgiou M, Spencer WC, Feingold-Link E, Husson SJ, Hori S, Mitani S, Gottschalk A, Schafer WR, Miller DM PubMed 

In vivo synaptic recovery following optogenetic hyperstimulation. 
Proceedings of the National Academy of Sciences of the United States of America
Kittelmann M, Liewald JF, Hegermann J, Schultheis C, Brauner M, Steuer Costa W, Wabnig S, Eimer S, Gottschalk A PubMed 

Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans. 
Optogenetics (de Gruyter; Dahlem Conference reports)
De Bono, M.; Schafer, W. R.; Gottschalk, A PubMed 

Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics. 
Frontiers in molecular neuroscience
Akerboom J, Carreras Calderón N, Tian L, Wabnig S, Prigge M, Tolö J, Gordus A, Orger MB, Severi KE, Macklin JJ, Patel R, Pulver SR, Wardill TJ, Fischer E, Schüler C, Chen TW, Sarkisyan KS, Marvin JS, Bargmann CI, Kim DS, Kügler S, Lagnado L, Hegemann P, Gottschalk A, Schreiter ER, Looger LL PubMed 

Optogenetic manipulation of neural activity in C. elegans: from synapse to circuits and behaviour. 
Biology of the cell / under the auspices of the European Cell Biology Organization
Husson SJ, Gottschalk A, Leifer AM PubMed 

Keeping track of worm trackers. 
WormBook : the online review of C. elegans biology
Husson SJ, Costa WS, Schmitt C, Gottschalk A PubMed 

RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans. 
Proceedings of the National Academy of Sciences of the United States of America
Sasidharan N, Sumakovic M, Hannemann M, Hegermann J, Liewald JF, Olendrowitz C, Koenig S, Grant BD, Rizzoli SO, Gottschalk A, Eimer S PubMed 

Bimodal activation of different neuron classes with the spectrally red-shifted channelrhodopsin chimera C1V1 in Caenorhabditis elegans. 
PloS one
Erbguth K, Prigge M, Schneider F, Hegemann P, Gottschalk A PubMed 

Specific expression of channelrhodopsin-2 in single neurons of Caenorhabditis elegans. 
PloS one
Schmitt C, Schultheis C, Pokala N, Husson SJ, Liewald JF, Bargmann CI, Gottschalk A PubMed 

Light-controlled tools. 
Angewandte Chemie (International ed. in English)
Brieke C, Rohrbach F, Gottschalk A, Mayer G, Heckel A PubMed 

Microbial light-activatable proton pumps as neuronal inhibitors to functionally dissect neuronal networks in C. elegans. 
PloS one
Husson SJ, Liewald JF, Schultheis C, Stirman JN, Lu H, Gottschalk A PubMed 

Optogenetic analysis of a nociceptor neuron and network reveals ion channels acting downstream of primary sensors. 
Current biology : CB
Husson SJ, Costa WS, Wabnig S, Stirman JN, Watson JD, Spencer WC, Akerboom J, Looger LL, Treinin M, Miller DM, Lu H, Gottschalk A PubMed 

A multispectral optical illumination system with precise spatiotemporal control for the manipulation of optogenetic reagents. 
Nature protocols
Stirman JN, Crane MM, Husson SJ, Gottschalk A, Lu H PubMed 

Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin. 
Proceedings of the National Academy of Sciences of the United States of America
Vidal-Gadea A, Topper S, Young L, Crisp A, Kressin L, Elbel E, Maples T, Brauner M, Erbguth K, Axelrod A, Gottschalk A, Siegel D, Pierce-Shimomura JT PubMed 

Optogenetic analysis of GABAB receptor signaling in Caenorhabditis elegans motor neurons. 
Journal of neurophysiology
Schultheis C, Brauner M, Liewald JF, Gottschalk A PubMed 

Optogenetic long-term manipulation of behavior and animal development. 
PloS one
Schultheis C, Liewald JF, Bamberg E, Nagel G, Gottschalk A PubMed 

Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans. 
Nature methods
Stirman JN, Crane MM, Husson SJ, Wabnig S, Schultheis C, Gottschalk A, Lu H PubMed 

PACα--an optogenetic tool for in vivo manipulation of cellular cAMP levels, neurotransmitter release, and behavior in Caenorhabditis elegans. 
Journal of neurochemistry
Weissenberger S, Schultheis C, Liewald JF, Erbguth K, Nagel G, Gottschalk A PubMed 

High-throughput study of synaptic transmission at the neuromuscular junction enabled by optogenetics and microfluidics. 
Journal of neuroscience methods
Stirman JN, Brauner M, Gottschalk A, Lu H PubMed 

An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse. 
The EMBO journal
Almedom RB, Liewald JF, Hernando G, Schultheis C, Rayes D, Pan J, Schedletzky T, Hutter H, Bouzat C, Gottschalk A PubMed 

The conserved RIC-3 coiled-coil domain mediates receptor-specific interactions with nicotinic acetylcholine receptors. 
Molecular biology of the cell
Biala Y, Liewald JF, Ben-Ami HC, Gottschalk A, Treinin M PubMed 

Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans. 
Proceedings of the National Academy of Sciences of the United States of America
Mahoney TR, Luo S, Round EK, Brauner M, Gottschalk A, Thomas JH, Nonet ML PubMed 

Optogenetic analysis of synaptic function. 
Nature methods
Liewald JF, Brauner M, Stephens GJ, Bouhours M, Schultheis C, Zhen M, Gottschalk A PubMed 

Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50. 
The EMBO journal
Eimer S, Gottschalk A, Hengartner M, Horvitz HR, Richmond J, Schafer WR, Bessereau JL PubMed 

Multimodal fast optical interrogation of neural circuitry. 
Zhang F, Wang LP, Brauner M, Liewald JF, Kay K, Watzke N, Wood PG, Bamberg E, Nagel G, Gottschalk A, Deisseroth K PubMed 

Visualization of integral and peripheral cell surface proteins in live Caenorhabditis elegans. 
Journal of neuroscience methods
Gottschalk A, Schafer WR PubMed 

Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses. 
Current biology : CB
Nagel G, Brauner M, Liewald JF, Adeishvili N, Bamberg E, Gottschalk A PubMed 

Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. 
The EMBO journal
Gottschalk A, Almedom RB, Schedletzky T, Anderson SD, Yates JR, Schafer WR PubMed 

eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx. 
McKay JP, Raizen DM, Gottschalk A, Schafer WR, Avery L PubMed 

Direct probing of RNA structure and RNA-protein interactions in purified HeLa cell's and yeast spliceosomal U4/U6.U5 tri-snRNP particles. 
Journal of molecular biology
Mougin A, Gottschalk A, Fabrizio P, Lührmann R, Branlant C PubMed 

A novel yeast U2 snRNP protein, Snu17p, is required for the first catalytic step of splicing and for progression of spliceosome assembly. 
Molecular and Cellular Biology Volume: 21 Issue: 9 Pages: 3037-3046 Published: MAY 2001
Gottschalk, A; Bartels, C; Neubauer, G; et al. PubMed 

The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p. 
RNA Volume: 7 Issue: 11 Pages: 1554-65 Published: 2001
Gottschalk, A.; Kastner, B.; Lührmann, R.; et al. PubMed 

Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6-U5] tri-snRNP. 
Embo Journal Volume: 18 Issue: 16 Pages: 4535-4548 Published: AUG 16 1999
Author(s): Gottschalk, A; Neubauer, G; Banroques, J; et al. PubMed 

Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection. 
Optogenetics (de Gruyter; Dahlem Conference reports)
Genes Dev Volume: 13 Issue: 5 Pages: 569-80 Published: 1999 PubMed 

A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins. 
RNA Volume: 4 Issue: 4 Pages: 374-93 Published: 1998
Gottschalk, A.; Tang, J.; Puig, O.; et al. PubMed 

Cbf5p, a potential pseudouridine synthase, and Nhp2p, a putative RNA-binding protein, are present together with Gar1p in all H BOX/ACA-motif snoRNPs and constitute a common bipartite structure. 
RNA Volume: 4 Issue: 12 Pages: 1549-68 Published: 1998
Watkins, N. J.; Gottschalk, A.; Neubauer, G.; et al. PubMed 

Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry. 
Proc Natl Acad Sci U S A Volume: 94 Issue: 2 Pages: 385-90 Published: 1997
Neubauer, G.; Gottschalk, A.; Fabrizio, P.; et al PubMed