Research Groups

 

Publications of Xinlai Cheng (Results: 35)

 

Effect of Constant and Fluctuating Temperature on the Development, Reproduction, Survival, and Sex Ratio of Phenacoccus solenopsis (Hemiptera: Pseudococcidae).
Environmental entomology
Waqas MS, Lin L, Shoaib AAZ, Cheng X, Zhang Q, Elabasy ASS, Shi Z PubMed
Mar 2020 Volume: Issue: Pages:

NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice.
Communications biology
Cheng X, Haeberle S, Luca Shytaj I, Gama-Brambila RA, Theobald J, Ghafoory S, Wölker J, Basu U, Schmidt C, Timm A, Taškova K, Bauer AS, Hoheisel J, Tsopoulidis N, Fackler OT, Savarino A, Andrade-Navarro MA, Ott I, Lusic M, Hadaschik EN, Wölfl S PubMed
Jan 2020 Volume: 3 Issue: 1 Pages: 10

NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice.
Communications biology
Cheng X, Haeberle S, Luca Shytaj I, Gama-Brambila RA, Theobald J, Ghafoory S, Wölker J, Basu U, Schmidt C, Timm A, Taškova K, Bauer AS, Hoheisel J, Tsopoulidis N, Fackler OT, Savarino A, Andrade-Navarro MA, Ott I, Lusic M, Hadaschik EN, Wölfl S PubMed
2020 Volume: 3 Issue: Pages: 10

Pro-oxidant and lifespan extension effects of caffeine and related methylxanthines in .
Food chemistry: X
Li H, Roxo M, Cheng X, Zhang S, Cheng H, Wink M PubMed
Mar 2019 Volume: 1 Issue: Pages: 100005

p53-Dependent Anti-Proliferative and Pro-Apoptotic Effects of a Gold(I) -Heterocyclic Carbene (NHC) Complex in Colorectal Cancer Cells.
Frontiers in oncology
Dabiri Y, Abu El Maaty MA, Chan HY, Wölker J, Ott I, Wölfl S, Cheng X PubMed
2019 Volume: 9 Issue: Pages: 438

In vitro metabolic activation of vitamin D3 by using a multi-compartment microfluidic liver-kidney organ on chip platform.
Scientific reports
Theobald J, Abu El Maaty MA, Kusterer N, Wetterauer B, Wink M, Cheng X, Wölfl S PubMed
03 2019 Volume: 9 Issue: 1 Pages: 4616

Lethal and Sublethal Effects of Neonicotinoid Insecticides on the Adults of Phenacoccus solenopsis (Hemiptera: Pseudococcidae) on Tomato Plants.
Journal of economic entomology
Waqas MS, Qian L, Shoaib AAZ, Cheng X, Zhang Q, Elabasy ASS, Shi Z PubMed
05 2019 Volume: 112 Issue: 3 Pages: 1314-1321

Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs.
iScience
Dabiri Y, Gama-Brambila RA, Taškova K, Herold K, Reuter S, Adjaye J, Utikal J, Mrowka R, Wang J, Andrade-Navarro MA, Cheng X PubMed
Feb 2019 Volume: 12 Issue: Pages: 168-181

A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway.
International journal of molecular sciences
Dabiri Y, Schmid A, Theobald J, Blagojevic B, Streciwilk W, Ott I, Wölfl S, Cheng X PubMed
Dec 2018 Volume: 19 Issue: 12 Pages:

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction.
European journal of medicinal chemistry
Streciwilk W, Terenzi A, Cheng X, Hager L, Dabiri Y, Prochnow P, Bandow JE, Wölfl S, Keppler BK, Ott I PubMed
Aug 2018 Volume: 156 Issue: Pages: 148-161

Author Correction: Essential role of mitochondrial Stat3 in p38 mediated apoptosis under oxidative stress.
Scientific reports
Cheng X, Peuckert C, Wölfl S PubMed
Apr 2018 Volume: 8 Issue: 1 Pages: 6119

Monitoring cytochrome P450 activity in living hepatocytes by chromogenic substrates in response to drug treatment or during cell maturation.
Archives of toxicology
Theobald J, Cheng X, Ghanem A, Gaitantzi H, Song G, Klipp E, Wodke J, Becker H, Mrowka R, Breitkopf-Heinlein K, Dooley S, Wölfl S PubMed
Mar 2018 Volume: 92 Issue: 3 Pages: 1133-1149

Essential role of mitochondrial Stat3 in p38 mediated apoptosis under oxidative stress.
Scientific reports
Cheng X, Peuckert C, Wölfl S PubMed
11 2017 Volume: 7 Issue: 1 Pages: 15388

The essential role of TAp73 in bortezomib-induced apoptosis in p53-deficient colorectal cancer cells.
Scientific reports
Dabiri Y, Kalman S, Gürth CM, Kim JY, Mayer V, Cheng X PubMed
07 2017 Volume: 7 Issue: 1 Pages: 5423

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.
Journal of medicinal chemistry
Cheng X, Merz KH, Vatter S, Zeller J, Muehlbeyer S, Thommet A, Christ J, Wölfl S, Eisenbrand G PubMed
06 2017 Volume: 60 Issue: 12 Pages: 4949-4962

Human microRNA-299-3p decreases invasive behavior of cancer cells by downregulation of Oct4 expression and causes apoptosis.
PloS one
Göhring AR, Reuter S, Clement JH, Cheng X, Theobald J, Wölfl S, Mrowka R PubMed
2017 Volume: 12 Issue: 4 Pages: e0174912

Acidic stress induced G1 cell cycle arrest and intrinsic apoptotic pathway in Jurkat T-lymphocytes.
Experimental cell research
Kim JY, Cheng X, Wölfl S PubMed
Jan 2017 Volume: 350 Issue: 1 Pages: 140-146

The Role of Indirubins in Inflammation and Associated Tumorigenesis.
Advances in experimental medicine and biology
Cheng X, Merz KH PubMed
2016 Volume: 929 Issue: Pages: 269-290

Modified STAP conditions facilitate bivalent fate decision between pluripotency and apoptosis in Jurkat T-lymphocytes.
Biochemical and biophysical research communications
Kim JY, Cheng X, Alborzinia H, Wölfl S PubMed
Apr 2016 Volume: 472 Issue: 4 Pages: 585-91

Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.
Molecular oncology
Cheng X, Kim JY, Ghafoory S, Duvaci T, Rafiee R, Theobald J, Alborzinia H, Holenya P, Fredebohm J, Merz KH, Mehrabi A, Hafezi M, Saffari A, Eisenbrand G, Hoheisel JD, Wölfl S PubMed
06 2016 Volume: 10 Issue: 6 Pages: 806-24

Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4.
Journal of medicinal chemistry
Cheng X, Yoshida H, Raoofi D, Saleh S, Alborzinia H, Wenke F, Göhring A, Reuter S, Mah N, Fuchs H, Andrade-Navarro MA, Adjaye J, Gul S, Utikal J, Mrowka R, Wölfl S PubMed
Aug 2015 Volume: 58 Issue: 15 Pages: 5742-50

Cytotoxicity of arctigenin and matairesinol against the T-cell lymphoma cell line CCRF-CEM.
The Journal of pharmacy and pharmacology
Su S, Cheng X, Wink M PubMed
Sep 2015 Volume: 67 Issue: 9 Pages: 1316-23

Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers.
Journal of medicinal chemistry
Cheng X, Dimou E, Alborzinia H, Wenke F, Göhring A, Reuter S, Mah N, Fuchs H, Andrade-Navarro MA, Adjaye J, Gul S, Harms C, Utikal J, Klipp E, Mrowka R, Wölfl S PubMed
Jun 2015 Volume: 58 Issue: 12 Pages: 4976-83

Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Su S, Cheng X, Wink M PubMed
Feb 2015 Volume: 22 Issue: 2 Pages: 301-7

A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.
Molecular cancer
Cheng X, Holenya P, Can S, Alborzinia H, Rubbiani R, Ott I, Wölfl S PubMed
Sep 2014 Volume: 13 Issue: Pages: 221

In vitro and in vivo evaluations of the performance of an indirubin derivative, formulated in four different self-emulsifying drug delivery systems.
The Journal of pharmacy and pharmacology
Heshmati N, Cheng X, Dapat E, Sassene P, Eisenbrand G, Fricker G, Müllertz A PubMed
Nov 2014 Volume: 66 Issue: 11 Pages: 1567-75

Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.
Metallomics : integrated biometal science
Holenya P, Can S, Rubbiani R, Alborzinia H, Jünger A, Cheng X, Ott I, Wölfl S PubMed
Sep 2014 Volume: 6 Issue: 9 Pages: 1591-601

7,7'-Diazaindirubin--a small molecule inhibitor of casein kinase 2 in vitro and in cells.
Bioorganic & medicinal chemistry
Cheng X, Merz KH, Vatter S, Christ J, Wölfl S, Eisenbrand G PubMed
Jan 2014 Volume: 22 Issue: 1 Pages: 247-55

Physicochemical characterization and in vitro permeation of an indirubin derivative.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Heshmati N, Wagner B, Cheng X, Scholz T, Kansy M, Eisenbrand G, Fricker G PubMed
Nov 2013 Volume: 50 Issue: 3-4 Pages: 467-75

Enhancement of oral bioavailability of E804 by self-nanoemulsifying drug delivery system (SNEDDS) in rats.
Journal of pharmaceutical sciences
Heshmati N, Cheng X, Eisenbrand G, Fricker G PubMed
Oct 2013 Volume: 102 Issue: 10 Pages: 3792-9

Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells.
Molecular oncology
Nam S, Wen W, Schroeder A, Herrmann A, Yu H, Cheng X, Merz KH, Eisenbrand G, Li H, Yuan YC, Jove R PubMed
Jun 2013 Volume: 7 Issue: 3 Pages: 369-78

Indirubin derivatives modulate TGFβ/BMP signaling at different levels and trigger ubiquitin-mediated depletion of nonactivated R-Smads.
Chemistry & biology
Cheng X, Alborzinia H, Merz KH, Steinbeisser H, Mrowka R, Scholl C, Kitanovic I, Eisenbrand G, Wölfl S PubMed
Nov 2012 Volume: 19 Issue: 11 Pages: 1423-36

Quantitative kinetics analysis of BMP2 uptake into cells and its modulation by BMP antagonists.
Journal of cell science
Alborzinia H, Schmidt-Glenewinkel H, Ilkavets I, Breitkopf-Heinlein K, Cheng X, Hortschansky P, Dooley S, Wölfl S PubMed
Jan 2013 Volume: 126 Issue: Pt 1 Pages: 117-27

Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling.
Molecular oncology
Nam S, Scuto A, Yang F, Chen W, Park S, Yoo HS, Konig H, Bhatia R, Cheng X, Merz KH, Eisenbrand G, Jove R PubMed
Jun 2012 Volume: 6 Issue: 3 Pages: 276-83

Synthesis and cytotoxicity of novel indirubin-5-carboxamides.
Bioorganic & medicinal chemistry
Cheng X, Rasqué P, Vatter S, Merz KH, Eisenbrand G PubMed
Jun 2010 Volume: 18 Issue: 12 Pages: 4509-15