Projects in Computational RNA Biology
- Project 1
Our group develops and applies computational approaches to investigate the molecular mechanisms of posttranscriptional regulation. Our projects follow three main research themes:
(i) In close collaboration with experimental labs, we investigate the function of key RBPs, such as hnRNP A1 and PTB, in splicing regulation and dissect the serious consequences of their dysfunction on human health.
(ii) We exploit first-hand experimental data as well as publicly available datasets to extract the molecular rules that underlie regulatory decisions, such as the choice of adjacent splice sites.
(iii) We develop pipelines to screen clinical RNA-seq data for pseudoexonisation events and other types of erroneous transcript processing and to link these to the responsible regulators.