Research Groups

 

Publications of Masato Akutsu (Results: 35)

 

Characterization of a novel cysteine-less Cu/Zn-superoxide dismutase in Paenibacillus lautus missing a conserved disulfide bond.
The Journal of biological chemistry
Furukawa Y, Shintani A, Narikiyo S, Sue K, Akutsu M, Muraki N PubMed
Aug 2023 Volume: 299 Issue: 8 Pages: 105040

Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation.
The Journal of biological chemistry
Hashimoto K, Watanabe S, Akutsu M, Muraki N, Kamishina H, Furukawa Y, Yamanaka K PubMed
Jun 2023 Volume: 299 Issue: 6 Pages: 104798

The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.
Nature communications
Maurer MF, Lewis KE, Kuijper JL, Ardourel D, Gudgeon CJ, Chandrasekaran S, Mudri SL, Kleist KN, Navas C, Wolfson MF, Rixon MW, Swanson R, Dillon SR, Levin SD, Kimbung YR, Akutsu M, Logan DT, Walse B, Swiderek KM, Peng SL PubMed
Apr 2022 Volume: 13 Issue: 1 Pages: 1790

Non-conventional octameric structure of C-phycocyanin.
Communications biology
Minato T, Teramoto T, Adachi N, Hung NK, Yamada K, Kawasaki M, Akutsu M, Moriya T, Senda T, Ogo S, Kakuta Y, Yoon KS PubMed
Oct 2021 Volume: 4 Issue: 1 Pages: 1238

Demonstrating Ligandability of the LC3A and LC3B Adapter Interface.
Journal of medicinal chemistry
Hartmann M, Huber J, Kramer JS, Heering J, Pietsch L, Stark H, Odadzic D, Bischoff I, Fürst R, Schröder M, Akutsu M, Chaikuad A, Dötsch V, Knapp S, Biondi RM, Rogov VV, Proschak E PubMed
Apr 2021 Volume: 64 Issue: 7 Pages: 3720-3746

Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Cell chemical biology
Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M, Dikic I PubMed
Nov 2020 Volume: 27 Issue: 11 Pages: 1441-1451.e7

Wss1 Promotes Replication Stress Tolerance by Degrading Histones.
Cell reports
Maddi K, Sam DK, Bonn F, Prgomet S, Tulowetzke E, Akutsu M, Lopez-Mosqueda J, Dikic I PubMed
Mar 2020 Volume: 30 Issue: 9 Pages: 3117-3126.e4

An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.
Autophagy
Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Güntert P, Dikic I, Kirkin V, Komatsu M, Dötsch V, Rogov VV PubMed
Feb 2020 Volume: 16 Issue: 2 Pages: 256-270

p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage.
Nature communications
Borisova ME, Voigt A, Tollenaere MAX, Sahu SK, Juretschke T, Kreim N, Mailand N, Choudhary C, Bekker-Jensen S, Akutsu M, Wagner SA, Beli P PubMed
Mar 2018 Volume: 9 Issue: 1 Pages: 1017

Structural Basis for the Serratia marcescens Lipase Secretion System: Crystal Structures of the Membrane Fusion Protein and Nucleotide-Binding Domain.
Biochemistry
Murata D, Okano H, Angkawidjaja C, Akutsu M, Tanaka SI, Kitahara K, Yoshizawa T, Matsumura H, Kado Y, Mizohata E, Inoue T, Sano S, Koga Y, Kanaya S, Takano K PubMed
Nov 2017 Volume: 56 Issue: 47 Pages: 6281-6291

Ubiquitin-dependent regulation of Cdc42 by XIAP.
Cell death & disease
Murali A, Shin J, Yurugi H, Krishnan A, Akutsu M, Carpy A, Macek B, Rajalingam K PubMed
Jun 2017 Volume: 8 Issue: 6 Pages: e2900

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature
Mevissen TET, Kulathu Y, Mulder MPC, Geurink PP, Maslen SL, Gersch M, Elliott PR, Burke JE, van Tol BDM, Akutsu M, Oualid FE, Kawasaki M, Freund SMV, Ovaa H, Komander D PubMed
Oct 2016 Volume: 538 Issue: 7625 Pages: 402-405

Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation.
The Journal of biological chemistry
Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V PubMed
Apr 2016 Volume: 291 Issue: 17 Pages: 9025-41

Ubiquitin chain diversity at a glance.
Journal of cell science
Akutsu M, Dikic I, Bremm A PubMed
Mar 2016 Volume: 129 Issue: 5 Pages: 875-80

TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.
Molecular cell
Stadel D, Millarte V, Tillmann KD, Huber J, Tamin-Yecheskel BC, Akutsu M, Demishtein A, Ben-Zeev B, Anikster Y, Perez F, Dötsch V, Elazar Z, Rogov V, Farhan H, Behrends C PubMed
Oct 2015 Volume: 60 Issue: 1 Pages: 89-104

Regulation of endoplasmic reticulum turnover by selective autophagy.
Nature
Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I PubMed
Jun 2015 Volume: 522 Issue: 7556 Pages: 354-8

CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
Molecular cell
Genau HM, Huber J, Baschieri F, Akutsu M, Dötsch V, Farhan H, Rogov V, Behrends C PubMed
Mar 2015 Volume: 57 Issue: 6 Pages: 995-1010

PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.
Cell host & microbe
McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic I PubMed
Jan 2015 Volume: 17 Issue: 1 Pages: 58-71

Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling.
Molecular cell
Schaeffer V, Akutsu M, Olma MH, Gomes LC, Kawasaki M, Dikic I PubMed
May 2014 Volume: 54 Issue: 3 Pages: 349-61

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.
Cell
Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D PubMed
Jul 2013 Volume: 154 Issue: 1 Pages: 169-84

An essential role for the ATG8 ortholog LC3C in antibacterial autophagy.
Autophagy
von Muhlinen N, Akutsu M, Ravenhill BJ, Foeglein Á, Bloor S, Rutherford TJ, Freund SM, Komander D, Randow F PubMed
May 2013 Volume: 9 Issue: 5 Pages: 784-6

LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy.
Molecular cell
von Muhlinen N, Akutsu M, Ravenhill BJ, Foeglein Á, Bloor S, Rutherford TJ, Freund SM, Komander D, Randow F PubMed
Nov 2012 Volume: 48 Issue: 3 Pages: 329-42

Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.
Molecular and cellular biology
Popovic D, Akutsu M, Novak I, Harper JW, Behrends C, Dikic I PubMed
May 2012 Volume: 32 Issue: 9 Pages: 1733-44

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.
Nature structural & molecular biology
Licchesi JD, Mieszczanek J, Mevissen TE, Rutherford TJ, Akutsu M, Virdee S, El Oualid F, Chin JW, Ovaa H, Bienz M, Komander D PubMed
Dec 2011 Volume: 19 Issue: 1 Pages: 62-71

Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.
EMBO reports
Ye Y, Akutsu M, Reyes-Turcu F, Enchev RI, Wilkinson KD, Komander D PubMed
Apr 2011 Volume: 12 Issue: 4 Pages: 350-7

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
Proceedings of the National Academy of Sciences of the United States of America
Akutsu M, Ye Y, Virdee S, Chin JW, Komander D PubMed
Feb 2011 Volume: 108 Issue: 6 Pages: 2228-33

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.
Nature structural & molecular biology
Kulathu Y, Akutsu M, Bremm A, Hofmann K, Komander D PubMed
Dec 2009 Volume: 16 Issue: 12 Pages: 1328-30

Structure and function of the PLAA/Ufd3-p97/Cdc48 complex.
The Journal of biological chemistry
Qiu L, Pashkova N, Walker JR, Winistorfer S, Allali-Hassani A, Akutsu M, Piper R, Dhe-Paganon S PubMed
Jan 2010 Volume: 285 Issue: 1 Pages: 365-72

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.
Cell
Rahighi S, Ikeda F, Kawasaki M, Akutsu M, Suzuki N, Kato R, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki S, Dikic I PubMed
Mar 2009 Volume: 136 Issue: 6 Pages: 1098-109

Structural basis and specificity of human otubain 1-mediated deubiquitination.
The Biochemical journal
Edelmann MJ, Iphöfer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM PubMed
Mar 2009 Volume: 418 Issue: 2 Pages: 379-90

In situ proteolysis for protein crystallization and structure determination.
Nature methods
Dong A, Xu X, Edwards AM, , , Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P, Flodin S, Flores A, Gräslund S, Hammerström M, Herman MD, Hong BS, Hui R, Johansson I, Li... PubMed
Dec 2007 Volume: 4 Issue: 12 Pages: 1019-21

Development of an automated large-scale protein-crystallization and monitoring system for high-throughput protein-structure analyses.
Acta crystallographica. Section D, Biological crystallography
Hiraki M, Kato R, Nagai M, Satoh T, Hirano S, Ihara K, Kudo N, Nagae M, Kobayashi M, Inoue M, Uejima T, Oda S, Chavas LM, Akutsu M, Yamada Y, Kawasaki M, Matsugaki N, Igarashi N, Suzuki M, Wakatsuki S PubMed
Sep 2006 Volume: 62 Issue: Pt 9 Pages: 1058-65

Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain.
FEBS letters
Akutsu M, Kawasaki M, Katoh Y, Shiba T, Yamaguchi Y, Kato R, Kato K, Nakayama K, Wakatsuki S PubMed
Oct 2005 Volume: 579 Issue: 24 Pages: 5385-91

Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
The Journal of general virology
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H PubMed
Apr 2004 Volume: 85 Issue: Pt 4 Pages: 959-969

Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins.
Microbiology and immunology
Oka K, Nagano-Fujii M, Yoshida I, Hidajat R, Deng L, Akutsu M, Hotta H PubMed
2003 Volume: 47 Issue: 6 Pages: 429-38