Members of the Biomolecular Chemistry Group
Prof. Dr. Martin Grininger
Professor for Biomolecular Chemistry &
Group Leader
Professor & Group Leader
Phone: +49 (0)69 798-42705
grininger(at)chemie.uni-frankfurt.de
Website
Martin was a project leader in the group of Prof. Dieter Oesterhelt at the Max Planck Institute of Biochemistry, Martinsried before he moved to Goethe University Frankfurt in 2012 as Lichtenberg Professor of the Volkswagen Foundation.
Curriculum Vitae | |
since 2020 | Professor (permanent) for Biomolecular Chemistry, Institute for Organic Chemistry and Chemical Biology |
2015 -2017 | Vice-Director Buchmann Institute for Molecular Life Sciences (BMLS) (Buchmann Institut für die molekularen Lebesnwissenschaften, Frankfurt am Main, Germany) |
2012-2019 | Lichtenberg-Professor, Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence "Macromolecular Complexes", Goethe University Frankfurt |
2010-2011 | Guest Professor, University of Vienna, Faculty of Chemistry, Austria |
2006-2011 | Group Leader of project group "Biological Chemistry", Max-Planck-Institute of Biochemistry, Martinsried near Munich, Germany |
2002-2006 | PhD, Ludwig Maximilians University Munich, Germany |
2001-2002 | Diploma in Chemistry, Technical University Graz, Austria |
Awards and Fellowships | |
2017 | LOEWE Research Cluster MegaSyn (Speaker) |
2014 | Preis für Exzellente Lehre am Fachbereich Biochemie, Chemie und Pharmazie der Goethe Universitüt Frankfurt |
2007 | Max-Planck-Institute of Biochemistry Junior Research Award |
2001 | Leonardo da Vinci Fellowship |
Selected Publications |
Chemoenzymatic synthesis of fluorinated polyketides. Rittner A, Joppe M, Schmidt JJ, Mayer LM, Reiners S, Heid E, Herzberg D, Sherman DH, Grininger M. (2022) https://rdcu.be/cTf1n
Solution Structure and Conformational Flexibility of a Polyketide Synthase Module. Klaus M, Rossini E, Linden A, Paithankar KS, Zeug M, Ignatova Z, Urlaub H, Khosla C, Köfinger J, Hummer G, Grininger M. (2021) JACS Au jacsau.1c00043 Transacylation Kinetics in Fatty Acid and Polyketide Synthases and Its Sensitivity to Point Mutations. Stegemann F, Grininger M. (2021) ChemCatChem, 13, 2771–2782. (Front Cover: ChemCatChem 2021, 13, 2743.) ACS Synth Biol. 9, 2418-2426. The Ketosynthase Domain Constrains the Design of Polyketide Synthases. Klaus M, Buyachuihan L, Grininger M. (2020) ACS Chem Biol. DOI: 10.1021/acschembio.0c00405. Protein denaturation at the water-air interface and how to prevent it. D'Imprima E, Floris D, Joppe M., Sánchez R, Grininger M, Kühlbrandt W. (2019) eLife 2019;8:e42747. Characterization of the polyspecific transferase of murine type I fatty acid synthase (FAS) and implications for polyketide synthase (PKS) engineering.Rittner A, Paithankar KS, Vu Huu K, Grininger M. (2018) ACS Chem Biol. 3, 723-732. Engineering fungal de novo fatty acid synthesis for short chain fatty acid production.Gajewski J, Pavlovic R, Fischer M, Boles E, Grininger M. (2017) Nat Commun. 8, 14650. Expanding the product portfolio of fungal type I fatty acid synthases. Zhu Z, Zhou YJ, Krivoruchko A, Grininger M, Zhao ZK, Nielsen J. (2017) Nat Chem Biol. 13, 360-362. Engineering fatty acid synthases for directed polyketide production. Gajewski J, Buelens F, Serdjukow S, Janßen M, Cortina N, Grubm¨ller H, Grininger M. (2017) Nat Chem Biol. 13, 363-365. (Front Cover and highlighted in News and Views: Maier T. (2017) Fatty acid synthases: Re-engineering biofactories. Nat Chem Biol. 13, 344-345. |
Administrative Assistant
Phone: +49 (0)69 798-29233
office.grininger(at)chemie.uni-frankfurt.de