Research Groups

Members of the Biomolecular Chemistry Group

Prof. Dr. Martin Grininger
Lichtenberg (W1)-Professor of the Volkswagen Foundation &
Group Leader

Professor & Group Leader
Phone: +49 (0)69 798-42705

Martin was a project leader in the group of Prof. Dieter Oesterhelt at the Max Planck Institute of Biochemistry, Martinsried before he moved to Goethe University Frankfurt in 2012 as Lichtenberg Professor of the Volkswagen Foundation.

Curriculum Vitae  
2015 -2017 Vice-Director Buchmann Institute for Molecular Life Sciences (BMLS)
(Buchmann Institut fΓΌr die molekularen Lebesnwissenschaften, Frankfurt am Main, Germany)
since 2012 Lichtenberg-Professor, Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence "Macromolecular Complexes", Goethe University Frankfurt
2010-2011 Guest Professor, University of Vienna, Faculty of Chemistry, Austria
2006-2011 Group Leader of project group "Biological Chemistry", Max-Planck-Institute of Biochemistry, Martinsried near Munich, Germany
2002-2006 PhD, Ludwig Maximilians University Munich, Germany
2001-2002 Diploma in Chemistry, Technical University Graz, Austria
Awards and Fellowships  
2014 Preis fΓΌr Exzellente Lehre am Fachbereich Biochemie, Chemie und Pharmazie der Goethe UniversitΓt Frankfurt
2007 Max-Planck-Institute of Biochemistry Junior Research Award
2001 Leonardo da Vinci Fellowship
Directed manipulation of a flavoprotein photocycle. Staudt, H; Hoesl, MG; Dreuw, A; Serdjukow, S; Oesterhelt, D; Budisa, N; Wachtveitl, J; Grininger, M; Angew Chem Int Ed Engl, 2013 Aug PubMed

Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex. Ciccarelli, L; Connell, SR; Enderle, M; Mills, DJ; Vonck, J; Grininger, M; Structure, 2013 Jul PubMed

The flavoprotein dodecin as a redox probe for electron transfer through DNA. Yu, Y; Heidel, B; Parapugna, TL; Wenderhold-Reeb, S; Song, B; SchΓΆnherr, H; Grininger, M; NΓΆll, G; Angew Chem Int Ed Engl, 2013 Apr PubMed

Ultrafast excited-state deactivation of flavins bound to dodecin. Staudt, H; Oesterhelt, D; Grininger, M; Wachtveitl, J; J Biol Chem, 2012 May PubMed

Mechanism of substrate shuttling by the acyl-carrier protein within the fatty acid mega-synthase. Anselmi, C; Grininger, M; Gipson, P; Faraldo-GΓ³mez, JD; J Am Chem Soc, 2010 Sep PubMed

Structural and biochemical characterization of a halophilic archaeal alkaline phosphatase. Wende, A; Johansson, P; Vollrath, R; Dyall-Smith, M; Oesterhelt, D; Grininger, M; J Mol Biol, 2010 Jul PubMed

Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy. Gipson, P; Mills, DJ; Wouts, R; Grininger, M; Vonck, J; KΓΌhlbrandt, W; Proc Natl Acad Sci U S A, 2010 May PubMed

Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase. Johansson, P; Mulinacci, B; Koestler, C; Vollrath, R; Oesterhelt, D; Grininger, M; Structure, 2009 Aug PubMed

Blue-light-triggered photorelease of active chemicals captured by the flavoprotein dodecin. NΓΆll, G; TrawΓΆger, S; von Sanden-Flohe, M; Dick, B; Grininger, M; Chembiochem, 2009 Mar PubMed

Dodecin is the key player in flavin homeostasis of archaea. Grininger, M; Staudt, H; Johansson, P; Wachtveitl, J; Oesterhelt, D; J Biol Chem, 2009 May PubMed

Electrochemical switching of the flavoprotein dodecin at gold surfaces modified by flavin-DNA hybrid linkers. Grininger, M; NΓΆll, G; TrawΓΆger, S; Sinner, EK; Oesterhelt, D; Biointerphases, 2008 Sep PubMed

Inhibition of the fungal fatty acid synthase type I multienzyme complex. Johansson, P; Wiltschi, B; Kumari, P; Kessler, B; Vonrhein, C; Vonck, J; Oesterhelt, D; Grininger, M; Proc Natl Acad Sci U S A, 2008 Sep PubMed

Dodecin sequesters FAD in closed conformation from the aqueous solution. Grininger, M; Seiler, F; Zeth, K; Oesterhelt, D; J Mol Biol, 2006 Dec PubMed

Dodecins: a family of lumichrome binding proteins. Grininger, M; Zeth, K; Oesterhelt, D; J Mol Biol, 2006 Mar PubMed

Parameters affecting the X-ray dose absorbed by macromolecular crystals. Murray, JW; RudiΓ±o-PiΓ±era, E; Owen, RL; Grininger, M; Ravelli, RB; Garman, EF; J Synchrotron Radiat, 2005 May PubMed

Expression, crystallization and crystallographic analysis of DegS, a stress sensor of the bacterial periplasm. Grininger, M; Ravelli, RB; Heider, U; Zeth, K; Acta Crystallogr D Biol Crystallogr, 2004 Aug PubMed
Nataliya Kasanzeva

Administrative Assistant
Phone: +49 (0)69 798-46466

Ilka Siebels

Technical Assistant
Phone: +49 (0)69 798-42533

Dr. Karthik S. Paithankar

Postdoctoral Fellow
Phone: +49 (0)69 798-42533

Dr.rer.nat from University of Leipzig. After a post-doc in the Garman group at the University of Oxford, he was a beamline scientist at BESSY II synchrotron at Helmholtz-Zentrum Berlin.
His favorite pastime is coding and learning natural languages.

Dr. Manuel Fischer

Postdoctoral Fellow
Phone: +49 (0)69 798-42533

Manuel studied chemistry at the Goethe University of Frankfurt focused on organic synthesis. In his PhD thesis, Manuel evaluates new strategies for the inhibition of fatty acid synthases.

Dr. Max Hützler

Postdoctoral Fellow
Phone: +49 (0)69 798-29232

Alexander Rittner

PhD Student
Phone: +49 (0)69 798-42533

After studying biomedical chemistry until the "Vordiplom" in Mainz, Alex moved to Munich and did his bachelor's and master's degree in biochemistry at the Ludwig Maximilian University. His master's thesis was written in Zurich with Prof. PlΓΌckthun on G-protein coupled receptors. Alex joined the lab as a PhD student to work on the mammalian FAS, particularly on the human FAS.

Christina Heil

PhD Student
Phone: +49 (0)69 798-42533

Christina studied chemistry at the Goethe-University Frankfurt with a focus on chemical biology. During her master, she
performed structural studies on proteins at University of TromsΓΈ. Her doctoral thesis involves conformational studies of
multi-functional proteins.

Florian Bourdeaux

PhD Student
Phone: +49 (0)69 798-42533

Florian studied chemistry at the Goethe-University Frankfurt. During his bachelor, he focused on analytic and surface chemistry. Through his master, he switched to biochemistry and did a master thesis on Mycobacterium tuberculosis Dodecin. In his PhD, Florian is working on functional studies of large proteins.

Maja Klaus

PhD Student
Phone: +49 (0)69 798-42533

Maja studied Life Science at the Leibniz University Hannover with a focus on molecular biology and chemistry of natural products with
a master's thesis from Stanford. In summer 2015, Maja joined the lab as a PhD student.

Mirko Joppe

PhD Student
Phone: +49 (0)69 798-29232

Franziska Stegemann

PhD Student
Phone: +49 (0)69 798-29232