Members of the Biomolecular Chemistry Group
Prof. Dr. Martin Grininger
Professor for Biomolecular Chemistry &
Professor & Group Leader
Phone: +49 (0)69 798-42705
Martin was a project leader in the group of Prof. Dieter Oesterhelt at the Max Planck Institute of Biochemistry, Martinsried before he moved to Goethe University Frankfurt in 2012 as Lichtenberg Professor of the Volkswagen Foundation.
|since 2020||Professor (permanent) for Biomolecular Chemistry, Institute for Organic Chemistry and Chemical Biology|
|2015 -2017||Vice-Director Buchmann Institute for Molecular Life Sciences (BMLS)
(Buchmann Institut für die molekularen Lebesnwissenschaften, Frankfurt am Main, Germany)
|2012-2019||Lichtenberg-Professor, Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence "Macromolecular Complexes", Goethe University Frankfurt|
|2010-2011||Guest Professor, University of Vienna, Faculty of Chemistry, Austria|
|2006-2011||Group Leader of project group "Biological Chemistry", Max-Planck-Institute of Biochemistry, Martinsried near Munich, Germany|
|2002-2006||PhD, Ludwig Maximilians University Munich, Germany|
|2001-2002||Diploma in Chemistry, Technical University Graz, Austria|
|Awards and Fellowships|
|2017||LOEWE Research Cluster MegaSyn (Speaker)|
|2014||Preis für Exzellente Lehre am Fachbereich Biochemie, Chemie und Pharmazie der Goethe Universitüt Frankfurt|
|2007||Max-Planck-Institute of Biochemistry Junior Research Award|
|2001||Leonardo da Vinci Fellowship|
|Chemoenzymatic synthesis of fluorinated polyketides. Rittner A, Joppe M, Schmidt JJ, Mayer LM, Reiners S, Heid E, Herzberg D, Sherman DH, Grininger M. (2022) https://rdcu.be/cTf1n
Solution Structure and Conformational Flexibility of a Polyketide Synthase Module. Klaus M, Rossini E, Linden A, Paithankar KS, Zeug M, Ignatova Z, Urlaub H, Khosla C, Köfinger J, Hummer G, Grininger M. (2021)
JACS Au jacsau.1c00043
Transacylation Kinetics in Fatty Acid and Polyketide Synthases and Its Sensitivity to Point Mutations. Stegemann F, Grininger M. (2021)
ChemCatChem, 13, 2771–2782.
(Front Cover: ChemCatChem 2021, 13, 2743.)
Cell-free synthesis of natural compounds from genomic DNA of biosynthetic gene clusters. Siebels I, Nowak S, Heil CS, Tufar P, Cortina, NS, Bode HB*, Grininger M. (2020)
ACS Synth Biol. 9, 2418-2426.
The Ketosynthase Domain Constrains the Design of Polyketide Synthases. Klaus M, Buyachuihan L, Grininger M. (2020)
ACS Chem Biol. DOI: 10.1021/acschembio.0c00405.
Protein denaturation at the water-air interface and how to prevent it. D'Imprima E, Floris D, Joppe M., Sánchez R, Grininger M, Kühlbrandt W. (2019)
Characterization of the polyspecific transferase of murine type I fatty acid synthase (FAS) and implications for polyketide synthase (PKS) engineering.Rittner A, Paithankar KS, Vu Huu K, Grininger M. (2018)
ACS Chem Biol. 3, 723-732.
Engineering fungal de novo fatty acid synthesis for short chain fatty acid production.Gajewski J, Pavlovic R, Fischer M, Boles E, Grininger M. (2017)
Nat Commun. 8, 14650.
Expanding the product portfolio of fungal type I fatty acid synthases. Zhu Z, Zhou YJ, Krivoruchko A, Grininger M, Zhao ZK, Nielsen J. (2017)
Nat Chem Biol. 13, 360-362.
Engineering fatty acid synthases for directed polyketide production. Gajewski J, Buelens F, Serdjukow S, Janßen M, Cortina N, Grubm¨ller H, Grininger M. (2017)
Nat Chem Biol. 13, 363-365.
(Front Cover and highlighted in News and Views: Maier T. (2017) Fatty acid synthases: Re-engineering biofactories. Nat Chem Biol. 13, 344-345.
Phone: +49 (0)69 798-29233
Phone: +49 (0)69 798-42533
After studying biomedical chemistry until the "Vordiplom" in Mainz, Alex moved to Munich and did his bachelor's and master's degree in biochemistry at the Ludwig Maximilian University. His master's thesis was written in Zurich with Prof. PlΓΌckthun on G-protein coupled receptors. Alex joined the lab as a PhD student to work on the mammalian FAS, particularly on the human FAS.
Phone: +49 (0)69 798-42533
Florian studied chemistry at the Goethe-University Frankfurt. During his bachelor, he focused on analytic and surface chemistry. Through his master, he switched to biochemistry and did a master thesis on Mycobacterium tuberculosis Dodecin. In his PhD, Florian is working on functional studies of large proteins.