Research Groups


Molecular Signaling

Our group focuses on studying molecular mechanisms of the two major degradation pathways – the ubiquitin-proteasome system (UPS) and autophagy. Degradation of cellular components, either through the UPS or the lysosome (autophagy), is essential for maintaining cellular homeostasis. Disruption to either of the processes can lead to cancer, neurodegenerative diseases and other pathologies. It is critical to understand the structure and function of individual components within each of these pathways.

Our lab is equipped with the state-of-the-art technology, allowing us an easy access to the tools and equipment needed to address outstanding questions in the field. This, coupled with the close collaboration with other groups, gives us the opportunity to carry out high-quality science, with the aim for our research to eventually be translated into medicine.

Prof. Dr. Ivan Dikic
Buchmann Institute for
Molecular Life Sciences

Max-von-Laue-Str. 15
60438 Frankfurt am Main

Tel +49 (0)69 6301-5652
Fax +49 (0)69 6301-5577
Email: ivan.dikic(at)