Research Groups


Open Postdoctoral Research Position

In the Buchmann Institute for Molecular Life Sciences in the field of Molecular Biology - Dr. habil. Xinlai Cheng offers positions starting immediately of

A Postdoctoral Researcher (immediately, E13 TV-G-U, 100 %) and/or a Doctoral Researcher (immediately, E13 TV-G-U, 50 %)

The salary grade is based on the job characteristics of the collective agreement applicable to Goethe-university (TV-G-U). The postdoctal position is first limited to 2 years and Doctoral Researcher for 3 years. An extension is possible.

Area of responsibility

The discovery of proximity-induced drugs provides a new therapeutic approach to target currently undruggable proteome. As a part of ProxiDrugs project (Clusters4Future funded by BMBF), this work will be done majorly at the Buchmann Institute for Molecular Life Sciences/Chemical Biology (Frankfurt am Main) in a multi-disciplinary research environment encompassing molecular biology, biochemistry and drug development in close collaboration with other research groups within the ProxiDrugs consortium in Frankfurt, Darmstadt and Heidelberg. The aim of subproject is to identify novel small molecule degraders.

Employment requirements

We are looking for new team members to strengthen our group, who are interested to work on this challenging project at the interface of molecular biology and biochemistry. Applicants should have a degree in Cell Biology or Chemical Biology. Candidates should have excellent experience in Ubiquitination, protein degradation. High level knowledge and good communication skills in English/German are expected. The working group only communicates in English and applications should therefore only be submitted in English. In order to increase the proportion of women in research, we particularly encourage women to apply for this position. The planned research will be carried out in an international research environment at the Life Science Campus Riedberg.

Interested candidates are encouraged to send applications to the following e-mail address as soon as possible: Dr.rer.nat.habil. Xinlai Cheng, cheng@pharmchem.uni-frankfurt,de, Goethe-Universität Buchmann Institute for Molecular Life Sciences; Pharmaceutical Chemistry; Max-von-Laue-Strasse 15. R. 3.652 ; 60438 Frankfurt am Main.

The evaluation will be started immediate till the position is filled

More information related to ProxiDrugs can be found here:

Reference: Gama-Brambila, R. A.; Chen, J.; Zhou, J.; Tascher, G.; Münch, C.; Cheng, X.,* A PROTAC Targets Splicing Factor 3B1. Cell Chemical Biology 2021 Gama-Brambila, R. A.; Chen, J.; Dabiri, Y.; Tascher, G.; Nemec, V.; Münch, C.; Song, G.; knapp, S.; Cheng, X.,* A Chemical Toolbox for Labelling and Degrading Engineered Cas Proteins. JACS Au 2021.