Research Groups


Publications of Martin Grininger (Results: 30)


Engineering strategies for rational polyketide synthase design.
Natural product reports
Klaus M, Grininger M PubMed
Jun 2018 Volume: Issue: Pages:

An engineered fatty acid synthase combined with a carboxylic acid reductase enables de novo production of 1-octanol in .
Biotechnology for biofuels
Henritzi S, Fischer M, Grininger M, Oreb M, Boles E PubMed
2018 Volume: 11 Issue: Pages: 150

Characterization of the small flavin-binding dodecin in the roseoflavin producer Streptomyces davawensis.
Microbiology (Reading, England)
Ludwig P, Sévin DC, Busche T, Kalinowski J, Bourdeaux F, Grininger M, Mack M PubMed
Jun 2018 Volume: 164 Issue: 6 Pages: 908-919

Flavin Storage and Sequestration by Mycobacterium tuberculosis Dodecin.
ACS infectious diseases
Bourdeaux F, Hammer CA, Vogt S, Schweighöfer F, Nöll G, Wachtveitl J, Grininger M PubMed
Jul 2018 Volume: 4 Issue: 7 Pages: 1082-1092

Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering.
ACS chemical biology
Rittner A, Paithankar KS, Huu KV, Grininger M PubMed
Mar 2018 Volume: 13 Issue: 3 Pages: 723-732

Strategies in megasynthase engineering - fatty acid synthases (FAS) as model proteins.
Beilstein journal of organic chemistry
Fischer M, Grininger M PubMed
2017 Volume: 13 Issue: Pages: 1204-1211

Engineering fungal de novo fatty acid synthesis for short chain fatty acid production.
Nature communications
Gajewski J, Pavlovic R, Fischer M, Boles E, Grininger M PubMed
Mar 2017 Volume: 8 Issue: Pages: 14650

Engineering fatty acid synthases for directed polyketide production.
Nature chemical biology
Gajewski J, Buelens F, Serdjukow S, Janßen M, Cortina N, Grubmüller H, Grininger M PubMed
04 2017 Volume: 13 Issue: 4 Pages: 363-365

Expanding the product portfolio of fungal type I fatty acid synthases.
Nature chemical biology
Zhu Z, Zhou YJ, Krivoruchko A, Grininger M, Zhao ZK, Nielsen J PubMed
04 2017 Volume: 13 Issue: 4 Pages: 360-362

Crystallization and X-ray diffraction studies of a complete bacterial fatty-acid synthase type I.
Acta crystallographica. Section F, Structural biology communications
Enderle M, McCarthy A, Paithankar KS, Grininger M PubMed
Nov 2015 Volume: 71 Issue: Pt 11 Pages: 1401-7

Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS.
Protein science : a publication of the Protein Society
Fischer M, Rhinow D, Zhu Z, Mills DJ, Zhao ZK, Vonck J, Grininger M PubMed
Jun 2015 Volume: 24 Issue: 6 Pages: 987-95

Multi-Ligand-Binding Flavoprotein Dodecin as a Key Element for Reversible Surface Modification in Nano-biotechnology.
ACS nano
Gutiérrez Sánchez C, Su Q, Schönherr H, Grininger M, Nöll G PubMed
2015 Volume: 9 Issue: 4 Pages: 3491-500

Modular polyketide synthases (PKSs): a new model fits all?
Chembiochem : a European journal of chemical biology
Rittner A, Grininger M PubMed
Nov 2014 Volume: 15 Issue: 17 Pages: 2489-93

Perspectives on the evolution, assembly and conformational dynamics of fatty acid synthase type I (FAS I) systems.
Current opinion in structural biology
Grininger M PubMed
Apr 2014 Volume: 25 Issue: Pages: 49-56

Directed manipulation of a flavoprotein photocycle.
Angewandte Chemie (International ed. in English)
Staudt H, Hoesl MG, Dreuw A, Serdjukow S, Oesterhelt D, Budisa N, Wachtveitl J, Grininger M PubMed
Aug 2013 Volume: 52 Issue: 32 Pages: 8463-6

Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex.
Structure (London, England : 1993)
Ciccarelli L, Connell SR, Enderle M, Mills DJ, Vonck J, Grininger M PubMed
Jul 2013 Volume: 21 Issue: 7 Pages: 1251-7

The flavoprotein dodecin as a redox probe for electron transfer through DNA.
Angewandte Chemie (International ed. in English)
Yu Y, Heidel B, Parapugna TL, Wenderhold-Reeb S, Song B, Schönherr H, Grininger M, Nöll G PubMed
Apr 2013 Volume: 52 Issue: 18 Pages: 4950-3

Ultrafast excited-state deactivation of flavins bound to dodecin.
The Journal of biological chemistry
Staudt H, Oesterhelt D, Grininger M, Wachtveitl J PubMed
May 2012 Volume: 287 Issue: 21 Pages: 17637-44

Mechanism of substrate shuttling by the acyl-carrier protein within the fatty acid mega-synthase.
Journal of the American Chemical Society
Anselmi C, Grininger M, Gipson P, Faraldo-Gómez JD PubMed
Sep 2010 Volume: 132 Issue: 35 Pages: 12357-64

Structural and biochemical characterization of a halophilic archaeal alkaline phosphatase.
Journal of molecular biology
Wende A, Johansson P, Vollrath R, Dyall-Smith M, Oesterhelt D, Grininger M PubMed
Jul 2010 Volume: 400 Issue: 1 Pages: 52-62

Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy.
Proceedings of the National Academy of Sciences of the United States of America
Gipson P, Mills DJ, Wouts R, Grininger M, Vonck J, Kühlbrandt W PubMed
May 2010 Volume: 107 Issue: 20 Pages: 9164-9

Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase.
Structure (London, England : 1993)
Johansson P, Mulinacci B, Koestler C, Vollrath R, Oesterhelt D, Grininger M PubMed
Aug 2009 Volume: 17 Issue: 8 Pages: 1063-74

Blue-light-triggered photorelease of active chemicals captured by the flavoprotein dodecin.
Chembiochem : a European journal of chemical biology
Nöll G, Trawöger S, von Sanden-Flohe M, Dick B, Grininger M PubMed
Mar 2009 Volume: 10 Issue: 5 Pages: 834-7

Dodecin is the key player in flavin homeostasis of archaea.
The Journal of biological chemistry
Grininger M, Staudt H, Johansson P, Wachtveitl J, Oesterhelt D PubMed
May 2009 Volume: 284 Issue: 19 Pages: 13068-76

Electrochemical switching of the flavoprotein dodecin at gold surfaces modified by flavin-DNA hybrid linkers.
Grininger M, Nöll G, Trawöger S, Sinner EK, Oesterhelt D PubMed
Sep 2008 Volume: 3 Issue: 3 Pages: 51-8

Inhibition of the fungal fatty acid synthase type I multienzyme complex.
Proceedings of the National Academy of Sciences of the United States of America
Johansson P, Wiltschi B, Kumari P, Kessler B, Vonrhein C, Vonck J, Oesterhelt D, Grininger M PubMed
Sep 2008 Volume: 105 Issue: 35 Pages: 12803-8

Dodecin sequesters FAD in closed conformation from the aqueous solution.
Journal of molecular biology
Grininger M, Seiler F, Zeth K, Oesterhelt D PubMed
Dec 2006 Volume: 364 Issue: 4 Pages: 561-6

Dodecins: a family of lumichrome binding proteins.
Journal of molecular biology
Grininger M, Zeth K, Oesterhelt D PubMed
Mar 2006 Volume: 357 Issue: 3 Pages: 842-57

Parameters affecting the X-ray dose absorbed by macromolecular crystals.
Journal of synchrotron radiation
Murray JW, Rudiño-Piñera E, Owen RL, Grininger M, Ravelli RB, Garman EF PubMed
May 2005 Volume: 12 Issue: Pt 3 Pages: 268-75

Expression, crystallization and crystallographic analysis of DegS, a stress sensor of the bacterial periplasm.
Acta crystallographica. Section D, Biological crystallography
Grininger M, Ravelli RB, Heider U, Zeth K PubMed
Aug 2004 Volume: 60 Issue: Pt 8 Pages: 1429-31