Research Groups

 

Publications of Martin Grininger (Results: 63)

 

The Kinetics of Carbon-Carbon Bond Formation in Metazoan Fatty Acid Synthase and Its Impact on Product Fidelity.
Angewandte Chemie (International ed. in English)
Gusenda C, Calixto AR, Da Silva JR, Fernandes PA, Grininger M PubMed
Nov 2024 Volume: Issue: Pages: e202412195

The malonyl/acetyl-transferase from murine fatty acid synthase is a promiscuous engineering tool for editing polyketide scaffolds.
Communications chemistry
Buyachuihan L, Reiners S, Zhao Y, Grininger M PubMed
Aug 2024 Volume: 7 Issue: 1 Pages: 187

VitroJet: new features and case studies.
Acta crystallographica. Section D, Structural biology
Henderikx RJM, Mann D, Domanska A, Dong J, Shahzad S, Lak B, Filopoulou A, Ludig D, Grininger M, Momoh J, Laanto E, Oksanen HM, Bisikalo K, Williams PA, Butcher SJ, Peters PJ, Beulen BWAMM PubMed
Apr 2024 Volume: 80 Issue: Pt 4 Pages: 232-246

Direct structural analysis of a single acyl carrier protein domain in fatty acid synthase from the fungus Saccharomyces cerevisiae.
Communications biology
Samani EK, Chen AC, Lou JW, Dai DL, Keszei AFA, Tan G, Boone C, Grininger M, Mazhab-Jafari MT PubMed
Jan 2024 Volume: 7 Issue: 1 Pages: 92

How Acyl Carrier Proteins (ACPs) Direct Fatty Acid and Polyketide Biosynthesis.
Angewandte Chemie (International ed. in English)
Buyachuihan L, Stegemann F, Grininger M PubMed
Jan 2024 Volume: 63 Issue: 4 Pages: e202312476

CryoEM analysis of the essential native UDP-glucose pyrophosphorylase from reveals key conformations for activity regulation and function.
mBio
Han X, D'Angelo C, Otamendi A, Cifuente JO, de Astigarraga E, Ochoa-Lizarralde B, Grininger M, Routier FH, Guerin ME, Fuehring J, Etxebeste O, Connell SR PubMed
Aug 2023 Volume: 14 Issue: 4 Pages: e0041423

Docking Domain Engineering in a Modular Polyketide Synthase and Its Impact on Structure and Function.
ACS chemical biology
Buyachuihan L, Zhao Y, Schelhas C, Grininger M PubMed
Jul 2023 Volume: 18 Issue: 7 Pages: 1500-1509

Enzymology of assembly line synthesis by modular polyketide synthases.
Nature chemical biology
Grininger M PubMed
Apr 2023 Volume: 19 Issue: 4 Pages: 401-415

Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast.
Proceedings of the National Academy of Sciences of the United States of America
Zhai X, Gao J, Li Y, Grininger M, Zhou YJ PubMed
Mar 2023 Volume: 120 Issue: 12 Pages: e2220816120

Chemoenzymatic synthesis of fluorinated polyketides.
Nature chemistry
Rittner A, Joppe M, Schmidt JJ, Mayer LM, Reiners S, Heid E, Herzberg D, Sherman DH, Grininger M PubMed
Sep 2022 Volume: 14 Issue: 9 Pages: 1000-1006

Pathway and protein engineering for biosynthesis.
Synthetic and systems biotechnology
Zhou Y, Grininger M, Alper H PubMed
Dec 2022 Volume: 7 Issue: 4 Pages: 1044-1045

Structural insights into the mechanism of archaellar rotational switching.
Nature communications
Altegoer F, Quax TEF, Weiland P, Nußbaum P, Giammarinaro PI, Patro M, Li Z, Oesterhelt D, Grininger M, Albers SV, Bange G PubMed
May 2022 Volume: 13 Issue: 1 Pages: 2857

Solution Structure and Conformational Flexibility of a Polyketide Synthase Module.
JACS Au
Klaus M, Rossini E, Linden A, Paithankar KS, Zeug M, Ignatova Z, Urlaub H, Khosla C, Köfinger J, Hummer G, Grininger M PubMed
Dec 2021 Volume: 1 Issue: 12 Pages: 2162-2171

Correction: Engineering strategies for rational polyketide synthase design.
Natural product reports
Klaus M, Grininger M PubMed
Jul 2021 Volume: 38 Issue: 7 Pages: 1409

[Not Available].
Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)
Bourdeaux F, Rittner A, Grininger M PubMed
2021 Volume: 27 Issue: 3 Pages: 250-253

Cell-Free Synthesis of Natural Compounds from Genomic DNA of Biosynthetic Gene Clusters.
ACS synthetic biology
Siebels I, Nowak S, Heil CS, Tufar P, Cortina NS, Bode HB, Grininger M PubMed
Sep 2020 Volume: 9 Issue: 9 Pages: 2418-2426

Ketosynthase Domain Constrains the Design of Polyketide Synthases.
ACS chemical biology
Klaus M, Buyachuihan L, Grininger M PubMed
Sep 2020 Volume: 15 Issue: 9 Pages: 2422-2432

Dodecin as carrier protein for immunizations and bioengineering applications.
Scientific reports
Bourdeaux F, Kopp Y, Lautenschläger J, Gößner I, Besir H, Vabulas RM, Grininger M PubMed
Aug 2020 Volume: 10 Issue: 1 Pages: 13297

Smart Molecular Nanosheets for Advanced Preparation of Biological Samples in Electron Cryo-Microscopy.
ACS nano
Scherr J, Tang Z, Küllmer M, Balser S, Scholz AS, Winter A, Parey K, Rittner A, Grininger M, Zickermann V, Rhinow D, Terfort A, Turchanin A PubMed
Aug 2020 Volume: 14 Issue: 8 Pages: 9972-9978

Substrate promiscuity of polyketide synthase enables production of tsetse fly attractants 3-ethylphenol and 3-propylphenol by engineering precursor supply in yeast.
Scientific reports
Hitschler J, Grininger M, Boles E PubMed
Jun 2020 Volume: 10 Issue: 1 Pages: 9962

Fusing α and β subunits of the fungal fatty acid synthase leads to improved production of fatty acids.
Scientific reports
Wernig F, Born S, Boles E, Grininger M, Oreb M PubMed
Jun 2020 Volume: 10 Issue: 1 Pages: 9780

The role of the iterative modules in polyketide synthase evolution.
Proceedings of the National Academy of Sciences of the United States of America
Grininger M PubMed
Apr 2020 Volume: 117 Issue: 16 Pages: 8680-8682

The resolution revolution in cryoEM requires high-quality sample preparation: a rapid pipeline to a high-resolution map of yeast fatty acid synthase.
IUCrJ
Joppe M, D'Imprima E, Salustros N, Paithankar KS, Vonck J, Grininger M, Kühlbrandt W PubMed
Mar 2020 Volume: 7 Issue: Pt 2 Pages: 220-227

Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS).
Scientific reports
Fischer M, Joppe M, Mulinacci B, Vollrath R, Konstantinidis K, Kötter P, Ciccarelli L, Vonck J, Oesterhelt D, Grininger M PubMed
Jan 2020 Volume: 10 Issue: 1 Pages: 895

Type I fatty acid synthase trapped in the octanoyl-bound state.
Protein science : a publication of the Protein Society
Rittner A, Paithankar KS, Himmler A, Grininger M PubMed
Feb 2020 Volume: 29 Issue: 2 Pages: 589-605

Structure of the archaeal chemotaxis protein CheY in a domain-swapped dimeric conformation.
Acta crystallographica. Section F, Structural biology communications
Paithankar KS, Enderle M, Wirthensohn DC, Miller A, Schlesner M, Pfeiffer F, Rittner A, Grininger M, Oesterhelt D PubMed
Sep 2019 Volume: 75 Issue: Pt 9 Pages: 576-585

Comparative biochemical and structural analysis of the flavin-binding dodecins from and reveals striking differences with regard to multimerization.
Microbiology (Reading, England)
Bourdeaux F, Ludwig P, Paithankar K, Sander B, Essen LO, Grininger M, Mack M PubMed
Oct 2019 Volume: 165 Issue: 10 Pages: 1095-1106

Protein denaturation at the air-water interface and how to prevent it.
eLife
D'Imprima E, Floris D, Joppe M, Sánchez R, Grininger M, Kühlbrandt W PubMed
Apr 2019 Volume: 8 Issue: Pages:

Fatty Acid Biosynthesis: Chain-Length Regulation and Control.
Chembiochem : a European journal of chemical biology
Heil CS, Wehrheim SS, Paithankar KS, Grininger M PubMed
Sep 2019 Volume: 20 Issue: 18 Pages: 2298-2321

Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains.
ACS chemical biology
Klaus M, D'Souza AD, Nivina A, Khosla C, Grininger M PubMed
Mar 2019 Volume: 14 Issue: 3 Pages: 426-433

Probing the modularity of megasynthases by rational engineering of a fatty acid synthase Type I.
Protein science : a publication of the Protein Society
Rittner A, Paithankar KS, Drexler DJ, Himmler A, Grininger M PubMed
Feb 2019 Volume: 28 Issue: 2 Pages: 414-428

Site-Specific Labelling of Multidomain Proteins by Amber Codon Suppression.
Scientific reports
Heil CS, Rittner A, Goebel B, Beyer D, Grininger M PubMed
Oct 2018 Volume: 8 Issue: 1 Pages: 14864

Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs).
Chemical communications (Cambridge, England)
Rossini E, Gajewski J, Klaus M, Hummer G, Grininger M PubMed
Oct 2018 Volume: 54 Issue: 82 Pages: 11606-11609

Engineering strategies for rational polyketide synthase design.
Natural product reports
Klaus M, Grininger M PubMed
Oct 2018 Volume: 35 Issue: 10 Pages: 1070-1081

An engineered fatty acid synthase combined with a carboxylic acid reductase enables de novo production of 1-octanol in .
Biotechnology for biofuels
Henritzi S, Fischer M, Grininger M, Oreb M, Boles E PubMed
2018 Volume: 11 Issue: Pages: 150

Characterization of the small flavin-binding dodecin in the roseoflavin producer Streptomyces davawensis.
Microbiology (Reading, England)
Ludwig P, Sévin DC, Busche T, Kalinowski J, Bourdeaux F, Grininger M, Mack M PubMed
Jun 2018 Volume: 164 Issue: 6 Pages: 908-919

Flavin Storage and Sequestration by Mycobacterium tuberculosis Dodecin.
ACS infectious diseases
Bourdeaux F, Hammer CA, Vogt S, Schweighöfer F, Nöll G, Wachtveitl J, Grininger M PubMed
Jul 2018 Volume: 4 Issue: 7 Pages: 1082-1092

Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering.
ACS chemical biology
Rittner A, Paithankar KS, Huu KV, Grininger M PubMed
Mar 2018 Volume: 13 Issue: 3 Pages: 723-732

Strategies in megasynthase engineering - fatty acid synthases (FAS) as model proteins.
Beilstein journal of organic chemistry
Fischer M, Grininger M PubMed
2017 Volume: 13 Issue: Pages: 1204-1211

Engineering fungal de novo fatty acid synthesis for short chain fatty acid production.
Nature communications
Gajewski J, Pavlovic R, Fischer M, Boles E, Grininger M PubMed
Mar 2017 Volume: 8 Issue: Pages: 14650

Engineering fatty acid synthases for directed polyketide production.
Nature chemical biology
Gajewski J, Buelens F, Serdjukow S, Janßen M, Cortina N, Grubmüller H, Grininger M PubMed
Apr 2017 Volume: 13 Issue: 4 Pages: 363-365

Expanding the product portfolio of fungal type I fatty acid synthases.
Nature chemical biology
Zhu Z, Zhou YJ, Krivoruchko A, Grininger M, Zhao ZK, Nielsen J PubMed
Apr 2017 Volume: 13 Issue: 4 Pages: 360-362

Crystallization and X-ray diffraction studies of a complete bacterial fatty-acid synthase type I.
Acta crystallographica. Section F, Structural biology communications
Enderle M, McCarthy A, Paithankar KS, Grininger M PubMed
Nov 2015 Volume: 71 Issue: Pt 11 Pages: 1401-7

Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS.
Protein science : a publication of the Protein Society
Fischer M, Rhinow D, Zhu Z, Mills DJ, Zhao ZK, Vonck J, Grininger M PubMed
Jun 2015 Volume: 24 Issue: 6 Pages: 987-95

Multi-Ligand-Binding Flavoprotein Dodecin as a Key Element for Reversible Surface Modification in Nano-biotechnology.
ACS nano
Gutiérrez Sánchez C, Su Q, Schönherr H, Grininger M, Nöll G PubMed
2015 Volume: 9 Issue: 4 Pages: 3491-500

Modular polyketide synthases (PKSs): a new model fits all?
Chembiochem : a European journal of chemical biology
Rittner A, Grininger M PubMed
Nov 2014 Volume: 15 Issue: 17 Pages: 2489-93

Perspectives on the evolution, assembly and conformational dynamics of fatty acid synthase type I (FAS I) systems.
Current opinion in structural biology
Grininger M PubMed
Apr 2014 Volume: 25 Issue: Pages: 49-56

Directed manipulation of a flavoprotein photocycle.
Angewandte Chemie (International ed. in English)
Staudt H, Hoesl MG, Dreuw A, Serdjukow S, Oesterhelt D, Budisa N, Wachtveitl J, Grininger M PubMed
Aug 2013 Volume: 52 Issue: 32 Pages: 8463-6

Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex.
Structure (London, England : 1993)
Ciccarelli L, Connell SR, Enderle M, Mills DJ, Vonck J, Grininger M PubMed
Jul 2013 Volume: 21 Issue: 7 Pages: 1251-7

The flavoprotein dodecin as a redox probe for electron transfer through DNA.
Angewandte Chemie (International ed. in English)
Yu Y, Heidel B, Parapugna TL, Wenderhold-Reeb S, Song B, Schönherr H, Grininger M, Nöll G PubMed
Apr 2013 Volume: 52 Issue: 18 Pages: 4950-3

Ultrafast excited-state deactivation of flavins bound to dodecin.
The Journal of biological chemistry
Staudt H, Oesterhelt D, Grininger M, Wachtveitl J PubMed
May 2012 Volume: 287 Issue: 21 Pages: 17637-17644

Mechanism of substrate shuttling by the acyl-carrier protein within the fatty acid mega-synthase.
Journal of the American Chemical Society
Anselmi C, Grininger M, Gipson P, Faraldo-Gómez JD PubMed
Sep 2010 Volume: 132 Issue: 35 Pages: 12357-64

Structural and biochemical characterization of a halophilic archaeal alkaline phosphatase.
Journal of molecular biology
Wende A, Johansson P, Vollrath R, Dyall-Smith M, Oesterhelt D, Grininger M PubMed
Jul 2010 Volume: 400 Issue: 1 Pages: 52-62

Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy.
Proceedings of the National Academy of Sciences of the United States of America
Gipson P, Mills DJ, Wouts R, Grininger M, Vonck J, Kühlbrandt W PubMed
May 2010 Volume: 107 Issue: 20 Pages: 9164-9

Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase.
Structure (London, England : 1993)
Johansson P, Mulinacci B, Koestler C, Vollrath R, Oesterhelt D, Grininger M PubMed
Aug 2009 Volume: 17 Issue: 8 Pages: 1063-74

Blue-light-triggered photorelease of active chemicals captured by the flavoprotein dodecin.
Chembiochem : a European journal of chemical biology
Nöll G, Trawöger S, von Sanden-Flohe M, Dick B, Grininger M PubMed
Mar 2009 Volume: 10 Issue: 5 Pages: 834-7

Dodecin is the key player in flavin homeostasis of archaea.
The Journal of biological chemistry
Grininger M, Staudt H, Johansson P, Wachtveitl J, Oesterhelt D PubMed
May 2009 Volume: 284 Issue: 19 Pages: 13068-76

Electrochemical switching of the flavoprotein dodecin at gold surfaces modified by flavin-DNA hybrid linkers.
Biointerphases
Grininger M, Nöll G, Trawöger S, Sinner EK, Oesterhelt D PubMed
Sep 2008 Volume: 3 Issue: 3 Pages: 51-8

Inhibition of the fungal fatty acid synthase type I multienzyme complex.
Proceedings of the National Academy of Sciences of the United States of America
Johansson P, Wiltschi B, Kumari P, Kessler B, Vonrhein C, Vonck J, Oesterhelt D, Grininger M PubMed
Sep 2008 Volume: 105 Issue: 35 Pages: 12803-8

Dodecin sequesters FAD in closed conformation from the aqueous solution.
Journal of molecular biology
Grininger M, Seiler F, Zeth K, Oesterhelt D PubMed
Dec 2006 Volume: 364 Issue: 4 Pages: 561-6

Dodecins: a family of lumichrome binding proteins.
Journal of molecular biology
Grininger M, Zeth K, Oesterhelt D PubMed
Mar 2006 Volume: 357 Issue: 3 Pages: 842-57

Parameters affecting the X-ray dose absorbed by macromolecular crystals.
Journal of synchrotron radiation
Murray JW, Rudiño-Piñera E, Owen RL, Grininger M, Ravelli RB, Garman EF PubMed
May 2005 Volume: 12 Issue: Pt 3 Pages: 268-75

Expression, crystallization and crystallographic analysis of DegS, a stress sensor of the bacterial periplasm.
Acta crystallographica. Section D, Biological crystallography
Grininger M, Ravelli RB, Heider U, Zeth K PubMed
Aug 2004 Volume: 60 Issue: Pt 8 Pages: 1429-31