Research Groups

 

Non-catalytic kinase functions

Students ALWAYS welcome – please apply here for Bachelor / Master / PhD theses!

 

Sebastian Mathea

 

Sebastian Mathea is obsessed with protein structures, no matter whether it’s about catalytic mechanisms, substrate recognition or inhibitor binding modes.

 

 

Franziska Preuss

 

Franziska Preuss is the rising star in the pseudokinase field. Gotta solve 'em all! In the end, there'll be a pattern, hopefully.

 

 

Deep Chatterjee

 

Deep Chatterjee is the 'King of Insect Cells'. His way of making challenging proteins is unexcelled in terms of yield and purity.

 

 

Biochemical Journal - Lessons from LIMK1

Latest results on LIMK1:

  • Potential drug target to prevent #ALS and #FXS

  • ‘Rock-and-poke’ mechanism of catalysis

  • Docking sites for conventional & allosteric inhibitors
Full publication.

Expanded panel of active DUBs across the different enzyme subfamilies

 

This is from collaboration with Benedikt Kessler's lab in Oxford. Profiling active DUBs in cells with a mass spec proteomics approach. We contributed making the ubiquitin probe! Full publication.

Cover: High-Throughput Protein Production and Purification

 

We just published a method paper about how to make recombinant protein kinases PMID 31267453.