Research Groups

 

Non-catalytic kinase functions

Please follow us on Twitter @ChasingKinases

Students ALWAYS welcome – please apply here for Bachelor / Master / PhD theses!

 

Sebastian Mathea

 

Sebastian Mathea is obsessed with protein structures, no matter whether it’s about catalytic mechanisms, substrate recognition or inhibitor binding modes.

 

 

Franziska Preuss

 

Franziska Preuss is the rising star in the pseudokinase field. Gotta solve 'em all! In the end, there'll be a pattern, hopefully.

 

 

Deep Chatterjee

 

Deep Chatterjee is the 'King of Insect Cells'. His way of making challenging proteins is unexcelled in terms of yield and purity.

 

 

Verena Dederer

 

No fear of giant kinases! Verena Dederer applies high-throughput cloning to get hold of them.

 

 

 

Conformational plasticity of the ULK3 kinase domain

Conformational plasticity of the ULK3 kinase domain

Thank you so much for the fantastic collaboration @thesgcfrankfurt @CynthiaTallant @chatterjeedeep @BenediktKessler!

This is major progress in understanding Parkinson's disease biology!

This is major progress in understanding Parkinson's disease biology!

  • LRRK2 atomic resolution cryoEM structure
  • Switch between active / inactive conformations
  • Role of disease mutants
  • LRRK2 blocks cargo transport along microtubules
Full publication
Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4

 

Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4


Full publication
Molecular Cell - Wnt-binding receptor tyrosine kinases

Latest Pseudokinase News:

  • PTK7 ROR1 ROR2 RYK
  • Significance in cancer
  • Structures and dynamics
  • Small-molecule binders
Fantastic collaboration with Lemmon_lab Ungureanu_lab Radhakrishnan_lab


Full publication

Biochemical Journal - Lessons from LIMK1

Latest results on LIMK1:

  • Potential drug target to prevent #ALS and #FXS

  • ‘Rock-and-poke’ mechanism of catalysis

  • Docking sites for conventional & allosteric inhibitors
Full publication

Expanded panel of active DUBs across the different enzyme subfamilies

 

This is from collaboration with Benedikt Kessler's lab in Oxford. Profiling active DUBs in cells with a mass spec proteomics approach. We contributed making the ubiquitin probe!

Full publication




Cover: High-Throughput Protein Production and Purification

 

We just published a method paper about how to make recombinant protein kinases PMID 31267453.