Non-catalytic kinase functions
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Sebastian Mathea is obsessed with protein structures, no matter whether it’s about catalytic mechanisms, substrate recognition or inhibitor binding modes.
Franziska Preuss is the rising star in the pseudokinase field. Gotta solve 'em all! In the end, there'll be a pattern, hopefully.
Deep Chatterjee is the 'King of Insect Cells'. His way of making challenging proteins is unexcelled in terms of yield and purity.
No fear of giant kinases! Verena Dederer applies high-throughput cloning to get hold of them.
This review touches everything from structural dynamics to inhibitor development. Thanks everyone - was fun to discuss & write this together!
Conformational plasticity of the ULK3 kinase domain
Thank you so much for the fantastic collaboration @thesgcfrankfurt @CynthiaTallant @chatterjeedeep @BenediktKessler!
This is major progress in understanding Parkinson's disease biology!
- LRRK2 atomic resolution cryoEM structure
- Switch between active / inactive conformations
- Role of disease mutants
- LRRK2 blocks cargo transport along microtubules
Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4
Latest Pseudokinase News:
- PTK7 ROR1 ROR2 RYK
- Significance in cancer
- Structures and dynamics
- Small-molecule binders
Latest results on LIMK1:
- Potential drug target to prevent #ALS and #FXS
- ‘Rock-and-poke’ mechanism of catalysis
- Docking sites for conventional & allosteric inhibitors
This is from collaboration with Benedikt Kessler's lab in Oxford. Profiling active DUBs in cells with a mass spec proteomics approach. We contributed making the ubiquitin probe!
We just published a method paper about how to make recombinant protein kinases PMID 31267453.