Research Groups

 

Publications of Ivan Dikic (Results: 205)

 

Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.
Molecular cell
Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM PubMed
May 2017 Volume: 66 Issue: 4 Pages: 517-532.e9

Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation.
Nature microbiology
van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I PubMed
May 2017 Volume: 2 Issue: Pages: 17066

Proteasomal and Autophagy Degradation Systems.
Annual review of biochemistry
Dikic I PubMed
May 2017 Volume: Issue: Pages:

Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins.
Scientific reports
Rogov VV, Suzuki H, Marinković M, Lang V, Kato R, Kawasaki M, Buljubašić M, Šprung M, Rogova N, Wakatsuki S, Hamacher-Brady A, Dötsch V, Dikic I, Brady NR, Novak I PubMed
Apr 2017 Volume: 7 Issue: 1 Pages: 1131

Flow Cytometer Monitoring of Bnip3- and Bnip3L/Nix-Dependent Mitophagy.
Methods in molecular biology (Clifton, N.J.)
Šprung M, Dikic I, Novak I PubMed
Mar 2017 Volume: Issue: Pages:

Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.
Cell research
Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R PubMed
May 2017 Volume: 27 Issue: 5 Pages: 657-674

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator.
eLife
Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Müller S, Dikic I, Mittelbronn M, Behrends C PubMed
Feb 2017 Volume: 6 Issue: Pages:

Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.
Nature communications
Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I PubMed
Jan 2017 Volume: 8 Issue: Pages: 14004

IKKα controls ATG16L1 degradation to prevent ER stress during inflammation.
The Journal of experimental medicine
Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR PubMed
Feb 2017 Volume: 214 Issue: 2 Pages: 423-437

Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.
The EMBO journal
Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I PubMed
Feb 2017 Volume: 36 Issue: 4 Pages: 549-564

Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination.
Cell
Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, Dikic I PubMed
Dec 2016 Volume: 167 Issue: 6 Pages: 1636-1649.e13

Autophagy Captures the Nobel Prize.
Cell
Tooze SA, Dikic I PubMed
Dec 2016 Volume: 167 Issue: 6 Pages: 1433-1435

In Silico Knockout Studies of Xenophagic Capturing of Salmonella.
PLoS computational biology
Scheidel J, Amstein L, Ackermann J, Dikic I, Koch I PubMed
Dec 2016 Volume: 12 Issue: 12 Pages: e1005200

Removing the waste bags: how p97 drives autophagy of lysosomes.
The EMBO journal
Seczynska M, Dikic I PubMed
Jan 2017 Volume: 36 Issue: 2 Pages: 129-131

SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks.
eLife
Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I PubMed
Nov 2016 Volume: 5 Issue: Pages:

How the proteasome is degraded.
Proceedings of the National Academy of Sciences of the United States of America
Hoeller D, Dikic I PubMed
Nov 2016 Volume: 113 Issue: 47 Pages: 13266-13268

CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes.
Diabetes
Teng B, Schroder P, Müller-Deile J, Schenk H, Staggs L, Tossidou I, Dikic I, Haller H, Schiffer M PubMed
Dec 2016 Volume: 65 Issue: 12 Pages: 3667-3679

Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Trends in molecular medicine
Weishaupt JH, Hyman T, Dikic I PubMed
Sep 2016 Volume: 22 Issue: 9 Pages: 769-83

Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection.
Molecular cell
Fiskin E, Bionda T, Dikic I, Behrends C PubMed
Jun 2016 Volume: 62 Issue: 6 Pages: 967-81

Cell biology: Ubiquitination without E1 and E2 enzymes.
Nature
Bhogaraju S, Dikic I PubMed
May 2016 Volume: 533 Issue: 7601 Pages: 43-4

A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1.
The FEBS journal
Suzuki N, Rohaim A, Kato R, Dikic I, Wakatsuki S, Kawasaki M PubMed
Jun 2016 Volume: 283 Issue: 11 Pages: 2004-17

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.
Proceedings of the National Academy of Sciences of the United States of America
Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I PubMed
Apr 2016 Volume: 113 Issue: 15 Pages: 4039-44

Editorial overview: Cell regulation.
Current opinion in cell biology
Baccarini M, Dikic I PubMed
Apr 2016 Volume: 39 Issue: Pages: iv-vi

An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis.
The American journal of pathology
Nastase MV, Zeng-Brouwers J, Frey H, Hsieh LT, Poluzzi C, Beckmann J, Schroeder N, Pfeilschifter J, Lopez-Mosqueda J, Mersmann J, Ikeda F, Iozzo RV, Dikic I, Schaefer L PubMed
May 2016 Volume: 186 Issue: 5 Pages: 1206-20

Bacteria-host relationship: ubiquitin ligases as weapons of invasion.
Cell research
Maculins T, Fiskin E, Bhogaraju S, Dikic I PubMed
Apr 2016 Volume: 26 Issue: 4 Pages: 499-510

Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
Oncotarget
Jennewein L, Ronellenfitsch MW, Antonietti P, Ilina EI, Jung J, Stadel D, Flohr LM, Zinke J, von Renesse J, Drott U, Baumgarten P, Braczynski AK, Penski C, Burger MC, Theurillat JP, Steinbach JP, Plate KH, Dikic I, Fulda S, Brandts C, Kögel D, Behrends C, Harter PN, Mittelbronn M PubMed
Apr 2016 Volume: 7 Issue: 15 Pages: 20016-32

Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation.
The Journal of biological chemistry
Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V PubMed
Apr 2016 Volume: 291 Issue: 17 Pages: 9025-41

SnapShot: Expanding the Ubiquitin Code.
Cell
Rajalingam K, Dikic I PubMed
Feb 2016 Volume: 164 Issue: 5 Pages: 1074-1074.e1

Ubiquitin chain diversity at a glance.
Journal of cell science
Akutsu M, Dikic I, Bremm A PubMed
Mar 2016 Volume: 129 Issue: 5 Pages: 875-80

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amad... PubMed
2016 Volume: 12 Issue: 1 Pages: 1-222

Autophagy and modular restructuring of metabolism control germline tumor differentiation and proliferation in C. elegans.
Autophagy
Gomes LC, Odedra D, Dikic I, Pohl C PubMed
2016 Volume: 12 Issue: 3 Pages: 529-46

The integration of autophagy and cellular trafficking pathways via RAB GAPs.
Autophagy
Kern A, Dikic I, Behl C PubMed
2015 Volume: 11 Issue: 12 Pages: 2393-7

Ubiquitin-Dependent And Independent Signals In Selective Autophagy.
Trends in cell biology
Khaminets A, Behl C, Dikic I PubMed
Jan 2016 Volume: 26 Issue: 1 Pages: 6-16

Expanding the ubiquitin code through post-translational modification.
EMBO reports
Herhaus L, Dikic I PubMed
Sep 2015 Volume: 16 Issue: 9 Pages: 1071-83

Binding of SGTA to Rpn13 selectively modulates protein quality control.
Journal of cell science
Leznicki P, Korac-Prlic J, Kliza K, Husnjak K, Nyathi Y, Dikic I, High S PubMed
Sep 2015 Volume: 128 Issue: 17 Pages: 3187-96

Regulation of endoplasmic reticulum turnover by selective autophagy.
Nature
Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I PubMed
Jun 2015 Volume: 522 Issue: 7556 Pages: 354-8

PLEKHM1: Adapting to life at the lysosome.
Autophagy
McEwan DG, Dikic I PubMed
Apr 2015 Volume: 11 Issue: 4 Pages: 720-2

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.
Nature neuroscience
Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz S, Boeckers TM, Meyer T, Winkler AS, Winkelman J, de Carvalho M, Thal DR, Otto M, Brännström T, Volk AE, Kursula P, Danzer KM, Lichtner P, Dikic I, Meitinger T, Ludolph AC, Strom TM, Andersen PM, Weishaupt JH PubMed
May 2015 Volume: 18 Issue: 5 Pages: 631-6

Cullins keep autophagy under control.
Developmental cell
McEwan DG, Dikic I PubMed
Dec 2014 Volume: 31 Issue: 6 Pages: 675-6

PINK1-PARKIN interplay: down to ubiquitin phosphorylation.
Molecular cell
Stolz A, Dikic I PubMed
Nov 2014 Volume: 56 Issue: 3 Pages: 341-2

PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.
Cell host & microbe
McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic I PubMed
Jan 2015 Volume: 17 Issue: 1 Pages: 58-71

PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.
Molecular cell
McEwan DG, Popovic D, Gubas A, Terawaki S, Suzuki H, Stadel D, Coxon FP, Miranda de Stegmann D, Bhogaraju S, Maddi K, Kirchof A, Gatti E, Helfrich MH, Wakatsuki S, Behrends C, Pierre P, Dikic I PubMed
Jan 2015 Volume: 57 Issue: 1 Pages: 39-54

RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy.
Autophagy
Spang N, Feldmann A, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, Koziollek-Drechsler I, Clement AM, Moosmann B, Jung J, Behrends C, Dikic I, Kern A, Behl C PubMed
2014 Volume: 10 Issue: 12 Pages: 2297-309

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.
eLife
Kumari S, Redouane Y, Lopez-Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, Kuiper J, Martinez C, Dikic I, Pasparakis M, Ikeda F PubMed
Dec 2014 Volume: 3 Issue: Pages:

Ubiquitination in disease pathogenesis and treatment.
Nature medicine
Popovic D, Vucic D, Dikic I PubMed
Nov 2014 Volume: 20 Issue: 11 Pages: 1242-53

DUBs counteract parkin for efficient mitophagy.
The EMBO journal
Dikic I, Bremm A PubMed
Nov 2014 Volume: 33 Issue: 21 Pages: 2442-3

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features.
Nature genetics
Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terzic I, Lopez-Mosqueda J, Philipp M, Sim JC, Smith KR, Oehler J, Cabrera E, Freire R, Pope K, Nahid A, Norris F, Leventer RJ, Delatycki MB, Barbi G, von Ameln S, Högel J, Degoricija M, Fertig R, Burkhalter MD, Hofmann K, Thiele H, Altmüller J, Nürnberg G, Nürnberg P, Bahlo M, Martin GM, Aalfs CM, Oshima J, Terzic J, Amor DJ, Dikic I, Ramadan K, Kubisch C PubMed
Nov 2014 Volume: 46 Issue: 11 Pages: 1239-44

A peek into the atomic details of thalidomide's clinical effects.
Nature structural & molecular biology
Bhogaraju S, Dikic I PubMed
Sep 2014 Volume: 21 Issue: 9 Pages: 739-40

Cargo recognition and trafficking in selective autophagy.
Nature cell biology
Stolz A, Ernst A, Dikic I PubMed
Jun 2014 Volume: 16 Issue: 6 Pages: 495-501

Deciphering functions of branched ubiquitin chains.
Cell
López-Mosqueda J, Dikic I PubMed
May 2014 Volume: 157 Issue: 4 Pages: 767-9

Autophagy in antimicrobial immunity.
Molecular cell
Gomes LC, Dikic I PubMed
Apr 2014 Volume: 54 Issue: 2 Pages: 224-33

Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling.
Molecular cell
Schaeffer V, Akutsu M, Olma MH, Gomes LC, Kawasaki M, Dikic I PubMed
May 2014 Volume: 54 Issue: 3 Pages: 349-61

Germline polymorphisms in RNF31 regulate linear ubiquitination and oncogenic signaling.
Cancer discovery
Grumati P, Dikic I PubMed
Apr 2014 Volume: 4 Issue: 4 Pages: 394-6

Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification.
Chemistry & biology
Tufar P, Rahighi S, Kraas FI, Kirchner DK, Löhr F, Henrich E, Köpke J, Dikic I, Güntert P, Marahiel MA, Dötsch V PubMed
Apr 2014 Volume: 21 Issue: 4 Pages: 552-62

TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy.
EMBO reports
Popovic D, Dikic I PubMed
Apr 2014 Volume: 15 Issue: 4 Pages: 392-401

The seven wonders of ubiquitin: a multi-interview: Personal insights into the ubiquitin field. Interview by Nonia Pariente.
EMBO reports
Dikic I, Harper W, Hay R, Langer T, Rape M, Sixma T, Walczak H PubMed
Jan 2014 Volume: 15 Issue: 1 Pages: 7-11

Ubiquitin-dependent sorting in endocytosis.
Cold Spring Harbor perspectives in biology
Piper RC, Dikic I, Lukacs GL PubMed
Jan 2014 Volume: 6 Issue: 1 Pages:

The LC3 interactome at a glance.
Journal of cell science
Wild P, McEwan DG, Dikic I PubMed
Jan 2014 Volume: 127 Issue: Pt 1 Pages: 3-9

Breaking the limits of artificial ubiquitination.
Proceedings of the National Academy of Sciences of the United States of America
Putyrski M, Dikic I PubMed
Oct 2013 Volume: 110 Issue: 44 Pages: 17606-7

Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
Nature
Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I, Rittinger K PubMed
Nov 2013 Volume: 503 Issue: 7476 Pages: 422-6

Selective monitoring of ubiquitin signals with genetically encoded ubiquitin chain-specific sensors.
Nature protocols
van Wijk SJ, Fiškin E, Dikic I PubMed
2013 Volume: 8 Issue: 7 Pages: 1449-58

Structural basis for phosphorylation-triggered autophagic clearance of Salmonella.
The Biochemical journal
Rogov VV, Suzuki H, Fiskin E, Wild P, Kniss A, Rozenknop A, Kato R, Kawasaki M, McEwan DG, Löhr F, Güntert P, Dikic I, Wakatsuki S, Dötsch V PubMed
Sep 2013 Volume: 454 Issue: 3 Pages: 459-66

The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy.
Developmental cell
Carroll B, Mohd-Naim N, Maximiano F, Frasa MA, McCormack J, Finelli M, Thoresen SB, Perdios L, Daigaku R, Francis RE, Futter C, Dikic I, Braga VM PubMed
Apr 2013 Volume: 25 Issue: 1 Pages: 15-28

Cullins getting undressed by the protein exchange factor Cand1.
Cell
Olma MH, Dikic I PubMed
Mar 2013 Volume: 153 Issue: 1 Pages: 14-6

Parkin promotes cell survival via linear ubiquitination.
The EMBO journal
Fiškin E, Dikic I PubMed
Apr 2013 Volume: 32 Issue: 8 Pages: 1072-4

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing.
Nature methods
Crosetto N, Mitra A, Silva MJ, Bienko M, Dojer N, Wang Q, Karaca E, Chiarle R, Skrzypczak M, Ginalski K, Pasero P, Rowicka M, Dikic I PubMed
Apr 2013 Volume: 10 Issue: 4 Pages: 361-5

Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis.
The Journal of biological chemistry
Zhu Y, Massen S, Terenzio M, Lang V, Chen-Lindner S, Eils R, Novak I, Dikic I, Hamacher-Brady A, Brady NR PubMed
Jan 2013 Volume: 288 Issue: 2 Pages: 1099-113

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates.
Journal of cell science
Korac J, Schaeffer V, Kovacevic I, Clement AM, Jungblut B, Behl C, Terzic J, Dikic I PubMed
Jan 2013 Volume: 126 Issue: Pt 2 Pages: 580-92

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7.
The EMBO journal
Verhelst K, Carpentier I, Kreike M, Meloni L, Verstrepen L, Kensche T, Dikic I, Beyaert R PubMed
Oct 2012 Volume: 31 Issue: 19 Pages: 3845-55

Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, A... PubMed
Apr 2012 Volume: 8 Issue: 4 Pages: 445-544

Fighting mycobacteria through ISGylation.
EMBO reports
Pohl C, Dikic I PubMed
Oct 2012 Volume: 13 Issue: 10 Pages: 872-3

Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex.
Cell host & microbe
Belgnaoui SM, Paz S, Samuel S, Goulet ML, Sun Q, Kikkert M, Iwai K, Dikic I, Hiscott J, Lin R PubMed
Aug 2012 Volume: 12 Issue: 2 Pages: 211-22

Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells.
Molecular cell
van Wijk SJ, Fiskin E, Putyrski M, Pampaloni F, Hou J, Wild P, Kensche T, Grecco HE, Bastiaens P, Dikic I PubMed
Sep 2012 Volume: 47 Issue: 5 Pages: 797-809

Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications.
EMBO molecular medicine
Fulda S, Rajalingam K, Dikic I PubMed
Jul 2012 Volume: 4 Issue: 7 Pages: 545-56

Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.
The Journal of biological chemistry
Kensche T, Tokunaga F, Ikeda F, Goto E, Iwai K, Dikic I PubMed
Jul 2012 Volume: 287 Issue: 28 Pages: 23626-34

Selectivity of the ubiquitin-binding modules.
FEBS letters
Rahighi S, Dikic I PubMed
Aug 2012 Volume: 586 Issue: 17 Pages: 2705-10

Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold.
The Journal of biological chemistry
Stieglitz B, Haire LF, Dikic I, Rittinger K PubMed
Jun 2012 Volume: 287 Issue: 25 Pages: 20823-9

Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions.
Annual review of biochemistry
Husnjak K, Dikic I PubMed
2012 Volume: 81 Issue: Pages: 291-322

A universal expression tag for structural and functional studies of proteins.
Chembiochem : a European journal of chemical biology
Rogov VV, Rozenknop A, Rogova NY, Löhr F, Tikole S, Jaravine V, Güntert P, Dikic I, Dötsch V PubMed
May 2012 Volume: 13 Issue: 7 Pages: 959-63

Generation and physiological roles of linear ubiquitin chains.
BMC biology
Walczak H, Iwai K, Dikic I PubMed
Mar 2012 Volume: 10 Issue: Pages: 23

Ubiquitin ligases and beyond.
BMC biology
Dikic I, Robertson M PubMed
Mar 2012 Volume: 10 Issue: Pages: 22

Ivan Dikic was trained as a medical doctor at the University of Zagreb, Croatia.
Current biology : CB
Dikic I PubMed
Feb 2012 Volume: 22 Issue: 3 Pages: R76-7

The role of ubiquitylation in receptor endocytosis and endosomal sorting.
Journal of cell science
Haglund K, Dikic I PubMed
Jan 2012 Volume: 125 Issue: Pt 2 Pages: 265-75

Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.
Molecular and cellular biology
Popovic D, Akutsu M, Novak I, Harper JW, Behrends C, Dikic I PubMed
May 2012 Volume: 32 Issue: 9 Pages: 1733-44

Signalling through the grapevine.
EMBO reports
Dikic I, Daly RJ PubMed
Mar 2012 Volume: 13 Issue: 3 Pages: 178-80

Role of UbL family modifiers and their binding proteins in cell signaling.
Methods in molecular biology (Clifton, N.J.)
van Wijk SJ, Bienko M, Dikic I PubMed
2012 Volume: 832 Issue: Pages: 163-71

Structure of a compact conformation of linear diubiquitin.
Acta crystallographica. Section D, Biological crystallography
Rohaim A, Kawasaki M, Kato R, Dikic I, Wakatsuki S PubMed
Feb 2012 Volume: 68 Issue: Pt 2 Pages: 102-8

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.
Nature cell biology
Sandilands E, Serrels B, McEwan DG, Morton JP, Macagno JP, McLeod K, Stevens C, Brunton VG, Langdon WY, Vidal M, Sansom OJ, Dikic I, Wilkinson S, Frame MC PubMed
Dec 2011 Volume: 14 Issue: 1 Pages: 51-60

Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair.
Genes & development
van Wijk SJ, Müller S, Dikic I PubMed
Sep 2011 Volume: 25 Issue: 17 Pages: 1763-9

Conformational flexibility and rotation of the RING domain in activation of cullin-RING ligases.
Nature structural & molecular biology
Rahighi S, Dikic I PubMed
Aug 2011 Volume: 18 Issue: 8 Pages: 863-5

Healthy ageing through regulated proteostasis.
The EMBO journal
Rajalingam K, Dikic I PubMed
Aug 2011 Volume: 30 Issue: 15 Pages: 2983-5

Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1.
Journal of molecular biology
Rozenknop A, Rogov VV, Rogova NY, Löhr F, Güntert P, Dikic I, Dötsch V PubMed
Jul 2011 Volume: 410 Issue: 3 Pages: 477-87

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.
Science (New York, N.Y.)
Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady NR, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D, Dikic I PubMed
Jul 2011 Volume: 333 Issue: 6039 Pages: 228-33

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
Nature
Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I PubMed
Mar 2011 Volume: 471 Issue: 7340 Pages: 637-41

The spatial and temporal organization of ubiquitin networks.
Nature reviews. Molecular cell biology
Grabbe C, Husnjak K, Dikic I PubMed
05 2011 Volume: 12 Issue: 5 Pages: 295-307

Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2.
Journal of cell science
Mendl N, Occhipinti A, Müller M, Wild P, Dikic I, Reichert AS PubMed
Apr 2011 Volume: 124 Issue: Pt 8 Pages: 1339-50

The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation.
Trends in cell biology
McEwan DG, Dikic I PubMed
Apr 2011 Volume: 21 Issue: 4 Pages: 195-201

Regulation of ubiquitin receptors by coupled monoubiquitination.
Sub-cellular biochemistry
Hoeller D, Dikic I PubMed
2010 Volume: 54 Issue: Pages: 31-40

Autophagy receptors in developmental clearance of mitochondria.
Autophagy
Novak I, Dikic I PubMed
Mar 2011 Volume: 7 Issue: 3 Pages: 301-3

Selective binding of linear ubiquitin chains to NEMO in NF-kappaB activation.
Advances in experimental medicine and biology
Ikeda F, Rahighi S, Wakatsuki S, Dikic I PubMed
2011 Volume: 691 Issue: Pages: 107-14

What determines the specificity and outcomes of ubiquitin signaling?
Cell
Ikeda F, Crosetto N, Dikic I PubMed
Nov 2010 Volume: 143 Issue: 5 Pages: 677-81

Ubiquitin networks in cancer.
Current opinion in genetics & development
Kirkin V, Dikic I PubMed
Feb 2011 Volume: 21 Issue: 1 Pages: 21-8

Crystallization of small proteins assisted by green fluorescent protein.
Acta crystallographica. Section D, Biological crystallography
Suzuki N, Hiraki M, Yamada Y, Matsugaki N, Igarashi N, Kato R, Dikic I, Drew D, Iwata S, Wakatsuki S, Kawasaki M PubMed
Oct 2010 Volume: 66 Issue: Pt 10 Pages: 1059-66

Spatial organization of transmembrane receptor signalling.
The EMBO journal
Bethani I, Skånland SS, Dikic I, Acker-Palmer A PubMed
Aug 2010 Volume: 29 Issue: 16 Pages: 2677-88

CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.
The EMBO journal
Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I PubMed
Jul 2010 Volume: 29 Issue: 14 Pages: 2421-32

Post-translational modifications in signal integration.
Nature structural & molecular biology
Deribe YL, Pawson T, Dikic I PubMed
Jun 2010 Volume: 17 Issue: 6 Pages: 666-72

Notch: Implications of endogenous inhibitors for therapy.
BioEssays : news and reviews in molecular, cellular and developmental biology
Dikic I, Schmidt MH PubMed
Jun 2010 Volume: 32 Issue: 6 Pages: 481-7

Not all autophagy membranes are created equal.
Cell
McEwan DG, Dikic I PubMed
May 2010 Volume: 141 Issue: 4 Pages: 564-6

Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster.
Current biology : CB
Haglund K, Nezis IP, Lemus D, Grabbe C, Wesche J, Liestøl K, Dikic I, Palmer R, Stenmark H PubMed
May 2010 Volume: 20 Issue: 10 Pages: 944-50

Selective autophagy in cancer development and therapy.
Cancer research
Dikic I, Johansen T, Kirkin V PubMed
May 2010 Volume: 70 Issue: 9 Pages: 3431-4

The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.
Proceedings of the National Academy of Sciences of the United States of America
Vivanco I, Rohle D, Versele M, Iwanami A, Kuga D, Oldrini B, Tanaka K, Dang J, Kubek S, Palaskas N, Hsueh T, Evans M, Mulholland D, Wolle D, Rajasekaran S, Rajasekaran A, Liau LM, Cloughesy TF, Dikic I, Brennan C, Wu H, Mischel PS, Perera T, Mellinghoff IK PubMed
Apr 2010 Volume: 107 Issue: 14 Pages: 6459-64

Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1.
Molecular cell
Bomar MG, D'Souza S, Bienko M, Dikic I, Walker GC, Zhou P PubMed
Feb 2010 Volume: 37 Issue: 3 Pages: 408-17

Regulation of translesion synthesis DNA polymerase eta by monoubiquitination.
Molecular cell
Bienko M, Green CM, Sabbioneda S, Crosetto N, Matic I, Hibbert RG, Begovic T, Niimi A, Mann M, Lehmann AR, Dikic I PubMed
Feb 2010 Volume: 37 Issue: 3 Pages: 396-407

Mitochondria get a Parkin' ticket.
Nature cell biology
Wild P, Dikic I PubMed
Feb 2010 Volume: 12 Issue: 2 Pages: 104-6

Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity.
Biological chemistry
Nagy V, Dikic I PubMed
Volume: 391 Issue: 2-3 Pages: 163-9

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.
Science signaling
Deribe YL, Wild P, Chandrashaker A, Curak J, Schmidt MH, Kalaidzidis Y, Milutinovic N, Kratchmarova I, Buerkle L, Fetchko MJ, Schmidt P, Kittanakom S, Brown KR, Jurisica I, Blagoev B, Zerial M, Stagljar I, Dikic I PubMed
Dec 2009 Volume: 2 Issue: 102 Pages: ra84

Nix is a selective autophagy receptor for mitochondrial clearance.
EMBO reports
Novak I, Kirkin V, McEwan DG, Zhang J, Wild P, Rozenknop A, Rogov V, Löhr F, Popovic D, Occhipinti A, Reichert AS, Terzic J, Dötsch V, Ney PA, Dikic I PubMed
Jan 2010 Volume: 11 Issue: 1 Pages: 45-51

Ubiquitin linkages make a difference.
Nature structural & molecular biology
Dikic I, Dötsch V PubMed
Dec 2009 Volume: 16 Issue: 12 Pages: 1209-10

Ubiquitin-binding domains - from structures to functions.
Nature reviews. Molecular cell biology
Dikic I, Wakatsuki S, Walters KJ PubMed
Oct 2009 Volume: 10 Issue: 10 Pages: 659-71

The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice.
PLoS genetics
Lappe-Siefke C, Loebrich S, Hevers W, Waidmann OB, Schweizer M, Fehr S, Fritschy JM, Dikic I, Eilers J, Wilson SM, Kneussel M PubMed
Sep 2009 Volume: 5 Issue: 9 Pages: e1000631

Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.
Nature cell biology
Schmidt MH, Bicker F, Nikolic I, Meister J, Babuke T, Picuric S, Müller-Esterl W, Plate KH, Dikic I PubMed
Jul 2009 Volume: 11 Issue: 7 Pages: 873-80

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets.
Cell cycle (Georgetown, Tex.)
Lamark T, Kirkin V, Dikic I, Johansen T PubMed
Jul 2009 Volume: 8 Issue: 13 Pages: 1986-90

A role for ubiquitin in selective autophagy.
Molecular cell
Kirkin V, McEwan DG, Novak I, Dikic I PubMed
May 2009 Volume: 34 Issue: 3 Pages: 259-69

NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets.
Autophagy
Kirkin V, Lamark T, Johansen T, Dikic I PubMed
Jul 2009 Volume: 5 Issue: 5 Pages: 732-3

Journal club. A new ubiquitin chain, a new signal.
Nature reviews. Molecular cell biology
Dikic I PubMed
May 2009 Volume: 10 Issue: 5 Pages: 306

Targeting the ubiquitin system in cancer therapy.
Nature
Hoeller D, Dikic I PubMed
Mar 2009 Volume: 458 Issue: 7237 Pages: 438-44

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.
Cell
Rahighi S, Ikeda F, Kawasaki M, Akutsu M, Suzuki N, Kato R, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki S, Dikic I PubMed
Mar 2009 Volume: 136 Issue: 6 Pages: 1098-109

Functional roles of ubiquitin-like domain (ULD) and ubiquitin-binding domain (UBD) containing proteins.
Chemical reviews
Grabbe C, Dikic I PubMed
Apr 2009 Volume: 109 Issue: 4 Pages: 1481-94

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
Molecular cell
Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T PubMed
Feb 2009 Volume: 33 Issue: 4 Pages: 505-16

Ubiquitin-binding motif of human DNA polymerase eta is required for correct localization.
Proceedings of the National Academy of Sciences of the United States of America
Sabbioneda S, Green CM, Bienko M, Kannouche P, Dikic I, Lehmann AR PubMed
Feb 2009 Volume: 106 Issue: 8 Pages: E20; author reply E21

Caspase-8 is involved in neovascularization-promoting progenitor cell functions.
Arteriosclerosis, thrombosis, and vascular biology
Scharner D, Rössig L, Carmona G, Chavakis E, Urbich C, Fischer A, Kang TB, Wallach D, Chiang YJ, Deribe YL, Dikic I, Zeiher AM, Dimmeler S PubMed
Apr 2009 Volume: 29 Issue: 4 Pages: 571-8

Inhibitors of apoptosis catch ubiquitin.
The Biochemical journal
Rajalingam K, Dikic I PubMed
Jan 2009 Volume: 417 Issue: 1 Pages: e1-3

Cell biology. Going global on ubiquitin.
Science (New York, N.Y.)
Grabbe C, Dikic I PubMed
Nov 2008 Volume: 322 Issue: 5903 Pages: 872-3

Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner.
The Journal of biological chemistry
Crosetto N, Bienko M, Hibbert RG, Perica T, Ambrogio C, Kensche T, Hofmann K, Sixma TK, Dikic I PubMed
Dec 2008 Volume: 283 Issue: 50 Pages: 35173-85

Reply to "The binding stoichiometry of CIN85 SH3 domain A and Cbl-b".
Nature structural & molecular biology
Jozic D, Cárdenes N, Deribe YL, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J PubMed
Sep 2008 Volume: 15 Issue: 9 Pages: 891-2

Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.
Cellular signalling
Nonis D, Schmidt MH, van de Loo S, Eich F, Dikic I, Nowock J, Auburger G PubMed
Oct 2008 Volume: 20 Issue: 10 Pages: 1725-39

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series.
EMBO reports
Ikeda F, Dikic I PubMed
Jun 2008 Volume: 9 Issue: 6 Pages: 536-42

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction.
Nature
Schreiner P, Chen X, Husnjak K, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters KJ, Groll M PubMed
May 2008 Volume: 453 Issue: 7194 Pages: 548-52

Proteasome subunit Rpn13 is a novel ubiquitin receptor.
Nature
Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D, Dikic I PubMed
May 2008 Volume: 453 Issue: 7194 Pages: 481-8

An ultrasensitive sorting mechanism for EGF receptor endocytosis.
BMC systems biology
Schmidt-Glenewinkel H, Vacheva I, Hoeller D, Dikic I, Eils R PubMed
Apr 2008 Volume: 2 Issue: Pages: 32

Childhood of a phoenix: modern biology in Eastern and South-Eastern Europe.
Nature reviews. Molecular cell biology
Zagrovic B, Dikic I PubMed
04 2008 Volume: 9 Issue: 4 Pages: 333-6

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation.
The EMBO journal
Iha H, Peloponese JM, Verstrepen L, Zapart G, Ikeda F, Smith CD, Starost MF, Yedavalli V, Heyninck K, Dikic I, Beyaert R, Jeang KT PubMed
Feb 2008 Volume: 27 Issue: 4 Pages: 629-41

Novel markers of normal and neoplastic human plasmacytoid dendritic cells.
Blood
Marafioti T, Paterson JC, Ballabio E, Reichard KK, Tedoldi S, Hollowood K, Dictor M, Hansmann ML, Pileri SA, Dyer MJ, Sozzani S, Dikic I, Shaw AS, Petrella T, Stein H, Isaacson PG, Facchetti F, Mason DY PubMed
Apr 2008 Volume: 111 Issue: 7 Pages: 3778-92

Signal processing by its coil zipper domain activates IKK gamma.
Proceedings of the National Academy of Sciences of the United States of America
Bloor S, Ryzhakov G, Wagner S, Butler PJ, Smith DL, Krumbach R, Dikic I, Randow F PubMed
Jan 2008 Volume: 105 Issue: 4 Pages: 1279-84

Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance.
The Journal of biological chemistry
Guo C, Tang TS, Bienko M, Dikic I, Friedberg EC PubMed
Feb 2008 Volume: 283 Issue: 8 Pages: 4658-64

Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases.
FEBS letters
Raguz J, Wagner S, Dikic I, Hoeller D PubMed
Oct 2007 Volume: 581 Issue: 24 Pages: 4767-72

Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.
The EMBO journal
Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dötsch V, Dikic I PubMed
Jul 2007 Volume: 26 Issue: 14 Pages: 3451-62

E3-independent monoubiquitination of ubiquitin-binding proteins.
Molecular cell
Hoeller D, Hecker CM, Wagner S, Rogov V, Dötsch V, Dikic I PubMed
Jun 2007 Volume: 26 Issue: 6 Pages: 891-8

Malfunctions within the Cbl interactome uncouple receptor tyrosine kinases from destructive transport.
European journal of cell biology
Dikic I, Schmidt MH PubMed
Sep 2007 Volume: 86 Issue: 9 Pages: 505-12

Flt3-dependent transformation by inactivating c-Cbl mutations in AML.
Blood
Sargin B, Choudhary C, Crosetto N, Schmidt MH, Grundler R, Rensinghoff M, Thiessen C, Tickenbrock L, Schwäble J, Brandts C, August B, Koschmieder S, Bandi SR, Duyster J, Berdel WE, Müller-Tidow C, Dikic I, Serve H PubMed
Aug 2007 Volume: 110 Issue: 3 Pages: 1004-12

Role of ubiquitin- and Ubl-binding proteins in cell signaling.
Current opinion in cell biology
Kirkin V, Dikic I PubMed
Apr 2007 Volume: 19 Issue: 2 Pages: 199-205

Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase η in Saccharomyces cerevisiae.
Nucleic acids research
Parker JL, Bielen AB, Dikic I, Ulrich HD PubMed
Feb 2007 Volume: 35 Issue: 3 Pages: 881-889

Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae.
Nucleic acids research
Parker JL, Bielen AB, Dikic I, Ulrich HD PubMed
2007 Volume: 35 Issue: 3 Pages: 881-9

CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes.
The Journal of biological chemistry
Tossidou I, Kardinal C, Peters I, Kriz W, Shaw A, Dikic I, Tkachuk S, Dumler I, Haller H, Schiffer M PubMed
Mar 2007 Volume: 282 Issue: 10 Pages: 7457-64

Ubiquitin hubs in oncogenic networks.
Molecular cancer research : MCR
Crosetto N, Bienko M, Dikic I PubMed
Dec 2006 Volume: 4 Issue: 12 Pages: 899-904

Ubiquitin and NEDD8: brothers in arms.
Science's STKE : signal transduction knowledge environment
Schmidt MH, Dikic I PubMed
Nov 2006 Volume: 2006 Issue: 362 Pages: pe50

Targeting ubiquitin in cancers.
European journal of cancer (Oxford, England : 1990)
Dikic I, Crosetto N, Calatroni S, Bernasconi P PubMed
Dec 2006 Volume: 42 Issue: 18 Pages: 3095-102

Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain.
The Journal of biological chemistry
Moncalián G, Cárdenes N, Deribe YL, Spínola-Amilibia M, Dikic I, Bravo J PubMed
Dec 2006 Volume: 281 Issue: 50 Pages: 38845-53

Ubiquitin and ubiquitin-like proteins in cancer pathogenesis.
Nature reviews. Cancer
Hoeller D, Hecker CM, Dikic I PubMed
Oct 2006 Volume: 6 Issue: 10 Pages: 776-88

Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage.
Molecular and cellular biology
Guo C, Tang TS, Bienko M, Parker JL, Bielen AB, Sonoda E, Takeda S, Ulrich HD, Dikic I, Friedberg EC PubMed
Dec 2006 Volume: 26 Issue: 23 Pages: 8892-900

EGFR trafficking: parkin' in a jam.
Nature cell biology
Husnjak K, Dikic I PubMed
Aug 2006 Volume: 8 Issue: 8 Pages: 787-8

Reading protein modifications with interaction domains.
Nature reviews. Molecular cell biology
Seet BT, Dikic I, Zhou MM, Pawson T PubMed
Jul 2006 Volume: 7 Issue: 7 Pages: 473-83

Assays to monitor degradation of the EGF receptor.
Methods in molecular biology (Clifton, N.J.)
Schmidt MH, Dikic I PubMed
2006 Volume: 327 Issue: Pages: 131-8

CYLD in ubiquitin signaling and tumor pathogenesis.
Cell
Ikeda F, Dikic I PubMed
May 2006 Volume: 125 Issue: 4 Pages: 643-5

Specification of SUMO1- and SUMO2-interacting motifs.
The Journal of biological chemistry
Hecker CM, Rabiller M, Haglund K, Bayer P, Dikic I PubMed
Jun 2006 Volume: 281 Issue: 23 Pages: 16117-27

Regulation of ubiquitin-binding proteins by monoubiquitination.
Nature cell biology
Hoeller D, Crosetto N, Blagoev B, Raiborg C, Tikkanen R, Wagner S, Kowanetz K, Breitling R, Mann M, Stenmark H, Dikic I PubMed
Feb 2006 Volume: 8 Issue: 2 Pages: 163-9

A clinoptilolite effect on cell media and the consequent effects on tumor cells in vitro.
Frontiers in bioscience : a journal and virtual library
Katic M, Bosnjak B, Gall-Troselj K, Dikic I, Pavelic K PubMed
May 2006 Volume: 11 Issue: Pages: 1722-32

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Science (New York, N.Y.)
Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, Kannouche P, Wider G, Peter M, Lehmann AR, Hofmann K, Dikic I PubMed
Dec 2005 Volume: 310 Issue: 5755 Pages: 1821-4

CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway.
Biochemical and biophysical research communications
Aissouni Y, Zapart G, Iovanna JL, Dikic I, Soubeyran P PubMed
Dec 2005 Volume: 338 Issue: 2 Pages: 808-14

Cbl promotes clustering of endocytic adaptor proteins.
Nature structural & molecular biology
Jozic D, Cárdenes N, Deribe YL, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J PubMed
Nov 2005 Volume: 12 Issue: 11 Pages: 972-9

The Cbl interactome and its functions.
Nature reviews. Molecular cell biology
Schmidt MH, Dikic I PubMed
Dec 2005 Volume: 6 Issue: 12 Pages: 907-18

CIN85 regulates the ligand-dependent endocytosis of the IgE receptor: a new molecular mechanism to dampen mast cell function.
Journal of immunology (Baltimore, Md. : 1950)
Molfetta R, Belleudi F, Peruzzi G, Morrone S, Leone L, Dikic I, Piccoli M, Frati L, Torrisi MR, Santoni A, Paolini R PubMed
Oct 2005 Volume: 175 Issue: 7 Pages: 4208-16

Ubiquitylation and cell signaling.
The EMBO journal
Haglund K, Dikic I PubMed
Oct 2005 Volume: 24 Issue: 19 Pages: 3353-9

Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells.
The Journal of biological chemistry
Eckerdt F, Yuan J, Saxena K, Martin B, Kappel S, Lindenau C, Kramer A, Naumann S, Daum S, Fischer G, Dikic I, Kaufmann M, Strebhardt K PubMed
Nov 2005 Volume: 280 Issue: 44 Pages: 36575-83

Deregulation of cell growth and malignant transformation.
Croatian medical journal
Sulić S, Panić L, Dikić I, Volarević S PubMed
Aug 2005 Volume: 46 Issue: 4 Pages: 622-38

Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.
EMBO reports
Haglund K, Schmidt MH, Wong ES, Guy GR, Dikic I PubMed
Jul 2005 Volume: 6 Issue: 7 Pages: 635-41

Oncogenic breakdowns in endocytic adaptor proteins.
FEBS letters
Crosetto N, Tikkanen R, Dikic I PubMed
Jun 2005 Volume: 579 Issue: 15 Pages: 3231-8

Compartmentalization of growth factor receptor signalling.
Current opinion in cell biology
Hoeller D, Volarevic S, Dikic I PubMed
Apr 2005 Volume: 17 Issue: 2 Pages: 107-11

Molecular responses to acidosis of central chemosensitive neurons in brain.
Cellular signalling
Shimokawa N, Dikic I, Sugama S, Koibuchi N PubMed
Jul 2005 Volume: 17 Issue: 7 Pages: 799-808

Implication of phospholipase D2 in oxidant-induced phosphoinositide 3-kinase signaling via Pyk2 activation in PC12 cells.
The Journal of biological chemistry
Banno Y, Ohguchi K, Matsumoto N, Koda M, Ueda M, Hara A, Dikic I, Nozawa Y PubMed
Apr 2005 Volume: 280 Issue: 16 Pages: 16319-24

Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities.
The Journal of biological chemistry
Schmidt MH, Dikic I, Bögler O PubMed
Feb 2005 Volume: 280 Issue: 5 Pages: 3414-25

Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex.
Molecular and cellular biology
Schmidt MH, Hoeller D, Yu J, Furnari FB, Cavenee WK, Dikic I, Bögler O PubMed
Oct 2004 Volume: 24 Issue: 20 Pages: 8981-93

Cargo- and compartment-selective endocytic scaffold proteins.
The Biochemical journal
Szymkiewicz I, Shupliakov O, Dikic I PubMed
Oct 2004 Volume: 383 Issue: Pt 1 Pages: 1-11

ALIX-ing phospholipids with endosome biogenesis.
BioEssays : news and reviews in molecular, cellular and developmental biology
Dikic I PubMed
Jun 2004 Volume: 26 Issue: 6 Pages: 604-7

Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.
The Journal of biological chemistry
Kowanetz K, Crosetto N, Haglund K, Schmidt MH, Heldin CH, Dikic I PubMed
Jul 2004 Volume: 279 Issue: 31 Pages: 32786-95

SH3P2 in complex with Cbl and Src.
FEBS letters
Szymkiewicz I, Destaing O, Jurdic P, Dikic I PubMed
May 2004 Volume: 565 Issue: 1-3 Pages: 33-8

Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites.
Journal of cell science
Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I PubMed
May 2004 Volume: 117 Issue: Pt 12 Pages: 2557-68

Phosphorylation of JNK is involved in regulation of H(+)-induced c-Jun expression.
Cellular signalling
Shimokawa N, Qiu CH, Seki T, Dikic I, Koibuchi N PubMed
Jun 2004 Volume: 16 Issue: 6 Pages: 723-9

CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors.
Molecular biology of the cell
Kowanetz K, Husnjak K, Höller D, Kowanetz M, Soubeyran P, Hirsch D, Schmidt MH, Pavelic K, De Camilli P, Randazzo PA, Dikic I PubMed
Jul 2004 Volume: 15 Issue: 7 Pages: 3155-66

Receptor endocytosis via ubiquitin-dependent and -independent pathways.
Biochemical pharmacology
Höller D, Dikic I PubMed
Mar 2004 Volume: 67 Issue: 6 Pages: 1013-7

Distinct monoubiquitin signals in receptor endocytosis.
Trends in biochemical sciences
Haglund K, Di Fiore PP, Dikic I PubMed
Nov 2003 Volume: 28 Issue: 11 Pages: 598-603

Dab2 links CIN85 with clathrin-mediated receptor internalization.
FEBS letters
Kowanetz K, Terzic J, Dikic I PubMed
Nov 2003 Volume: 554 Issue: 1-2 Pages: 81-7

Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.
The Journal of biological chemistry
Kowanetz K, Szymkiewicz I, Haglund K, Kowanetz M, Husnjak K, Taylor JD, Soubeyran P, Engstrom U, Ladbury JE, Dikic I PubMed
Oct 2003 Volume: 278 Issue: 41 Pages: 39735-46

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation.
Nature cell biology
Haglund K, Sigismund S, Polo S, Szymkiewicz I, Di Fiore PP, Dikic I PubMed
May 2003 Volume: 5 Issue: 5 Pages: 461-6

Negative receptor signalling.
Current opinion in cell biology
Dikic I, Giordano S PubMed
Apr 2003 Volume: 15 Issue: 2 Pages: 128-35

Protein kinase A mediates cAMP-induced tyrosine phosphorylation of the epidermal growth factor receptor.
Biochemical and biophysical research communications
Piiper A, Lutz MP, Cramer H, Elez R, Kronenberger B, Dikic I, Müller-Esterl W, Zeuzem S PubMed
Feb 2003 Volume: 301 Issue: 4 Pages: 848-54

Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
The Biochemical journal
Soubeyran P, Barac A, Szymkiewicz I, Dikic I PubMed
Feb 2003 Volume: 370 Issue: Pt 1 Pages: 29-34

Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shimokawa N, Okada J, Haglund K, Dikic I, Koibuchi N, Miura M PubMed
Nov 2002 Volume: 22 Issue: 21 Pages: 9160-5

CIN85/CMS family of adaptor molecules.
FEBS letters
Dikic I PubMed
Oct 2002 Volume: 529 Issue: 1 Pages: 110-5

Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.
Proceedings of the National Academy of Sciences of the United States of America
Haglund K, Shimokawa N, Szymkiewicz I, Dikic I PubMed
Sep 2002 Volume: 99 Issue: 19 Pages: 12191-6

Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells.
The Journal of biological chemistry
Piiper A, Dikic I, Lutz MP, Leser J, Kronenberger B, Elez R, Cramer H, Müller-Esterl W, Zeuzem S PubMed
Nov 2002 Volume: 277 Issue: 46 Pages: 43623-30

CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.
The Journal of biological chemistry
Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I PubMed
Oct 2002 Volume: 277 Issue: 42 Pages: 39666-72

Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.
Nature
Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I PubMed
Mar 2002 Volume: 416 Issue: 6877 Pages: 183-7

Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D.
The Biochemical journal
Sajan MP, Bandyopadhyay G, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV PubMed
Mar 2002 Volume: 362 Issue: Pt 3 Pages: 665-74

Proline-rich tyrosine kinase 2 regulates proliferation and differentiation of prostate cells.
Molecular and cellular endocrinology
Picascia A, Stanzione R, Chieffi P, Kisslinger A, Dikic I, Tramontano D PubMed
Jan 2002 Volume: 186 Issue: 1 Pages: 81-7